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Search Results for " hemolysis "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T76702	Sutimlimab		Complement System
	Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemolysis.		Complement System
T39520	Vamifeport	VIT-2763	Ferroptosis
	Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inf...		Ferroptosis
T76831	Tesidolumab	LFG316	Complement System
	Tesidolumab (LFG316) is a fully human IgG1/λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cutting of C5 and preventing the subsequent formation of membrane...		Complement System
T36766	Palmitoylcholine (chloride)
	Palmitoylcholine is an acyl choline.1It inhibits protein kinase C activity when used at a concentration of 100 μM.2Palmitoylcholine induces hemolysis in rat erythrocytes.3Plasma levels of palmitoylcholine are decreased i...
T62020	Pelecopan
	Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D (IC50= 14.3 nM). Pelecopan can prevent both intravascular and extravascular hemolysis in PNH.
T83748	RW4 TFA	(RW)4-NH2,Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2
	RW4, an antimicrobial peptide, exhibits activity against E. coli and S. aureus, with IC50 values of 9.6 and 5.1 µM, respectively. Additionally, it induces hemolysis of isolated ovine erythrocytes.
T83747	RW3 TFA	(RW)3-NH2,Arg-Trp-Arg-Trp-Arg-Trp-NH2
	RW3, an antimicrobial peptide, exhibits activity against E. coli and S. aureus with IC50 values of 16 µM and 8 µM, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.
T83746	RW2 TFA	(RW)2-NH2,Arg-Trp-Arg-Trp-NH2
	RW2, an antimicrobial peptide, demonstrates activity against E. coli and S. aureus, with IC50 values of 730 µM and 210 µM, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.
T69589	PX-316
	PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor act...
T77121	Pozelimab
	Pozelimab (REGN3918), a fully human IgG4 monoclonal antibody, is designed to target and bind with high affinity to both C5 and its variants, effectively inhibiting complement-mediated hemolysis. It holds potential for re...
T36784	Filipin II
	Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H...
T83698	Cathelicidin-2 (128-153) (chicken) TFA	Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153)
	Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globi...
T83738	SMAP 29 (ovine) TFA	Sheep Myeloid Antimicrobial Peptide 29
	SMAP 29, a bactericidal antimicrobial peptide and a cleavage product from the C-terminus of an ovine cathelicidin prepropeptide, is effective against P. aeruginosa strain PAO1 in both low- and high-salt conditions, as de...
T83750	Melittin (C-Term Cysteine labeled) TFA	Mel-Cys
	Melittin (C-term cysteine labeled), a variant of the toxic bee venom peptide melittin featuring a cysteine residue at its C-terminus, effectively induces hemolysis in isolated human red blood cells at both endosomal and ...
T83853	L-K6L9 TFA
	L-K6L9, a cytolytic peptide comprised of L-isomer leucine and lysine, demonstrates cytotoxicity against both androgen-independent (LNCaP-CL1) and androgen-dependent (22Rv1 and LNCaP) human prostate cancer cells, with LC5...
T83706	BMAP 28 (bovine) TFA	Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28
	Bovine Myeloid Antimicrobial Peptide (BMAP) 28, a synthetic peptide derived from bovine cathelicidin-5 (amino acids 132-158), exhibits antimicrobial activity against E. coli, S. aureus, MRSA, S. epidermidis, and the fung...

Compounds

Sutimlimab

T76702

Synonym:

Target: Complement System

Target: Complement System

Palmitoylcholine (chloride)

Synonym: (RW)4-NH2,Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2

Target:

RW3 TFA

T83747

Synonym: (RW)3-NH2,Arg-Trp-Arg-Trp-Arg-Trp-NH2

Target:

RW2 TFA

T83746

Synonym: (RW)2-NH2,Arg-Trp-Arg-Trp-NH2

Cathelicidin-2 (128-153) (chicken) TFA

T83698

Synonym: Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153)

Target:

SMAP 29 (ovine) TFA

T83738

Synonym: Sheep Myeloid Antimicrobial Peptide 29

Target:

