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Cat No. | Product Name | Synonyms | Targets |
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T9020 | GSK620 | Epigenetic Reader Domain | |
GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD... | |||
T22408 | Proflavine | 3,6-Diaminoacridine | Antibacterial |
Proflavine (3,6-Diaminoacridine) (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria and is a topical antiseptic used mainly in wound dressings. | |||
T8372 | VU0134992 | VU 0134992 | Potassium Channel |
VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM | |||
T12997 | SR-318 | p38 MAPK , TNF | |
SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti-inflammatory activity. | |||
T13316 | VU0134992 hydrochloride | Potassium Channel | |
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 µM). | |||
T0438 | Proflavine Hemisulfate | 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate | Others , Potassium Channel , DNA , Thrombin , Antibacterial , Autophagy |
Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and a... | |||
T14975 | CJ-42794 | CJ-042794 | Others |
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... | |||
T6658 | SB-408124 | OX Receptor | |
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. | |||
T32824 | LM-1685 | LM 1685,LM1685 | COX |
LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation. | |||
T31213 | Dazmegrel | UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485 | PPAR |
Dazmegrel (UK 38,485) is a potent and specific thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy. | |||
T10866 | Cot inhibitor-2 | TNF , MAPK | |
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM. | |||
T4367 | Mycro 3 | Mycro-3 | c-Myc , Autophagy |
Mycro 3 is potent and selective for c-Myc in whole cell assays. | |||
T77747 | Adecatumumab | MT 201 | Others |
Adecatumumab (MT201) is a whole-person IgG1 monoclonal antibody to human EpCAM. Adecatumumab has potential anticancer activity and can be used to study breast cancer. | |||
T77018 | Garadacimab | CSL312 | Factor Xa |
Garadacimab (CSL312) is a potent whole-human IgG4 monoclonal antibody targeting activation factor XII (FXIIa). Garadacimab can be used to study hereditary angioedema. | |||
T76874 | Erenumab | AMG-334 | CGRP Receptor |
Erenumab is a whole-human monoclonal antibody. Erenumab inhibits calcitonin gene-related peptide (CGRP) receptors. Erenumab can be used to prevent migraine attacks. | |||
T16383 | Olinciguat | IW-1701 | Guanylate cyclase |
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay. | |||
T10865L | Cot inhibitor-1 hydrochloride | Cot inhibitor-1 hydrochloride(915365-57-0 Free base) | TNF , MAPK |
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 = 5.7 nM). | |||
T37891L | GLP-1(32-36)amide acetate | GLP-1(32-36)amide acetate(1417302-71-6 Free base) | Others |
GLP-1(32-36)amide acetate is a pentapeptide and derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide acetate could inhibit weight gain and modulate whole body glucose metabolism in diabetic... | |||
T11149 | Ecopladib | PLA 725 | Phospholipase |
Ecopladib (PLA 725) is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively. | |||
T77019 | Garetosmab | REGN 2477 | TGF-beta/Smad |
Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cancer activity and can be used to study ossifying fibrous dyspl... | |||
T68155 | Tebufelone | Prostaglandin Receptor , LTR | |
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticul... | |||
T22698 | TLR3-IN-1 | CU CPT 4a | TLR |
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell... | |||
T3631 | PF-8380 | PDE | |
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib... | |||
T10865 | Cot inhibitor-1 | TNF , MAPK | |
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a... | |||
T23394 | SR 57227A | SR 57227 hydrochloride | 5-HT Receptor |
SR 57227A (SR 57227 hydrochloride) is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 rece... | |||
T76870 | Narsoplimab | OMS 721 | SARS-CoV |
Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 and prevents lectin pathway ac... | |||
T61933 | MK-0159 | ||
MK-0159 (compound 37) is a CD38 inhibitor with oral activity and selectivity. MK-0159 can inhibit CD38 in humans, mice and rats, with IC50 of 22, 3 and 70 nM respectively. MK-0159 showed good stability in human and roden... | |||
T9495 | Haloxyfop methyl ester | Others | |
Methyl 2-(4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoate is a selective herbicide, an inhibitor of fatty acid synthesis, and has a systemic effect. After the stem and leaves are treated, it is quickl... | |||
T36503 | Sodium Hydrogen Sulfide (hydrate) | Others | |
Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sul... | |||
