csc

Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.

Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi. Cyclosporin C has antifungal, antiviral, and immunosuppressant properties.

CSC-6 is an inhibitor of NLRP3. It significantly reduces the secretion of IL-1β in PMATHP-1 cells, with an IC50 of 2.3 μM. CSC-6 specifically binds to NLRP3 and prevents its activation by obstructing ASC oligomerization during the NLRP3 assembly process. It effectively alleviates symptoms of sepsis and gout mediated by excessive NLRP3 activation in mouse models.

EGFR/CSC-IN-1 is a dual inhibitor of the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), potentially applicable in triple-negative breast cancer research.

8-CSC is a dual agent endowed with good hMAO-B inhibitory activity (Ki: 235 nM in baboon liver mitochondria) and A2A affinity (Ki: 36 nM in rat brain striatal membranes receptor).

Compound CSC000682698 is a high-purity biochemical reagent with CAS number 123530-67-6, suitable for biochemical experiments and drug synthesis research.

Compound CSC000750700 is a high-purity biochemical reagent with CAS number 23457-00-5, suitable for biochemical experiments and drug synthesis research.

Compound CSC000017688 is a high-purity biochemical reagent with CAS number 6497-88-7, suitable for biochemical experiments and drug synthesis research.

Compound CSC000754622 is a high-purity biochemical reagent with CAS number 102880-53-5, suitable for biochemical experiments and drug synthesis research.

Compound CSC000681006 is a high-purity biochemical reagent with CAS number 89152-61-4, suitable for biochemical experiments and drug synthesis research.

GBM CSCs-IN-1 (Compound (−)-20), a rocaglate derivative, potently inhibits glioblastoma stem cells (GBM CSCs) and exhibits an EC50 of 45 nM by targeting the RNA helicase DDX3. Additionally, it induces apoptosis in these cells.

AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.

Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.

cRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors.

Antibiotic Sch 378167 is a useful organic compound for research related to life sciences. The catalog number is T125021 and the CAS number is 336108-99-7.

Antibiotic Sch 60057 is a useful organic compound for research related to life sciences. The catalog number is T125403 and the CAS number is 203061-35-2.

Antibiotic Sch 60061 is a useful organic compound for research related to life sciences. The catalog number is T125404 and the CAS number is 203061-33-0.

Antibiotic Sch 60065 is a useful organic compound for research related to life sciences. The catalog number is T125405 and the CAS number is 203061-31-8.

Antibiotic Sch 60059 is a useful organic compound for research related to life sciences. The catalog number is T125406 and the CAS number is 203061-30-7.

Echinomycin (Quinomycin A) is an antitumor antibiotic secondary metabolite isolated from Streptomyces, a quinoxaline antibiotic, a DNA doubly intercalating peptide, and inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity. Echinomycin has potential anticancer activity and can be used to study triple-negative breast cancer.

Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).

9C-SCC-10 is a crown-shaped biodegradable ionizable lipid. It is used in the preparation of lipid nanoparticles for delivering mRNA and targeting lung tissue. Additionally, 9C-SCC-10 can be employed in the early detection and diagnosis of lung cancer.

Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.