Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • PLK
    (27)
  • Apoptosis
    (9)
  • Aurora Kinase
    (5)
  • CDK
    (4)
  • PI3K
    (3)
  • Autophagy
    (2)
  • FLT
    (2)
  • PDGFR
    (2)
  • Serine/threonin kinase
    (2)
  • Others
    (26)
Filter
Search Result
Results for "

PLK1 Inhibitor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    66
    TargetMol | Inhibitors_Agonists
  • Natural Products
    2
    TargetMol | Natural_Products
  • Cell Research
    1
    TargetMol | Inhibitors_Agonists
MLN0905
PLK1 Inhibitor
T27041228960-69-7
MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).
  • Inquiry Price
Size
QTY
CCB02
T107042100864-57-9In house
CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity, showing no inhibition on cell cycle- and centrosome-related kinases, nor affecting the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.
  • Inquiry Price
6-8 weeks
Size
QTY
3mb-pp1
T21678956025-83-5In house
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifically inhibits analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase with IC50 of 2 μM. 3MB-PP1 can be used for the research of cell division and hypha formation of Candida albicans.
  • Inquiry Price
Size
QTY
Poloxin-2
Poloxin2, Poloxin 2
T25969321695-37-8In house
Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.
  • Inquiry Price
6-8 weeks
Size
QTY
T521
T 521
T28904891020-54-5In house
T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.
  • Inquiry Price
8-10 weeks
Size
QTY
TargetMol | Inhibitor Sale
Plogosertib
CYC140
T713991137212-79-3In house
Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors.
  • Inquiry Price
8-10 weeks
Size
QTY
AAPK-25
T102152247919-28-2
AAPK-25 is a potent and selective Aurora PLK dual inhibitor with anti-tumor activity, causing mitotic delay and arresting cells in prometaphase, followed by increased apoptosis. It targets Aurora-A -B -C with Kd values ranging from 23-289 nM.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
GW843682X
GW843682
T15454660868-91-7
GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
  • Inquiry Price
4-6 weeks
Size
QTY
Volasertib
BI 6727
T6019755038-65-4
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2 PLK3 (IC50s: 5 56 nM).
  • Inquiry Price
Size
QTY
BI 2536
T6173755038-02-9
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
  • Inquiry Price
Size
QTY
Onvansertib
NMS-P937, NMS-1286937
T62471034616-18-6
Onvansertib (NMS-1286937) is a PLK1 inhibitor (IC50=2 nM) with high selectivity and oral activity. Onvansertib has antitumor activity and inhibits tumor growth.
  • Inquiry Price
Size
QTY
GSK461364
GSK461364A
T6282929095-18-1
GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2 3.
  • Inquiry Price
Size
QTY
Wortmannin
SL-2052, KY-12420
T628319545-26-7
Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8 48 nM) that blocks autophagy.
  • Inquiry Price
Size
QTY
Poloxin
T16560321688-88-4
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor targeting the polo-box domain (IC50: appr 4.8 μM).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
TC-S 7005
T170081082739-92-1
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
SBE13 Hydrochloride
SBE 13 hydrochloride, SBE 13 HCl
T22711052532-15-6
SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2 3.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
HMN-176
T3643173529-10-7
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Rigosertib sodium
Rigosertib, Estybon, ON-01910
T5818592542-60-4
Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Poloxime
T1655917302-61-3
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
  • Inquiry Price
7-10 days
Size
QTY
Rigosertib
ON-01910
T16750592542-59-1
Rigosertib (ON-01910) is a selective, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor. As a selective anti-cancer agent, Rigosertib induces apoptosis by inhibiting the PI3 kinase Akt pathway, promotes histone H2AX phosphorylation, and induces G2 M arrest in the cell cycle.
  • Inquiry Price
Size
QTY
mps1-in-2
T18391228817-38-6
Mps1-IN-2 is a potent, selective, and ATP-competitive inhibitor of both Mps1 and Plk1.
  • Inquiry Price
7-10 days
Size
QTY
TTK/PLK1-IN-1
T2030641817791-70-0
TTK PLK1-IN-1 (Formula I) is an inhibitor of threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1), with IC50 values of 7 nM and 72 nM, respectively. It regulates the spindle assembly checkpoint (SAC) and exhibits antitumor activity against triple-negative breast cancer (TNBC).
  • Inquiry Price
Size
QTY
PLK1-IN-11
T20554873663-97-5
PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.
  • Inquiry Price
10-14 weeks
Size
QTY
Cyclapolin 9
T2270040533-25-3
Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.
  • Inquiry Price
6-8 weeks
Size
QTY