akt3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T74982	Akt3 degrader 1
	Akt3 Degrader 1 (compound 12l), a selective Akt3 degrader, effectively overcomes Osimertinib-induced resistance in H1975OR NSCLC cells. Besides its role in overcoming drug resistance, it exhibits anti-proliferative prope...
T3467	Miransertib	ARQ-092,AKT inhibitor 2	Akt , Parasite
	Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.		Akt , Parasite
T11928	M2698	MSC2363318A	Akt , mTOR
	M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.		Akt , mTOR
T15374	Ipatasertib dihydrochloride	GDC-0068 dihydrochloride,RG-7440 dihydrochloride	Akt , PKA
	Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively).		Akt , PKA
T7885	Afuresertib hydrochloride		ROCK , Akt , PKC
	Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)		ROCK , Akt , PKC
T14072	A-443654		ERK , VEGFR , GSK-3 , FLT , Casein Kinase , MAPK , Akt , PKA , Chk , CDK , Src , PKC , S6 Kinase
	A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T38846	Vevorisertib trihydrochloride	ARQ 751 trihydrochloride	Akt
	Vevorisertib trihydrochloride (ARQ 751 trihydrochloride) is a selective and potent inhibitor of pan-AKT and AKT1-E17K mutations, inhibiting AKT1, AKT2 and AKT3. Vevorisertib trihydrochloride is used in the study of hepat...		Akt
T1952	MK-2206 dihydrochloride	MK-2206 2HCl	Apoptosis , Akt , Autophagy
	MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor a...		Apoptosis , Akt , Autophagy
T39733	Hu7691 free base		Akt
	Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces ...		Akt
T1920	Capivasertib	AZD5363	Akt , PKA , mTOR , Autophagy
	Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer.		Akt , PKA , mTOR , Autophagy
T3346	AKT inhibitor VIII	AKTi-1/2	Apoptosis , Akt
	AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.		Apoptosis , Akt
T6252	Ipatasertib	GDC-0068,RG7440	Akt
	Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.		Akt
T1911	Afuresertib	GSK2110183C,GSK2110183	ROCK , Akt , PKC
	Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.		ROCK , Akt , PKC
T6849	Uprosertib	GSK2141795,GSK795	Akt
	Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.		Akt
T6304	AT7867		Akt , PKA , S6 Kinase
	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.		Akt , PKA , S6 Kinase
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T15428	Uprosertib hydrochloride	GSK2141795 (hydrochloride)	Others
	Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).		Others
T39930	MS98
	MS98 is a highly effective and specific PROTAC AKT degrader compound that effectively targets and depletes total AKT (T-AKT) within cells, exhibiting a DC 50 value of 78 nM. This compound readily binds to AKT1, AKT2, and...
T11664	INY-03-041		Others
	INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. This compound consists of the ATP-competitive AKT inhibitor G...		Others