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PKD

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    33
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • PROTAC Products
    3
    TargetMol | PROTAC
  • Natural Products
    1
    TargetMol | Natural_Products
  • Recombinant Protein
    6
    TargetMol | Recombinant_Protein
  • Antibody Products
    8
    TargetMol | Antibody_Products
PKD-IN-1
T8957956121-30-5
PKD-IN-1 is an inhibitor of PKD.
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1-2 weeks
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N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine
T92561071135-06-2
N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine is a novel 2,6-naphthyridine identified by high throughput screen (HTS) as a dual protein kinase C D (PKC PKD) inhibitor[1].
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CID755673
T2458521937-07-5
CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.
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Mitapivat
PKR-IN-1
T42231260075-17-9
Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
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crt0066101 dihydrochloride
TQ01041883545-60-5
CRT0066101 dihydrochloride is an effective and selective PKD inhibitor (IC50s: 1, 2.5 and 2 nM for PKD1, 2, and 3).
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PKD-IN-1 dihydrochloride (956121-30-5 free base)
T8957L2308510-39-4
PKD-IN-1 dihydrochloride is an inhibitor of PKD.
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BPKDi
T251721201673-28-0
BPKDi is a potent and selective inhibitor of PKD (protein kinase D).
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6-8 weeks
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Mepyramine maleate
Pyrilamine maleate
T123259-33-6
Mepyramine maleate (Pyrilamine maleate) is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
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kb-NB77-78
T18081350622-33-1
kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).
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TargetMol | Inhibitor Sale
CID-797718
CID 797718
T1858370586-05-3
CID-797718 is a protein kinase D1 (PKD1) inhibitor.
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TargetMol | Inhibitor Sale
ARC 239 dihydrochloride
T2203355974-42-0
ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist with pKD values of 8.8, 6.7, and 6.4 at α2B, α2A, and α2D receptors respectively (pKD values are 8.8, 6.7, and 6.4 at α2B, α2A, and α2D receptors respectively).
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TargetMol | Inhibitor Sale
AQW051
AQ W051, VQW-765, AQW-051
T26646669770-29-0
AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attractive target for the treatment of cognitive impairments associated with neurological disorders, so VQW-051 is often used in studies of anxiety disorders and acute anxiety.
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6-8 weeks
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TargetMol | Inhibitor Sale
PROTAC EED degrader-1
T12553
PROTAC EED degrader-1, a PROTAC targeting EED (pKD = 9.02), is an inhibitor of polycomb repressive complex 2 (PRC2) with a pIC50 of 8.17.
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PROTAC EED degrader-2
T12554
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27) and an inhibitor of polycomb repressive complex 2 (PRC2) with a pIC50 of 8.11.
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GSK8814
T154431997369-78-4
GSK8814 is a selective and ATAD2 2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan). GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s: 7.3 and 4.6).
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10-14 weeks
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CID 2011756
CID2011756, CID-2011756
T1863638156-11-3
CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.
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(S,R,S)-AHPC-O-Ph-PEG1-NH2
VH032-O-Ph-PEG1-NH2
T186732361117-24-8
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is an E3 ligase ligand-linker conjugate that combines a VHL ligand for the E3 ubiquitin ligase with a PROTAC linker; it is used in PROTAC EED degrader-1, targeting EED with a potency (pKD) of 9.02[1].
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BSc5367
BSc 5367
T2013893029584-84-4
BSc5367 is a potent inhibitor of the structural domain of Nek1 kinase with an IC50=11.5 nM. Nek1 is a NIMA-associated protein kinase tightly linked to cell cycle regulation, DNA repair, and microtubule regulation. BSc5367 can be used in studies related to amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD), and several types of radiotherapy-resistant cancers.
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AV457
T2042852713387-11-0
AV457 is a potent and selective inhibitor of mTOR. It effectively suppresses cyst growth in polycystic kidney disease (PKD) organoids. AV457 reduces the protein expression of P-s6 and P-p70s6, but it does not decrease the protein expression of P-AKT.
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kb NB 142-70
T20621233533-04-4
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor with IC50 values of 28.3 nM, 58.7 nM, and 53.2 nM for PKD1, PKD2, and PKD3 respectively.
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1-NM-PP1
PP1 Analog II, 1 nM-PP1
T2153221244-14-0
1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
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CRT5
T217951034297-58-9
CRT5, a pyrazine benzamide, is a potent and selective PKD inhibitor. It inhibits VEGF-induced phosphorylation of three PKD substrates (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively), histone deacetylase 5, CREB (cAMP-response-element-binding protein), and HSP27 (heat-shock protein 27) at Ser82. Additionally, CRT5 decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis[1].
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6-8 weeks
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sdz 21009
T2334339731-05-0
β-adrenoceptor and 5-HT1A 1B receptor antagonist
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6-8 weeks
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RX821002
RX-821002,RX 821002
T28631102575-24-6
RX821002 is a potent and selective antagonist of α2-adrenoceptor with low affinity for imidazoline sites. RX821002 displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).
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6-8 weeks
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