T0463 | Loxoprofen | Loxoprofene,Loxoprofeno,Koloxo | COX |
Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine. | |||
T14374 | AZD2906 | ||
AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and ... | |||
T12844 | SB-408124 Hydrochloride | Others | |
SB-408124 Hydrochloride is a non-peptide OX1 receptor antagonist(Ki of 57 nM and 27 nM in both whole cell and membrane, respectively). | |||
T34580 | Schweinine | ||
Schweinine is a macrocylic alkaloid isolated from the whole plant of Schweinfurthia papilionacea. | |||
T31432 | Dicarboxidine | ||
Dicarboxidine can be used in immunochromatographic assay of theophylline in whole blood. | |||
T30990 | CMFDA | 5-Chloromethylfluorescein diacetate,Cell Tracker Green,CM-FDA,CM FDA | |
CMFDA can be used as a fluorescent whole-cell-tracking reagent. | |||
T61446 | BioA-IN-13 | ||
BioA-IN-13 is a highly effective inhibitor of the Mycobacterium tuberculosis BioA enzyme, displaying potent cell permeability and whole-cell activity [1]. | |||
T14381 | AZD7624 | AZD-7624 | p38 MAPK , TNF |
AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity. | |||
T24307 | L 652343 | L652343,L 652,343,L652,343,L-652,343,L-652343 | |
L 652343 is an inhibitor of cyclooxygenase and 5-lipoxygenase in vitro. It also inhibits the synthesis of the products of both these pathways in whole cells. | |||
T23155 | Piefeltarraenin ⅠB | Others | |
Piefeltarraenin ⅠB is extracted from the whole herb of Picriafel-terrae Lour. | |||
T33424 | MK-0952 | MK 0952 | |
MK-0952 is a selective PDE4 inhibitor used to treat long-term memory loss and mild cognitive impairment. It is an intrinsically potent inhibitor and has shown limited whole blood activity. | |||
T35725 | 4-hydroxy Valsartan | ||
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood. | |||
T40650 | Dihydroisopimaric acid | ||
Dihydroisopimaric acid activates BK channels alphabeta1, which are large conductance Ca 2+ activated K + channels. This compound directly measures the opening of BKalphabeta1 under a whole-cell voltage clamp. | |||
T38138 | ACEA | 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide | |
Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces ... | |||
T11243 | Ethyl tosylcarbamate | Others | |
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). | |||
T33407 | MitoEbselen-2 chloride | MitoPeroxidase-2,MitoPeroxidase 2,MitoEbselen 2,MitoEbselen-2 | |
MitoEbselen-2 is a radiation mitigator which reduces lipid hydroperoxides and prevents apoptotic cell death. When administered 24 hours postirradiation, MitoEbselen-2 was shown to increase the survival of mice exposed to... | |||
T38266 | Nirogacestat dihydrobromide | ||
Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmaco... | |||
T21189 | 2-Methyldecanenitrile | 2-Cyanodecane | |
2-Methyldecanenitrile, a component in a perfume composition, has an intense peach character with lactonic undertones. It is stable across the whole pH range, allowing the creation of a stable fruity effect at low concent... | |||
T70554 | Chaetomellic acid A | ||
Chaetomellic acid A is a potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and I... | |||
T24188 | J-104871 | UNII-6137X5QNJF,J 104871 | |
J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-trans... | |||
T26447 | A 78773 | A78773,A-78773 | |
A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tis... |
Cat No. | Product Name | Synonyms | Targets |
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TN2079 | (-)-Pinoresinol | Others , TNF , NF-κB , COX | |
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb. | |||
T3S0693 | Blinin | Others | |
Blinin, isolated from the whole plant of Conyza blinii, is used in folk medicine in the south-west of China. | |||
TN7077 | Sinocrassoside C1 | Others | |
Sinocrassoside C1 is the methanolic extract of the whole plant of Sinocrassula indica (Crassulaceae), six new flavonol glycosides | |||
T5730 | MALTOHEXAOSE | Amylohexaose | Others , Endogenous Metabolite |
Maltohexaose (Amylohexaose) is a natural saccharide, and can be produced from amylose, amylopectin and whole starch. | |||
T2758 | Madecassic acid | 6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose | Others , TNF , COX , NO Synthase , Interleukin |
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica. | |||
T0570 | 3,5-Dihydroxybenzoic acid | Others , Endogenous Metabolite | |
3,5-Dihydroxybenzoic Acid is a metabolite of alkylresorcinol in human urine and plasma. It is also used as a biomarker of whole grain wheat and rye. | |||
T4785 | Oxfenicine | 4-Hydroxy-L-phenylglycine | Others |
Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistanc... | |||
T2985 | Gypenoside XLIX | PPAR | |
Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition | |||
