dyrk1a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62414	Dyrk1A-IN-1
	Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.
T60867	Dyrk1A-IN-4
	Dyrk1A-IN-4 (compound 48) is a potent and orally active DYRK1A and DYRK2 dual inhibitor with anticancer effects. The IC50 values of Dyrk1A-IN-4 for DYRK1A and DYRK2 are 2 nM and 6 nM, respectively [1].
T63440	Dyrk1A-IN-2
	Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.
T60824	Dyrk1A-IN-3
	Dyrk1A-IN-3 (Compound 8b) is a highly selective inhibitor of dual-specificity tyrosine-regulated kinase 1A (DYRK1A). Dyrk1A-IN-3 has high binding affinity of DYRK1A with an IC 50 of 76 nM. Dyrk1A-IN-3 can be used in neur...
T61739	Dyrk1A-IN-5
	Dyrk1A-IN-5 (compound 5j) is a highly potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It dose-dependently diminishes the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Moreover, Dyrk1A-...
T62043	Dyrk1A/B-IN-1
	Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable inhibitor of DYRK1A and DYRK1B. Dyrk1A/B-IN-1 inhibits DYRK1A and DYRK1B with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectiv...
T62226	Dyrk1A/α-synuclein-IN-2
	Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM). Dyrk1A/α-synuclein-IN-2 has a high predictive CNS permeability and neuroprotective...
T62096	Dyrk1A/α-synuclein-IN-1
	Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM). CNS permeability and neuroprotective activity.
T14980	CLK-IN-T3		DYRK , CDK
	CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.		DYRK , CDK
T15579	INDY	1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one	DYRK
	INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.		DYRK
T26632	AnnH31		MAO , DYRK
	AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the involvement of DYRK1A in cellular phosphorylation.		MAO , DYRK
T11447	GNF4877		GSK-3 , DYRK
	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.		GSK-3 , DYRK
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T28218	NU6102	NU-6102,NU 6102	CDK
	NU6102 is a selective and potent ATP-competitive CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK2/cyclinA3, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.		CDK
T15204	EHT 1610	EHT 5372	GSK-3 , NF-κB , Tyrosinase , DYRK , CDK
	EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, regulating cell cycle and inducing cell apoptosis...		GSK-3 , NF-κB , Tyrosinase , DYRK , CDK
T10827	CK2/ERK8-IN-1	TMCB	Apoptosis , ERK , Casein Kinase , Pim , DYRK
	CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25...		Apoptosis , ERK , Casein Kinase , Pim , DYRK
T21915	TBCA	Casein Kinase II Inhibitor III, TBCA	Casein Kinase
	TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.		Casein Kinase
T61360	ARN25068		GSK-3 , DYRK , Microtubule Associated , Src
	ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1].		GSK-3 , DYRK , Microtubule Associated , Src
T6257	AZ191		DYRK
	AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.		DYRK
T72039	CLK1-IN-3		DYRK , CDK , Autophagy
	Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly effective inhibition of Clk2 and Clk4, with IC50 values of 4...		DYRK , CDK , Autophagy