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Search Results for " huntington's disease "

20

Compounds

Cat No. Product Name Synonyms Targets
T8452 Dantrolene Others
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
T9998 MIND4-19 Sirtuin
MIND4-19 is an inhibitor of SIRT2 with antitumor activity.
T6111 Selisistat EX-527,SEN0014196 Sirtuin
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea.
T26878 BN-82451 2HCl BN-82451B 2HCl,BN 82451B 2HCl COX
BN-82451 2HCl is a dual inhibitor of COX-1 and COX-2 and can be used to study Huntington's chorea and Parkinson's disease.
T22595 B2 Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline Others , Sirtuin
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
T9159 PBT-1033 PB 1033,PBT1033,PBT-2,PBT 2,PBT2 Others
PBT-1033 (PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
T62839 Dalzanemdor SAGE-718 NMDAR , iGluR
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
T38605 NCT-504 Others
NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease.
T23331 SC 51089 SC 51089 free base Prostaglandin Receptor
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's...
T61859 MK-28 Antiviral , PERK
MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.
T2075 Pyrazolo[1,5-a]pyrimidine 4h Others
Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chore...
T9340 1-phenyl-3,4-dihydroisochinoline 3,4-Dihydro-1-phenylisoquinoline Others
1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a p...
T13133 Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ Monoamine Transporter
Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetraben...
T40652 Meclizine Meclozine Histamine Receptor
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ...
T28363 PF-02545920 Others
PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease.
T33895 PBT-1033 hydrochloride PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033 Others
PBT-1033 hydrochloride is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
T39480 Lexanersen WVE-120102,Lexanersen Others
Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research.
T40843 1-(Anilinocarbonyl)proline Others
1-(Anilinocarbonyl)proline is a compound utilized for identifying dual-action probes within a cell model of Huntington's disease.
T69441 NSC66098 Others
NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein.
T71969 Remacemide Others
Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease.
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TargetMol