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Results for "

growth-regulated a protein

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    6
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    1
    TargetMol | Compound_Libraries
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    1
    TargetMol | PROTAC
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    TargetMol | Natural_Products
  • Recombinant Protein
    31
    TargetMol | Recombinant_Protein
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CXCL1 Protein, Mouse, Recombinant (His)
Secretory protein N51, Scyb1, Platelet-derived growth factor-inducible protein KC, Mgsa, Growth-regulated α, Growth-regulated alpha protein, Gro1, Gro, Cxcl1, C-X-C motif chemokine 1
TMPJ-00006
Growth-regulated alpha protein (CXCL1,KC), is a member of the alpha chemokine subfamily, was initially identified as an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor. The N-terminal processed form KC(5-72) of the protein is produced by proteolytic cleavage after secretion from bone marrow stromal cells, and shows a highly enhanced hematopoietic activity. Mouse KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60% identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the orthologs of the human GROs and rat CINCs. Cxcl1 has chemotactic activity for neutrophils, and contributes to neutrophil activation during inflammation. Hematoregulatory chemokine, in vitro, suppresses hematopoietic progenitor cell proliferation.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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CXCL1 Protein, Mouse, Recombinant (Active)
Secretory protein N51, Scyb1, Platelet-derived growth factor-inducible protein KC, Mgsa, Growth-regulated alpha protein, Gro1, Gro, Cxcl1, C-X-C motif chemokine 1
TMPH-04280
Expression system: E. coli
Length: 25-96, Full Length of Mature Protein
Activity: Cell Activity
  • Inquiry Price
20 days
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QTY
Buffer-exchangeable
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SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD3, SMAD family member 3, SMAD 3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, MADH3, Mad3, MAD homolog 3, JV15-2, hSMAD3, hMAD-3
TMPJ-00271
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3 SMAD4 complex, activates transcription. It also can form a SMAD3 SMAD4 JUN FOS complex at the AP-1 SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.
  • Inquiry Price
7-10 days
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GAS6 Protein, Human, Recombinant (hFc)
growth arrest-specific protein 6, growth arrest-specific 6, GAS-6, Gas6, AXSFAXL receptor tyrosine kinase ligand, AXLLGAXL stimulatory factor, AXLLG
TMPJ-00366
Expression system: HEK293 Cells
Length: 31-678, Full Length of Mature Protein
Activity: BLI、ELISA
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer
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CD117 Protein, Human, Recombinant (hFc)
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Tyrosine-protein kinase Kit, SCFR, Proto-oncogene c-Kit, Piebald trait protein, PBT, p145 c-kit, Mast stem cell growth factor receptor Kit, KIT, CD117
TMPJ-00402
C-Kit SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1 PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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Vasorin Protein, Human, Recombinant (His)
Vasorin, VASN, SLITL2, Protein Slit-Like 2
TMPJ-00572
Vasorin is a Type I membrane protein, which is predominantly expressed in vascular smooth muscle cells in a developmentally regulated pattern. The expression level of Vasorin can be down regulated during vessel repair after arterial injury. Vasorin binds to transforming growth factor beta (TGF-β) and attenuates TGF-β signaling in vitro.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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FGF-4 Protein, Mouse, Recombinant
Transforming protein KS3, KS3, HSTF-1, HSTF1, HST-1, HST, Heparin-binding growth factor 4, Heparin secretory-transforming protein 1, HBGF-4, Fibroblast growth factor 4, FGF-4, FGF4
TMPJ-00835
Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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BMP-5 Protein, Human, Recombinant (hFc)
bone morphogenetic protein 5
TMPY-00681
Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily. In agreement with a possible role in the control of cell death, BMP-5 exhibited a regulated pattern of expression in the interdigital tissue. Transcripts of BMP-5 and BMP-5 protein were abundant within the cytoplasm of the fragmenting apoptotic interdigital cells in a way suggesting that delivery of BMPs into the tissue is potentiated during apoptosis. Gain-of-function experiments demonstrated that BMP-5 has the same effect as other interdigital BMPs inducing apoptosis in the undifferentiated mesoderm and growth in the prechondrogenic mesenchyme. BMP-5 is a member of the 60A subgroup of BMPs, other members of which have been shown to stimulate dendritic growth in central and peripheral neurons. The signaling pathway that mediates the dendrite-promoting activity of BMP-5 may involve binding to BMPR-IA and activation of Smad-1, and relative levels of BMP antagonists such as noggin and follistatin may modulate BMP-5 signaling. Since BMP-5 is expressed at relatively high levels not only in the developing but also the adult nervous system, these findings suggest the possibility that BMP-5 regulates dendritic morphology not only in the developing but also the adult nervous system. BMP-5 may play important roles not only in myocardial differentiation but also in the formation and maintenance of endocardial cushion tissue. Additionally, a high expression level of BMP-5 has been detected in certain tumors of mesenchymal origin.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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COMP Protein, Human, Recombinant (His)
THBS5, PSACH, MED, EPD1, EDM1, cartilage oligomeric matrix protein
TMPY-00725
Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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WISP1/CCN4 Protein, Human, Recombinant (His)
WNT1 inducible signaling pathway protein 1, WISP1tc, WISP1i, WISP1c, CCN4
TMPY-00950
CCN4 Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF CYR61 NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a von Willebrand type C domain, a thrombospondin domain and a C-terminal cysteine -knot domain. WISP1 is a putative downstream effector of the Wnt Frizzled pathway that mediates diverse developmental processes, was identified as an oncogene regulated by the Wnt-1-beta-catenin pathway. Thus WISP1 may contribute to Wnt-1-mediated tumorigenesis and malignance. Expression of WISP1 in some cells results in transformation and tumorigenesis. WISP1 acts to block cell death at a late stage in the p53-mediated apoptosis pathway. It was reported that WISP1 interacts with sulfated glycoconjugates, decorin and biglycan in the ECM of connective tissue, and possibly prevents their inhibitory activity in tumor cell proliferation.
