halogenated

P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.

Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.

Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.

Halothane (Anestan) is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required.

Enflurane (Efrane), a volatile anaesthetic, is a potent inhibitor of high conductance Ca2+-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry. It allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.

4'-Bromomethyl-2-cyanobiphenyl is a halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

Rafoxanide as a dual CDK4 6 inhibitor for the treatment of skin cancer. Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations.

Chiniofon (Ferron), a halogenated 8-hydroxyquinoline, is used as an antiamebic drug. This type of anti-amebic drug exerts an anti-amebic effect by inhibiting intestinal commensal bacteria and affects amoebic dysentery, but has no effect on extra-intestinal amoebic parasites.

Methylprednisolone Aceponate (SH 440), a non-halogenated corticosteroid, is a potent anti-inflammatory agent.

HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity

Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.Ropidoxuridine is an orally available and bioavailable IUdR (5-iodo-2'-deoxyuridine) prodrug.

4-Bromo A23187, a halogenated analog of the calcium ionophore A-23187, acts as a calcium modulator and induces apoptosis in various cells.

Hydrocortisone buteprate (Hydrocortisone probutate) is a medium-potent, non-halogenated double-ester of hydrocortisone, with a favorable benefit risk ratio for treating inflammatory skin disorders.

RM-5038 is a halogenated thiazole compound with multiple pharmacological properties, capable of combating a broad range of parasites, bacteria, and viruses through at least three mechanisms of action. Specifically, in respiratory viruses, RM-5038 can inhibit the replication of Paramyxoviridae and Pneumoviridae at the post-translational level.

Broquinaldol is a halogenated derivative based on quinoline and is also categorized as a halogenated phenazine compound.

4-Iodoamphetamine (p-Iodoamphetamine) hydrochloride is a halogenated phenethylamine characterized by the presence of an iodine atom at the para position of the phenyl group. It selectively induces serotonin release and inhibits reuptake in rat brain synaptosomes.

Johnstonol is an specifically halogenated epoxide obtained from the red alga.

CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer. |1. Kadayat, T.M., Park, S., Shrestha, A., et al. Discovery and biological evaluations of halogenated 2,4-diphenyl indeno[1,2-b]pyridinol derivatives as potent topoisomerase IIa-targeted chemotherapeutic agents for breast cancer. J. Med. Chem. 62, 8194-8234 (2019).

1,1-Dibromo-3-chloroacetone is a halogenated disinfection byproduct (DBP) formed under high bromide levels when chlorine or chloramine is used as a secondary disinfectant in ozone-chlorine and ozone-chloramine processes.

1,1,1,3-Tetrachloroacetone, a halogenated compound, is known to form ozone-chlorine and ozone-chloramine disinfection byproducts (DBPs) when elevated bromide levels are present in water treated with chlorine or chloramine as secondary disinfectants.

Dibromoacetaldehyde, a halogenated byproduct found in drinking water, exhibits genotoxicity.

1,1,3-Tribromo-3-chloroacetone is a chemical compound that acts as a halogenated disinfection byproduct (DBP) formed in the presence of elevated bromide levels during chlorine or chloramine use as a secondary disinfectant, attributed to reactions between ozone-chlorine and ozone-chloramine.

1,3-Dibromo-1,3-dichloroacetone is a chemical compound that forms as a disinfection byproduct (DBP) from the use of halogenated ozone-chlorine and ozone-chloramine, especially at elevated bromide concentrations, when used as secondary disinfectants.