pkd — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2458	CID755673		Serine/threonin kinase
	CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.		Serine/threonin kinase
T1863	CID 2011756	CID2011756,CID-2011756	Serine/threonin kinase
	CID 2011756 is an ATP-competitive and specific PKD1 inhibitor.		Serine/threonin kinase
T2062	Kb NB 142-70		Serine/threonin kinase
	kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).		Serine/threonin kinase
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
T4223	Mitapivat	PKR-IN-1	PKM
	Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.		PKM
TQ0104	CRT0066101 dihydrochloride		Serine/threonin kinase
	CRT0066101 dihydrochloride is an effective and selective PKD inhibitor (IC50s: 1, 2.5 and 2 nM for PKD1, 2, and 3).		Serine/threonin kinase
T25172	BPKDi
	BPKDi is a potent and selective inhibitor of PKD (protein kinase D).
T8957L	CRT0066101 dihydrochloride(956121-30-5 free base)		Serine/threonin kinase
	CRT0066101 dihydrochloride is an inhibitor of PKD.		Serine/threonin kinase
T9256	N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine		Serine/threonin kinase , PKC
	N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine is a novel 2,6-naphthyridine identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor[1].		Serine/threonin kinase , PKC
T22033	ARC 239 dihydrochloride		Norepinephrine
	ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).		Norepinephrine
T1858	CID-797718	CID 797718	Serine/threonin kinase
	CID-797718 is a protein kinase D1 (PKD1) inhibitor.		Serine/threonin kinase
T26646	AQW051	AQ W051,VQW-765,AQW-051	AChR
	AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attrac...		AChR
T3311	GSK6853		Epigenetic Reader Domain
	GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.		Epigenetic Reader Domain
T1808	Kb-NB77-78		Serine/threonin kinase
	kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).		Serine/threonin kinase
T2153	1-NM-PP1	PP1 Analog II,1 nM-PP1	Serine/threonin kinase , CDK , Src
	1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.		Serine/threonin kinase , CDK , Src
T1232	Mepyramine maleate	Pyrilamine maleate	Histamine Receptor
	Mepyramine maleate (Pyrilamine maleate) is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. I...		Histamine Receptor
T8957	CRT0066101		Serine/threonin kinase
	CRT0066101 is an inhibitor of PKD.		Serine/threonin kinase
T61163	Protein kinase D inhibitor 1
	Protein kinase D inhibitor 1 (compound 17m) is a potent pan-PKD inhibitor. It exhibits inhibitory activity in the low nanomolar range, with IC50 values ranging between 17 and 35 nM. By inhibiting protein kinase D, this c...
T28631	RX821002	RX-821002,RX 821002
	RX821002 is a potent and selective antagonist of α2-adrenoceptor with low affinity for imidazoline sites. RX821002 displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).
T75861	ANQ-11125 TFA
	ANQ-11125 TFA is a potent, selective motilin antagonist, exhibiting a pKd of 8.24. It effectively inhibits motilide-induced contractions in rabbit models, as demonstrated in vitro [1] [2].