  • Inquiry Price
7-10 days
Size
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SPR-compatible buffer
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CASPR2 Protein, Mouse, Recombinant (His)
mKIAA0868, contactin associated protein-like 2, Caspr2, 5430425M22Rik
TMPY-01695
CNTNAP2 CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5 8 type C domain, discoidin neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2 CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2 CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2 CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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Acetylcholinesterase Protein, Mouse, Recombinant (His)
Chrne, Acre, acetylcholinesterase (Yt blood group)
TMPY-01742
Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. ACHE was significantly down-regulated in the cancerous tissues of 69.2% of hepatocellular carcinoma (HCC) patients, and the low ACHE expression in HCC was correlated with tumor aggressiveness, an elevated risk of postoperative recurrence, and a low survival rate. Both the recombinant ACHE protein and the enhanced expression of ACHE significantly inhibited HCC cell growth in vitro and tumorigenicity in vivo. ACHE as a tumor growth suppressor in regulating cell proliferation, the relevant signaling pathways, and the drug sensitivity of HCC cells. Thus, ACHE is a promising independent prognostic predictor for HCC recurrence and the survival of HCC patients. ACHE is responsible for the hydrolysis of acetylcholine in the nervous system. It is inhibited by organophosphate and carbamate pesticides. However, this enzyme is only slightly inhibited by organophosphorothionates.
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7-10 days
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SPR-compatible buffer
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CLIC4 Protein, Human, Recombinant (His)
p64H1, MTCLIC, huH1, H1, CLIC4L, chloride intracellular channel 4
TMPY-01890
Expression system: E. coli
Length: 2-253, Full Length of Mature Protein
Activity: Not Tested
  • Inquiry Price
7-10 days
Size
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SPR-compatible buffer
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BLVRB Protein, Human, Recombinant (His)
SDR43U1, HEL-S-10, FLR, BVRB, biliverdin reductase B
TMPY-02519
Biliverdin reductase (hBVR) is a serine threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step in heme degradation by reducing the γ-methene bridge of the open tetrapyrrole, biliverdin IXα, to bilirubin with the concomitant oxidation of a β-nicotinamide adenine dinucleotide (NADH) or β-nicotinamide adenine dinucleotide phosphate (NADPH) cofactor. It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser Thr and Tyr) upstream activator of the insulin insulin growth factor-1 (IGF-1) and mitogen-activated protein kinase (MAPK) signaling pathways. Human BVR (hBVR) is essential for MAPK-extracellular signal-regulated kinase (ERK)1 2 (MEK)-eukaryotic-like protein kinase (Elk) signaling and has been identified as the cytoplasm-nuclear heme transporter of ERK1 2 and hematin, the key components of stress-responsive gene expression.
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7-10 days
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NRN1 Protein, Human, Recombinant (His)
NRN, neuritin 1, MGC44811, dJ380B8.2
TMPY-02579
Expression system: Baculovirus Insect Cells
Length: 1-115, Partial
Activity: Not Tested
  • Inquiry Price
7-10 days
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DEP-1 Protein, Human, Recombinant (aa 997-1337, His)
SCC1, R-PTP-ETA, protein tyrosine phosphatase, receptor type, J, HPTPeta, DEP1, CD148
TMPY-02763
DEP1 PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.
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7-10 days
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SPR-compatible buffer
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IDO2 Protein, Human, Recombinant (His)
indoleamine 2,3-dioxygenase 2, INDOL1
TMPY-02803
Expression system: E. coli
Length: 14-420, Full Length
Activity: Not Tested
  • Inquiry Price
7-10 days
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EBP1 Protein, Human, Recombinant (His)
proliferation-associated 2G4, p38-2G4, HG4-1, EBP1
TMPY-02844
Expression system: E. coli
Length: 2-394, Full Length of Mature Protein
Activity: Not Tested
  • Inquiry Price
7-10 days
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QTY
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SLITL2/VASN Protein, Human, Recombinant (His)
vasorin, SLITL2
TMPY-03058
Expression system: HEK293 Cells
Length: 1-575, Partial
Activity: Not Tested
  • Inquiry Price
7-10 days
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QTY
SPR-compatible buffer
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GADD45G Protein, Human, Recombinant
GRP17, growth arrest and DNA-damage-inducible, γ, growth arrest and DNA-damage-inducible, gamma, GADD45γ, GADD45gamma, DDIT2, CR6
TMPY-03655
Expression system: E. coli
Length: 1-159, Full Length
Activity: Not Tested
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer
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DCBLD2 Protein, Human, Recombinant (His)
ESDN, discoidin, CUB and LCCL domain containing 2, CLCP1
TMPY-03853
Expression system: HEK293 Cells
Length: 1-482, Partial
Activity: Not Tested
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer