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Search Result

Search Results for " cirrhosis "

Targets

Others

19

Compounds

6

Natural Products

18

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T19399 L-Ornithine L-aspartate Ornithine Aspartate Others
L-Ornithine L-aspartate (Ornithine Aspartate) lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis.
T1410 Torsemide AC-4464,JDL-464,Torasemide Na-K-Cl cotransporter
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...
T3611 Sodium Glucuronic Acid Sodium Glucoronic,4-FLUOROCINNAMONITRILE Others
Sodium Glucuronic Acid (4-FLUOROCINNAMONITRILE) is used in the treatment of hepatitis and liver cirrhosis.
T6576 Malotilate Malotilatum,NKK 105,Kantec Lipoxygenase
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.
T60226 CT52923 PDGFR
CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatile applications for researching an array of pathological dis...
T6993 Tauroursodeoxycholate sodium Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,Sodium Tauroursodeoxycholate (TUDC) Apoptosis , ERK , Caspase
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
T63751 Selvigaltin GB1211 Neuropeptide Y Receptor
Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.
T73446 BI‑3231 Dehydrogenase
BI‑3231 is a selective and potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis...
T62882 Ezurpimtrostat hydrochloride
Ezurpimtrostat hydrochloride (compound 2-3) is an orally active antifibrotic agent that significantly reduces liver fibrosis in rats with DEN (diethylnitrosamine) cirrhosis. CTSB, CTSL and CTSD related diseases.
T76700 Simtuzumab GS 6624,AB 0024 Monoamine Oxidase
Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato...
T28664 Satavaptan SR121463,SR 121463,SR-121463
Satavaptan is a vasopressin V2 receptor antagonist. Satavaptan improves the control of ascites in cirrhosis.
T34107 Polythiazide P2525,NSC-108161,NSC 108161,P-2525,NSC108161
Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medic...
T34773 TAK-044 TAK044
TAK-044 is an endotheliin receptor antagonist that prevents and reverses the development of carbon tetrachloride induced cirrhosis in rats. TAK-044 showed a protective effect on neuronal activity in vitro hypoxic glucose...
T80270 Invopressin OCE-205 Vasopressin Receptor
Invopressin (Compound 42), a vasopressin V1A receptor partial agonist (EC50: 1.0 nM), is utilized in research related to cirrhosis conditions such as bacterial peritonitis, HRS2, and refractory ascites [1].
T69133 Etozolin HCl
Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vasc...
T37846 Taurohyocholic Acid (sodium salt)
Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline ...
T16376 Odevixibat A4250 Others
Odevixibat (A4250) is an effective, selective and orally active ileal bile acid transporter inhibitor. Odevixibat has the potential for the treatment of primary biliary cirrhosis. Odevixibat reduces cholestatic liver and...
T73155 BMS-986339
BMS-986339 is an orally active, potent FXR agonist that interacts via H-bond formation with the His298 and ASN287 residues. It is utilized in research focused on primary biliary cirrhosis (PBC), primary sclerosing cholan...
T65387 Paromomycin, sulfate (1:1)
Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven...
Cat No. Product Name Synonyms Targets
T8117 Metenolone acetate Methenolone acetate Others , Androgen Receptor
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.
T5233 N-Methylnicotinamide N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide Others , Endogenous Metabolite
N-Methylnicotinamide (Nicotinic Acid Methylamide) is a metabolite of niacin (or nicotinamide) and is commonly found in human urine. However low levels of urinary excretion of N-Methylnicotinamide (Nicotinic Acid Methylam...
T2532 Tauroursodeoxycholate Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode...
T3753 Sinapinic Acid Sinapic acid,Synapoic acid Apoptosis , RAAS , Reactive Oxygen Species , HDAC
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...
T37177 Norcholic Acid
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of met...
T7475 S-Adenosyl-L-methionine AdoMet,Ademetionine,SAMe,S-Adenosyl methionine Others , Endogenous Metabolite
S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.

