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Cat No. | Product Name | Synonyms | Targets |
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T28537 | Ricasetron | Brl 46470,Brl46470,Brl-46470 | 5-HT Receptor |
Ricasetron (Brl 46470) is a 5-HT3 receptor antagonist with pro-axonal lysis and antiemetic properties, and is used in the study of anxiety and anxiety disorders. | |||
T23444 | TCS 1105 | N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide | Others |
TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice. | |||
T8860 | DSRM-3716 | Androgen Receptor | |
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons. | |||
T1880 | P7C3 | Others | |
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be... | |||
T70647 | CD2019 | ||
CD2019 is a retinoic acid receptor beta (rarbeta) agonist, overcoming inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. | |||
T26230 | Stilbamidine dihydrochloride | NSC 35605,NCI 174 | |
Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction used to study the distribution of the drug in the organs and tissues of rats following intravenous injection. | |||
T37733 | AMP-PNP tetralithium | ||
Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules. Brady (1985) A novel brain ATPase with properties expect... | |||
TP1989 | NEP(1-40) | Nogo-66 (1-40) | |
Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS ... | |||
T29809 | AL-1 | AL 1,AL1 | |
AL-1 is a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It can mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It exists in a variet... | |||
T13691 | Etifoxine | HOE 36-801 | Others |
Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. GABAA receptor Etifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine ac... | |||
T83326 | 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium | ||
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium, a fluorescent dye, is utilized for retrograde axonal transport demonstration, secondary antibody labeling, and as a whole cell stain [1]. | |||
T38214 | 1-Deoxysphingosine (m18:1(4E)) | 1-Deoxysphingosine (m18:1(4E)) | |
1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine durin... | |||
T41193 | FFN 270 | ||
FFN 270 is a fluorescent false neurotransmitter (FFN). Fluorescent substrate for NET and VMAT2. Labels noradrenergic neurons and their synaptic vesicles, and enables imaging of synaptic vesicle content release from speci... | |||
T62965 | TDP1 Inhibitor-2 | ||
TDP1 Inhibitor-2 is a potent inhibitor of TDP1 (tyrosyl-DNA phosphodiesterase 1) (IC50: 99 nM) and inhibits SCAN1 (spinal cerebellar ataxia syndrome with axonal neuropathy) (IC50: 3.5 μM). | |||
T82798 | C3bot(154-182) TFA | ||
C3bot(154-182) TFA, a C3 peptide, facilitates spinal cord injury recovery by promoting regenerative growth of descending fiber tracts. It serves as a potential therapeutic agent to support axonal protection and/or repair... | |||
T36781 | St-Ht31 P | st-Ht31 P | |
Negative control for st-Ht31 . Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID:28192412 |Vijayaraghavan et al (1997) Protein kinase A-a... | |||
T80420 | TAT-NEP1-40 acetate | Apoptosis | |
TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose deprivation (OGD) and encourages neurite outgrowth. This compound al... | |||
T80544 | PTPσ Inhibitor, ISP | Phosphatase | |
PTPσ Inhibitor ISP is a compound that binds to recombinant human PTPs, thereby inhibiting PTPσ signaling. It has the capability to penetrate membranes and counteract the inhibitory effects of chondroitin sulfate proteogl... | |||
T80418 | TAT-NEP1-40 | Apoptosis | |
TAT-NEP1-40, a blood-brain barrier (BBB) permeable peptide, confers protection to PC12 cells against oxygen and glucose deprivation (OGD) while promoting neurite outgrowth. Furthermore, it enhances neurologic outcomes po... | |||
T80419 | TAT-NEP1-40 TFA | Apoptosis | |
TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth. Additionally, it enhances neurological outcomes post-ischemia by... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02860 | TAG1/Contactin 2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TAG1/Contactin 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 108.7 kDa and the accession number is Q61330. | |||
TMPY-00721 | TAG1/Contactin 2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TAG1/Contactin 2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 109 kDa and the accession number is A1ML24. | |||
TMPY-03425 | Tau Protein, Human, Recombinant (His) | Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are... | |||
TMPY-05510 | BDNF Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B... | |||
TMPH-01675 | Meteorin Protein, Human, Recombinant (His) | Human | E. coli |
Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in sma... | |||
TMPH-01610 | LINGO1 Protein, Human, Recombinant (His) | Human | E. coli |
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of ... | |||
TMPH-02753 | LINGO1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of ... | |||
TMPH-01683 | Tau Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com... | |||
TMPK-00917 | PLXNA1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
PlexinA1 (PlxnA1) is a transmembrane receptor for semaphorins, a large family of proteins that act as axonal guidance cues during nervous system development. | |||
TMPJ-01401 | NTNG1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Netrin-G1, known as NTNG-1, and is a member of the UNC-6/Netrin family of proteins. The NTNG1 gene is located on chromosome 1p13.3 and encodes a glycosylphosphatidylinositol protein anchored to the presynaptic membrane. ... | |||
TMPJ-00295 | NgR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a recept... | |||
TMPY-03185 | METRN Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
METRN (Meteorin, Glial Cell Differentiation Regulator) is a Protein Coding gene. The encoded protein belongs to the meteorin family. It is broadly expressed in the brain, kidney, and other tissues. Meteorin is a novel se... | |||