TN1433 | Batatasin III | FAK , Others , Akt | |
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-... | |||
T4716 | Pyrrole-2-carboxylic acid | 2-Pyrrolecarboxylic acid,Minaline | Endogenous Metabolite |
Pyrrole-2-carboxylic acid (Minaline) was first identified as a degradation product of sialic acids, then as a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. The latter rela... | |||
T36914 | 2-Hydroxyanthraquinone | Others | |
2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively)... | |||
TN1016 | Kukoamine A | NF-κB , Lipoxygenase , DNA/RNA Synthesis , Parasite | |
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) i... | |||
T7786 | Tryptanthrin | DNA gyrase | |
Tryptanthrin is a natural DNA gyrase inhibitor. | |||
TN4297 | Isohomoarbutin | Others | |
Isohomoarbutin is a natural product from the whole herb of Pyrola rotundifolia (Pyrolaceae). | |||
T3242 | Breviscapin | Scutellarin,Scutellarin B | Others |
Breviscapin (Scutellarin)e is the total flavonoid components (the content of scutellarin > or =85%) extracted from the dried whole plant of Erigeron breviscapus. | |||
TN5661 | 1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one | ||
1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one shows strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. | |||
T40193 | Ebeiedinone | ||
Ebeiedinone, a steroidal alkaloid derived from Fritillaria species, effectively inhibits the activity of human whole blood cholinesterase (ChE) at a concentration of 0.1 mM, resulting in a significant inhibitory effect o... | |||
T81956 | Ladanetin-6-O-β-(6′′-O-acetyl)glucoside | ||
Ladanetin-6-O-β-(6′′-O-acetyl)glucoside, a flavonoid extracted from Dracocephalum tanguticum whole plants, exhibits antioxidant properties and cardioprotective effects, mitigating Doxorubicin-induced toxicity in H9c2 cel... | |||
T80002 | Wulfenioidin F | Virus Protease | |
Wulfenioidin F, a diterpenoid isolated from the whole plant of Orthosiphon wulfenioides, exhibits anti-Zika virus (ZIKV) activity with an EC50 of 8.07 μM and hinders virus replication by inhibiting the expression of the ... |
Cat No. | Product Name | Species | Expression System |
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TMPH-01709 | Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. | |||
TMPH-00896 | Human adenovirus C serotype 2 DNA-binding protein (His) | HAdV-2 | E. coli |
Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Relea... | |||
TMPY-00184 | Xg blood group Protein, Human, Recombinant (His) | Human | HEK293 |
XG, Gene ID 7499, stands for Xg glycoprotein or Xg blood group. The XG blood group system includes 2 antigens: Xga and CD99 (encoded by the MIC2 gene). The XG blood group is the first blood group mapped to the human X ch... | |||
TMPH-00898 | Human adenovirus C serotype 5 DNA-binding protein (His) | HAdV-5 | Baculovirus |
Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Relea... | |||
TMPY-02306 | MAB21L2 Protein, Human, Recombinant (His & ZZ) | Human | E. coli |
MAB21L2 (Mab-21 Like 2) is a Protein Coding gene. It encodes a protein similar to C. elegans mab-21 cell fate-determining factor. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localizat... | |||
TMPY-05029 | INHBE Protein, Human, Recombinant (hFc) | Human | HEK293 |
INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to gen... | |||
TMPH-03735 | Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc) | ZEBOV | E. coli |
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras... | |||
TMPH-02384 | Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc) | MARV | E. coli |
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras... | |||
TMPH-03734 | Zaire ebolavirus (strain Mayinga-76) L Protein (His) | ZEBOV | E. coli |
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras... | |||
TMPH-03741 | BoNT/F Protein, Clostridium botulinum, Recombinant (His) | Clostridium botulinum | E. coli |
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequen... |
Cat No. | Product Name | ||
---|---|---|---|
L1500 | GPCR Compound Library | 1940 compounds | |
A unique collection of 1940 GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target identification and research; | |||
L4000 | Bioactive Compound Library | 14590 compounds | |
A collection of 14590 small molecule compounds with validated activity for high throughput screening (HTS), high content screening (HCS), cell induction, and target identification; | |||
L2190 | Anti-Lung Cancer Compound Library | 1735 compounds | |
A unique collection of 1735 compounds with anti-lung cancer therapeutic activity or targeting lung cancer’s major signaling pathways, can be used for anti-lung cancer drug discovery and mechanism study; |