hmt — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6364	Desfesoterodine	5-HMT,(R)-5-Hydroxymethyl Tolterodine,PNU-200577,5-HM,5-hydroxymethyl Tolterodine	AChR
	Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.		AChR
T8548	Metoprine		Histone Methyltransferase , Antifolate , Histamine Receptor
	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.		Histone Methyltransferase , Antifolate , Histamine Receptor
T9419	Fesoterodine	(R) Fesoterodine	AChR
	Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB).		AChR
T1475	Fesoterodine fumarate	Toviaz,SPM 907	AChR
	Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo...		AChR
T12902	SHMT-IN-1		Others
	SHMT-IN-1 is a potent plasmodial serine hydroxymethyltransferase (SHMT) inhibitor with antitumor activity.		Others
T62512	IHMT-MST1-58		Hippo pathway
	IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.		Hippo pathway
T60196	IHMT-PI3Kδ-372 S-isomer		PI3K
	IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can ...		PI3K
T62404	SHMT-IN-2		Others
	SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell ly...		Others
T35530	IHMT-PI3Kδ-372	IHMT-PI3Kδ-372	PI3K
	IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.		PI3K
T11167	EHMT2-IN-2		Others
	EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.		Others
T11166	EHMT2-IN-1		Others
	EHMT2-IN-1 is a potent EHMT inhibitor, . Used in the research of blood disorder or cancer.with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.		Others
TP1460	NH2-KLGADTDGEQDQHMTYGGQ-COOH
	NH2-QGGYTMHQDQEGDTDAGLK-COOH is a synthetic peptide chain consisting of a primary amine group attached to lysine and a carboxyl group attached to glutamine.
T79780	IHMT-EZH2-426		Histone Methyltransferase
	IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effective...		Histone Methyltransferase
T78836	IHMT-PI3K-455		PI3K
	IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for PI3Kδ. This compound inhibits AKT phosphorylation and promotes...		PI3K
T78758	IHMT-IDH1-053		Isocitrate Dehydrogenase (IDH)
	IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-...		Isocitrate Dehydrogenase (IDH)
T63076	IHMT-TRK-284
	IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor that acts on TRKA (IC50: 10.5 nM), TRKB (IC50: 0.7 nM), and TRKC (IC50: 2.6 nM). IHMT-TRK-284 exhibits good selectivity in the kinase gro...
T8768	MM-102 TFA	HMTase Inhibitor IX TFA	Histone Methyltransferase
	MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WD...		Histone Methyltransferase
T67947	WDR5-0102		Histone Methyltransferase
	WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT...		Histone Methyltransferase
T2352	AMI-1		Histone Methyltransferase
	AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).		Histone Methyltransferase
T6803	Chaetocin		Histone Methyltransferase , Antibacterial , Antibiotic
	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.		Histone Methyltransferase , Antibacterial , Antibiotic