TMPH-01256 | Dystonin Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc... | |||
TMPH-01257 | Dystonin Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc... | |||
TMPH-01844 | Paralemmin-1/PALM Protein, Human, Recombinant (His) | Human | E. coli |
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylatio... | |||
TMPH-01595 | KMO Protein, Human, Recombinant (His) | Human | E. coli |
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA r... | |||
TMPK-01200 | Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RT... | |||
TMPH-02430 | SNCG Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent prote... | |||
TMPJ-01349 | SEMA4B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. SEMA4B is a single-pass type I membrane protein and contains one Ig-like C2-type (immunoglobulin-like) domai... | |||
TMPK-00109 | Artemin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored... | |||
TMPH-01370 | SNCG Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent prote... | |||
TMPK-01062 | RGMC Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C),both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A... | |||
TMPY-03392 | CKAP1/TBCB Protein, Human, Recombinant (His) | Human | E. coli |
Tubulin-folding cofactor B, also known as TBCB, belongs to the TBCB family. It contains 1 CAP-Gly domain and can be detected in most tissues. TBCB binds to alpha-tubulin folding intermediates after their interaction with... | |||
TMPH-01754 | L1CAM Protein, Human, Recombinant (His & Myc) | Human | HEK293 Cells |
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neu... | |||
TMPJ-00706 | SNCG Protein, Human, Recombinant | Human | E. coli |
Gamma-Synuclein (SNCG) is a member of the Synuclein protein family. Gamma-Synuclein is mostly expressed in the peripheral nervous system and retina. Gamma-Synuclein plays a role in neurofilament network integrity and may... | |||
TMPK-00495 | CADM3 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Cell adhesion molecules belonging to the Cadm family, and in particular Cadm3 (axonal) and its heterophilic binding partner Cadm4 (Schwann cell), mediate these interactions along the internode.over-expressing Cadm3 on th... | |||
TMPJ-00827 | Tau-D Protein, Human, Recombinant (His) | Human | E. coli |
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. ... | |||
TMPJ-00383 | SEMA3A Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells |
emaphorin-3A is a secreted protein which belongs to the semaphorin family. Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 500 aa Sema domain.This protein can f... | |||
TMPY-03406 | NMNAT1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to pro... | |||
TMPJ-01348 | SEMA4B Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells |
Semaphorin-4B is a single-pass type I membrane protein. SEMA4B is a member of the semaphorin family. The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. SEMA4B ... | |||
TMPJ-00587 | NRCAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily.... | |||
TMPJ-01130 | NPTX1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a... | |||
TMPJ-00358 | DR6 Protein, Mouse, Recombinant (hFc & His) | Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may ... | |||
TMPY-00134 | Netrin G1/NTNG1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
NTNG1 (Netrin G1) is a Protein Coding gene. This gene encodes a preproprotein that is processed into a secreted protein containing eukaryotic growth factor (EGF)-like domains. NTNG1 is broadly expressed in the brain, kid... | |||
TMPJ-01169 | SEMA4A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Semaphorin-4A (SEMA4A) belongs to the semaphorin family which contains a Ig-like C2-type domain, a PSI domain and a Sema domain. SEMA4A is expressed from day 10 in the embryo, and low levels are found between days 10-12.... | |||
TMPJ-01279 | TAFA4 Protein, Human, Recombinant (His) | Human | E. coli |
FAM19A4 is a secreted, 12 kDa member of the FAM19/TAFA family of chemokine-like proteins. Like other members of the FAM19/TAFA family, with the exception of TAFA5, mature FAM19A4 contains 10 regularly spaced cysteine res... | |||
TMPH-02878 | PTPRS Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects... | |||
TMPY-03255 | ROBO2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ROBO2 belongs to the ROBO family. Members of the ROBO family are a group of highly conserved transmembrane glycoproteins that make up a small subgroup of the immunoglobulin (Ig) superfamily. They are best known for their... | |||
TMPJ-00277 | NgR3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Nogo-66 Receptor-Related Protein 3 (NgR3) has primary structures with NgR2 (NgRH1, NgRL3) and biochemical properties that are homologous to Nogo-66 receptor (NgR), and constitute a novel neuronal receptor protein family.... | |||
TMPY-02946 | TAFA2/FAM19A2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
FAM19A2 belongs to the FAM19/TAFA family. FAM19/TAFA family members are chemokine-like proteins. The biological functions of TAFA family members remain to be determined, but there are a few tentative hypotheses. First, T... | |||
TMPY-02106 | GAP43 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / G... | |||
TMPY-02025 | CPLX2 Protein, Human, Recombinant (His) | Human | E. coli |
Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate t... | |||
TMPH-02873 | RAB10 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou... | |||
TMPJ-00395 | SEMA4D Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous t... | |||
TMPY-01576 | Artemin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored... |
Cat No. | Product Name | ||
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L7700 | Neural Regeneration Compound Library | 524 compounds | |
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening; |