anaerobic bacteria

Ertapenem sodium (MK-826) is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases.

Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.

Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci, enterococci and streptococci, as well as anaerobic bacteria.

Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.

Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa.

Meropenem (SM 7338) is a synthetic carbapenem antibiotic with broad-spectrum antibacterial activity. It exerts a bactericidal effect by inhibiting the synthesis of peptidoglycan in the bacterial cell wall and is active against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria. Meropenem is active against both susceptible and resistant Neisseria gonorrhoeae (MIC values of 0.02–0.06 mg/mL), Haemophilus influenzae (MIC: 0.03–0.12 mg/mL), and Klebsiella pneumoniae (MIC: 0.015–0.12 mg/mL). Meropenem can be used for constructing bacterial infection models and screening for antimicrobial activity.

Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

Metronidazole Benzoate (Benzoyl metronidazole) is a derivative of Metronidazole and benzoic acid, which has antibacterial, anti-parasitic and anti-trichomonas functions and is often used to treat infections caused by anaerobic bacteria.

Lincomycin hydrochloride (U10149A) is a lincosamide antibiotic identified in S.lincolnensis with activity against gram-positive cocci and anaerobic bacteria.

Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria.

Cefepime (BMY-28142) is a cephalosporin antibiotic with antimicrobial activity, induces neurotoxicity, inhibits both Gram-positive and Gram-negative, and can be used in the study of anaerobic bacteria.

Morinidazole shows antibacterial activity and can be used in studies about bacterial infections research such as appendicitis and pelvic inflammatory disease caused by anaerobic bacteria.

Clinafloxacin (CI-960)(PD-127391) is a fluoroquinolone antibiotic.

UG-FA 132 is a compound with potent antibacterial properties, effective against both Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa and lactose-producing strains, while also exhibiting strong inhibitory effects on anaerobic bacteria.

Omadacycline tosylate (PTK 0796 tosylate) is an orally administered aminocyclitol antibacterial agent and tetracycline antibiotic exhibiting broad-spectrum antimicrobial activity against Gram-positive, Gram-negative, anaerobic, and atypical pathogens. Omadacycline tosylate binds to the 30S ribosomal subunit of bacteria to inhibit protein synthesis and may be employed in studies of pneumonia and cutaneous infections.

Apalcillin (PC-904) combined with Ro 48-1220 (a penicillin sulfone β-lactamase inhibitor) exhibits broad-spectrum activity against Gram-negative aerobic and anaerobic bacteria, excluding Klebsiella acid-producing strains. This combination shows strong efficacy against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae with an effective MIC of 11 μg/mL. Additionally, it inhibits Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter at low MICs (0.25 to 4 μg/mL). However, it has limited efficacy against oxacillin-resistant staphylococci and some Gram-positive bacteria. Apalcillin/Ro 48-1220's effectiveness against certain extended-spectrum β-lactamase-producing Escherichia coli is comparable to piperacillin/tazobactam, though it is less effective against SHV-type β-lactamases.

Ranbezolid (RBx7644 free base) is an orally active oxazolidinone antibiotic effective against both Gram-positive and Gram-negative anaerobic bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, and Bacteroides fragilis. It inhibits the 50s ribosomal subunit, with an IC50 value of 17 μM for bacterial ribosomes, and disrupts cell wall and lipid synthesis. Ranbezolid acts as a rapid bactericidal agent, significantly reducing bacterial load, and demonstrates improved cardiovascular safety. It is applicable in the study of antibiotics targeting anaerobic bacteria.

Ranbezolid (RBx7644 free base) is an orally effective oxazolidinone antibiotic targeting Gram-positive and Gram-negative anaerobes, such as Staphylococcus aureus, Staphylococcus epidermidis, and Bacteroides fragilis. It inhibits the 50S ribosomal subunit with an IC50 of 17 μM for bacterial ribosomes. Ranbezolid also disrupts cell wall and lipid synthesis. This compound acts rapidly as a bactericidal agent, significantly reducing bacterial load while offering improved cardiovascular safety. Ranbezolid is applicable in research on antibiotics against anaerobic bacteria.

Cefotetan Sodium, a second-generation cephalosporin, cephamycin antibiotic, is active against a wide range of both aerobic and anaerobic gram-negative and gram-positive bacteria. Cefotetan disrupts the cell wall synthesis by binding to penicillin-binding

BAY-Y 3118 hydrochloride is a quinolone antibacterial agent with a broad spectrum of activity in vitro. It exhibits high efficacy against Gram-positive cocci and anaerobic bacteria, and shows moderate activity against Enterobacteriaceae and Pseudomonas aeruginosa. BAY-Y 3118 hydrochloride is utilized for research into infectious diseases.

YM 133 (IMC-XV) is a semi-synthetic macrolide antibiotic with potent bactericidal activity. It is effective against strains of staphylococci, streptococci, Bacteroides, and Clostridia that are resistant to erythromycin, josamycin, and rokitamycin (MIC≥ 100 μg/mL). Additionally, YM 133 exhibits excellent activity against macrolide-resistant strains and anaerobic bacteria, making it valuable for antibacterial research.

Piperacillin mixture with tazobactam (8:1) is a combination antibiotic known as Piperacillin-Tazobactam, formulated at an 8:1 ratio. This β-lactam/β-lactamase inhibitor duo exhibits broad-spectrum antibacterial activity, effective against a wide range of Gram-positive, Gram-negative aerobic, and anaerobic bacteria, including many pathogens that produce β-lactamase.

Sancycline is a semi-synthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (MIC90s = 1 and 32 μg/ml, respectively).

E 4441 is a third-generation difluoroquinolone, which has good activity against G(+) aerobic bacteria and anaerobic bacteria in vitro and in vivo.