Natural Products

Metenolone acetate
T8117
Synonym: Methenolone acetate
Target: Others, Androgen Receptor
N-Methylnicotinamide
T5233
Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide
Target: Others, Endogenous Metabolite
Tauroursodeoxycholate
T2532
Synonym: Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA
Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite
Sinapinic Acid
T3753
Synonym: Sinapic acid,Synapoic acid
Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC
Norcholic Acid
T37177
Synonym:
Target:
S-Adenosyl-L-methionine
T7475
Synonym: AdoMet,Ademetionine,SAMe,S-Adenosyl methionine
Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：
Human (9)
HBV-D (3)
Mouse (3)
Rat (2)
Cynomolgus (1)
Expression System：
HEK293 (13)
E. coli (3)
Human Cells (2)
Tag：
His (4)
C-His (3)
C-hFc (2)
N-terminal 6xHis-SUMO-tagged (2)
hFc (2)
C-6His (1)
C-Fc (1)
C-His-Avi (1)
N-terminal 10xHis-tagged (1)
mFc (1)
Cat No. Product Name Species Expression System
TMPY-04874 IL-23 P19/IL23A Protein, Human, Recombinant (hFc) Human HEK293
IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, t...
TMPY-02500 YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) Mouse HEK293
Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC c...
TMPY-01304 YKL-40/CHI3L1 Protein, Human, Recombinant (His) Human HEK293
Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC c...
TMPY-00915 Serpin A1 Protein, Human, Recombinant (His) Human HEK293
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...
TMPK-00587 CDH11 Protein, Human, Recombinant (aa 54-617, His) Human HEK293
CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis. CDH11 expression was...
TMPK-01284 Syndecan-1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPK-00593 Syndecan-1 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPK-00594 Syndecan-1 Protein, Human, Recombinant (aa 23-254, hFc) Human HEK293
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPK-00201 Syndecan-1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPK-00595 Syndecan-1 Protein, Human, Recombinant (aa 23-254, His) Human HEK293
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on th...
TMPJ-00302 Serpin F2 Protein, Mouse, Recombinant (hFc) Mouse Human Cells
Alpha-2-antiplasmin, also called Serpin F2, is a serine protease inhibitor (serpin) responsible for inactivating plasmin, and an important enzyme participates in fibrinolysis and degradation of other proteins. In liver c...
TMPY-04987 IL-23 P19/IL23A Protein, Human, Recombinant (mFc) Human HEK293
IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, t...
TMPJ-00505 Serpin A1 Protein, Human, Recombinant (aa 25-418, His) Human Human Cells
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent,...
TMPH-00806 HBV-D (isolate Germany/1-91/1991) Protein X (His & SUMO) HBV-D E. coli
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and ...
TMPY-02810 Ninjurin-1 Protein, Rat, Recombinant (hFc) Rat HEK293
Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia c...
TMPH-00807 HBV-D subtype ayw (isolate France/Tiollais/1979) Protein X (His & SUMO) HBV-D E. coli
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and ...
TMPH-00808 HBV-D subtype ayw (isolate Japan/JYW796/1988) Protein X (His) HBV-D E. coli
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and ...
TMPY-00442 Serpin A1 Protein, Rat, Recombinant (His) Rat HEK293
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...
IL-23 P19/IL23A Protein, Human, Recombinant (hFc)
TMPY-04874
Species: Human
Expression System: HEK293
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)
TMPY-02500
Species: Mouse
Expression System: HEK293
YKL-40/CHI3L1 Protein, Human, Recombinant (His)
TMPY-01304
Species: Human
Expression System: HEK293
Serpin A1 Protein, Human, Recombinant (His)
TMPY-00915
Species: Human
Expression System: HEK293
CDH11 Protein, Human, Recombinant (aa 54-617, His)
TMPK-00587
Species: Human
Expression System: HEK293
Syndecan-1 Protein, Cynomolgus, Recombinant (His)
TMPK-01284
Species: Cynomolgus
Expression System: HEK293
Syndecan-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00593
Species: Human
Expression System: HEK293
Syndecan-1 Protein, Human, Recombinant (aa 23-254, hFc)
TMPK-00594
Species: Human
Expression System: HEK293
Syndecan-1 Protein, Mouse, Recombinant (hFc)
TMPK-00201
Species: Mouse
Expression System: HEK293
Syndecan-1 Protein, Human, Recombinant (aa 23-254, His)
TMPK-00595
Species: Human
Expression System: HEK293
Serpin F2 Protein, Mouse, Recombinant (hFc)
TMPJ-00302
Species: Mouse
Expression System: Human Cells
IL-23 P19/IL23A Protein, Human, Recombinant (mFc)
TMPY-04987
Species: Human
Expression System: HEK293
Serpin A1 Protein, Human, Recombinant (aa 25-418, His)
TMPJ-00505
Species: Human
Expression System: Human Cells
HBV-D (isolate Germany/1-91/1991) Protein X (His & SUMO)
TMPH-00806
Species: HBV-D
Expression System: E. coli
Ninjurin-1 Protein, Rat, Recombinant (hFc)
TMPY-02810
Species: Rat
Expression System: HEK293
HBV-D subtype ayw (isolate France/Tiollais/1979) Protein X (His & SUMO)
TMPH-00807
Species: HBV-D
Expression System: E. coli
HBV-D subtype ayw (isolate Japan/JYW796/1988) Protein X (His)
TMPH-00808
Species: HBV-D
Expression System: E. coli
Serpin A1 Protein, Rat, Recombinant (His)
TMPY-00442
Species: Rat
Expression System: HEK293
Cat No. Product Name
L6750 PBCRBS Traditional Chinese Medicine Compound Library

588 compounds
A unique collection of 588 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis.

Libraries

PBCRBS Traditional Chinese Medicine Compound Library
L6750
Compounds: 588
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