Melittin (C-Term Cysteine labeled) TFA

Synonym: Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28

Target:

Cat No.	Product Name	Synonyms	Targets
TN1438	Beta-Amyrin acetate		Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal
	beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
TN6909	Polyporusterone B	(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one	Others
	Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci...		Others
TN1256	3-O-Acetyl-16α-hydroxytrametenolic acid	3-O-Acetyl-16 alpha-hydroxytrametenolic acid	Immunology/Inflammation related
	3-O-Acetyl-16α-hydroxytrametenolic acid has inhibitory activities against AAPH-induced hemolysis of red blood cells, it shows a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation...		Immunology/Inflammation related
TN1125	Neonuezhenide		Antioxidant
	Neonuezhenide is a phenolic compound isolated from Ligustrum officinale, which has strong antioxidant effects on free radical-induced hemolysis of red blood cells.		Antioxidant
TN6908	Polyporusterone A	(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one
	Polyporusterone A is a triterpene carboxylic acid derived from the substrates of P. umbellatus.Polyporusterone A inhibits free radical-induced erythrocyte cleavage (hemolysis), and can be used in studies of hair regenera...
TN1369	Alloimperatorin	Prangenidin	Others
	Alloimperatorin (Prangenidin) exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration. It photosensitizes efficient...		Others
TN1742	Homovanillyl alcohol		TNF , Drug Metabolite
	Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homovanillyl alcohol displays high scavenging activities, it pr...		TNF , Drug Metabolite
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T70891	Pyridoxatin
	Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans.
TN1728	Hellebrigenin		PARP , Akt , CDK
	Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against ...		PARP , Akt , CDK
T82682	Convicine
	Convicine, a pyrimidine glycoside found in faba beans [1] [2], serves as the precursor for the aglycones Divicine and Isouramil, alongside Vicine. It is a principal factor in favism, a genetic disorder that causes severe...

Natural Products

beta-Amyrin acetate

TN1438

Synonym:

Target: Antioxidant, HMG-CoA Reductase, Epoxide Hydrolase, Antifungal

Polyporusterone B

TN6909

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Target: Others

3-O-Acetyl-16α-hydroxytrametenolic acid

TN1256

Synonym: 3-O-Acetyl-16 alpha-hydroxytrametenolic acid

Target: Immunology/Inflammation related

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Target: TNF, Drug Metabolite

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Target: PARP, Akt, CDK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-03562	Leukocidin-F subunit/LukF Protein, S. aureus, Recombinant (His & Myc & SUMO)	Staphylococcus aureus	E. coli
	Leukocidin causes cytotoxic changes in polymorphonuclear leukocytes. Gamma-hemolysin causes hemolysis in red blood cells.
TMPH-00026	Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His)	Actinia equina	E. coli
	Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphin...
TMPH-02701	Haptoglobin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to preven...
TMPH-00511	Lysenin Protein, Eisenia fetida, Recombinant (His)	Eisenia fetida	E. coli
	Pore-forming toxin that defensively acts against parasitic microorganisms by forming pores in sphingomyelin-containing membranes. Has hemolytic activity and is also cytotoxic to spermatozoa of some species of invertebrat...
TMPJ-00817	HO-1 Protein, Human, Recombinant	Human	E. coli
	Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to ...
TMPJ-00836	G6PD Protein, Human, Recombinant (His)	Human	Human Cells
	Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by ...
TMPH-00534	Gelatinase Protein, Enterococcus faecalis, Recombinant (His & SUMO)	Enterococcus faecalis	E. coli
	Metalloprotease capable of the hydrolysis of insoluble hydrophobic substrates. Hydrolyzes azocoll and gelatin and, at a lower rate, soluble and insoluble collagens. Does not cleave short synthetic peptides. Preferentiall...
TMPJ-00730	Haptoglobin Protein, Human, Recombinant (C-His)	Human	Human Cells
	Haptoglobin(HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin ...
TMPJ-00729	Haptoglobin Protein, Human, Recombinant (N-His)	Human	E. coli
	Haptoglobin(HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin ...