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Cat No. | Product Name | Synonyms | Targets |
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T3502 | C29 | TLR | |
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. | |||
T38361 | GSK717 | IL Receptor , NOD | |
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio... | |||
T6716 | Valsartan | Diovan,Tareg,CGP 48933 | RAAS |
Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension. | |||
T15020 | CU-CPT22 | TLR | |
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) ... | |||
T76975 | Tomaralimab | OPN-305 | TLR |
Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS). | |||
T15017 | CU-T12-9 | TLR | |
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat... | |||
T34249 | Rabeximod | ROB-803 | TLR |
Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by stimulating TLR2 and TLR4 downstream to block the activatio... | |||
T2897 | (Rac)-Shikonin | (±)-Shikonin,Alkanet extract,Anchusin,Anchusa acid | Others |
(Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics,... | |||
T4958 | (-)-Alkannin | Alkannin,Shikonin | Apoptosis , PI3K |
(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, a... | |||
T3795 | Corilagin | Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy | |
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B... | |||
T16123 | MMG-11 | Others | |
MMG-11 inhibits both TLR2/1 and TLR2/6 signaling (IC50s: 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses). MMG-11 is an effective and selective human TLR2 antagonist with low cytotox... | |||
T74890 | Diprovocim-X | ||
Diprovocim-X (compound 35), a robust TLR1/TLR2 (toll-like receptor 1/2) agonist, exhibits EC 50 values of 0.14 nM for hTLR1/TLR2 and 0.75 nM for mTLR1/TLR2. As a potent in vivo adjuvant in mice, it effectively stimulates... | |||
T26626 | AN3485 Hydrochloride | ||
AN3485 Hydrochloride inhibits TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6. | |||
T27191 | D-Mannuronic Acid | ||
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB. | |||
T38261 | Sparstolonin B | ||
Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacologic... | |||
T60763 | MMG-11 quarterhydrate | ||
MMG-11 quarterhydrate is a potent and selective antagonist of human TLR2 which inhibits both TLR2/1 and TLR2/6 signaling with low cytotoxicity. The IC 50 s of MMG-11 quarterhydrate for Pam 3 CSK 4 -induced hTLR2/1 and f... | |||
TP1962 | Pam2CSK4 | ||
Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells. | |||
T35701 | FSL-1 TFA | ||
FSL-1 TFA, a toll-like receptor 2/6 (TLR2/6) agonist derived from bacteria, bolsters resistance against experimental HSV-2 infection[1] and stimulates MMP-9 production via the TLR2 and NF-κB/AP-1 signaling pathways in mo... | |||
T74230 | Dioleoylphosphatidylglycerol | ||
Dioleoylphosphatidylglycerol (DOPG), a naturally occurring phospholipid, is synthesized through the action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). It functions to suppress the production of inflammatory mediat... | |||
TP2282L | Pam2CSK4 TFA | PUL-042 TFA,ODN-M362 TFA,Pam2CSK4 trifluoroacetate-salt,Pam2CSK4 TFA(868247-72-7 Free base) | TLR , Antifungal |
Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the p... |