inotropic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5033	Olprinone	Loprinone	PDE
	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...		PDE
T1265	Amrinone	Inamrinone,Inocor,Wincoram	TNF , PDE
	Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.		TNF , PDE
T15050	Danicamtiv	MYK-491,SAR 440181	Myosin
	Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.		Myosin
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T1320	Disopyramide	Triombrin,Hypaque sodium,amidotrizoate sodium	Potassium Channel , Sodium Channel , AChR
	Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the h...		Potassium Channel , Sodium Channel , AChR
T33806	Opc 18750	Opc18750,Opc-18750	Others
	Opc 18750 is a compound with selective and positive inotropic effects.		Others
T33589	Nanterinone	UK-61260,UK61260,UK 61260	PDE
	Nanterinone (UK 61260), an orally available partial phosphodiesterase inhibitor, is a novel positive inotropic and balanced vasodilator compound.Nanterinone, when administered orally, results in significant improvements ...		PDE
T21457	Carbazeran	UK-31557,UK31,557,UK-31,557,UK31557,UK 31557,UK 31,557	PDE
	Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases. Carbazeran shows inotropic and chronotropic effects in vivo(EC50 = 100 μM).		PDE
T71744	Imazodan		PDE
	Imazodan, a small molecule compound with positive inotropic activity, is a selective type III phosphodiesterase inhibitor and can be used to study heart failure.		PDE
T83974	OPC18750 HCl		PDE
	OPC18750 HCl is a potential phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.		PDE
T14507	Bay 60-7550	BAY 607550	PDE
	Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem...		PDE
TP2044L	α-CGRP (human) acetate	α-CGRP (human) acetate (90954-53-3 free base)	Others
	α-CGRP (human) acetate is a regulatory neuropeptide of 37 amino acids. It is the most potent vasodilator known to date and has inotropic and chronotropic effects.		Others
T8149	Dobutamine hydrochloride	Dobutamine (hydrochloride)	Adrenergic Receptor
	Dobutamine hydrochloride (Dobutamine (hydrochloride)) is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects.		Adrenergic Receptor
T3920	Pseudoginsenoside F11	Ginsenoside A1	Others , Endogenous Metabolite
	Pseudoginsenoside F11 (Ginsenoside A1) is a component of Panax quinquefolium (American ginseng) which main pharmacological activities are positive inotropic effect on isolated heart function, good therapeutic effect on m...		Others , Endogenous Metabolite
T27205	DPI 201-106	DPI-201-106	Sodium Channel
	DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents.		Sodium Channel
T2939	Forskolin	Coleonol,Colforsin	FXR , Adenylyl cyclase , AChR , Autophagy
	Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...		FXR , Adenylyl cyclase , AChR , Autophagy
T3465L	Vesnarinone HCl	Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel , Calcium Channel , PDE
	Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new...		Potassium Channel , Calcium Channel , PDE
T3S0629	Delsoline	Belsoline	Others
	1. Delsoline (Belsoline) has hypotensive effects.2. Delsoline is not only effective in preventing ventricular fibrillation and arrythmia, but can raise the intebsity of the threthold of electrical shocks to cause ventric...		Others
T0871	Noradrenaline bitartrate		Adrenergic Receptor
	Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the ...		Adrenergic Receptor
T32829	Lnd 623	Lnd-623,Lnd623
	Lnd 623 is an inotropic aminosteroid.