BODIPY Series

BODIPY 581 591 C11 is a fluorescent radioactive probe used to indicate lipid peroxidation and antioxidant efficacy in model membrane systems and living cells.

BODIPY-Cholesterol (TF-Chol) is a cholesterol analog with a fluorescent BODIPY motif and cellular permeability, and is a novel BODIPY cholesterol probe.BODIPY-Cholesterol can be used to study intracellular sterol uptake and interorganelle sterol flux.

BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with binding affinities of Ki: 14.5 nM for α1a-AR and Ki: 43.3 nM for α1b-AR, used to study subcellular localization differences in α1-adrenoceptor subtypes.

Py-BODIPY-NHS ester is a small molecular dye with strong UV absorption that can be used to label living cells and immobilise cells.

BODIPY 505 515 is a lipophilic fluorescent probe that localises to intracellular liposomes and has been used to label lipid droplets.BODIPY 505 515 has been used in electron microscopy, epifluorescence microscopy, confocal microscopy, and flow cytometry applications for various algal species.

BODIPY-FL (BDP FL acid) is a broad-spectrum and effective fluorescent dye that can be used to label probes or primers and is a compound for the quantitative detection of specific DNA RNA based on fluorescence bursts.BODIPY-FL-labelled monoterpenes can be used to detect Gram-positive and Gram-negative bacteria as characteristic and pathogenic fungi.

8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY can be used in photodynamic therapy.

8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY is a novel BODIPY fluorescent dye for the treatment of cytotoxicity.

BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of VHL ligands. BODIPY FL VH032 consists of a derivative of von Hippel-Lindau (VHL) ligand VH 032 and a fluorophore BODIPY FL(with excitation peak at 504 nm and emission peak at 520 nm), joined by a polyethylene glycol (PEG) 4 linker. The BODIPY FL VH032 VHL TR-FRET signal is stable through the 90 - 300 min incubation time, and theTR-FRET binding assay is sensitive, selective and resistant to assay interference. BODIPY FL VH032 also exhibits high VHL affinity in a fluorescence polarization (FP) assay. Excitation maximum ~ 504 nm; emission maximum ~ 520 nm.

BODIPY-TS (also known as Thiol-green 2) is a highly efficient thiol-specific turn-on probe with a fast response. It incorporates a thiosulfonate scaffold as its thiol recognition unit. BODIPY-TS displays excellent selectivity, low detection limit, and quantitative reactivity towards thiols. Moreover, it exhibits low toxicity. Notably, BODIPY-TS exhibits excitation at 490 nm and emission at 515 nm.

BDP 581 591 NHS ester, a borondipyrromethene dye (Ex=585 nm, Em=594 nm), exhibits a relatively long fluorescence lifetime and significant two-photon excitation cross-section. This compound is applicable in fluorescence polarization analysis, interacts with reactive oxygen species (ROS) to modify fluorescence, and, as an NHS ester derivative, binds to the primary and secondary amine groups of proteins, peptides, and various molecules. Storage instructions highlight the importance of protecting it from light.

BDP 630 650 amine is a far-red luminescent boron dipyridyl fluorophore (λex=630 nm, λem=650 nm) used for labeling various electrophilic compounds.

STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric approach to accurately determine the reactivity of radical-trapping antioxidants. J. Org. Chem. 81(3), 737-744 (2016).2. Shah, R., Shchepinov, M.S., and Pratt, D.A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4(3), 387-396 (2018).3. Chauvin, J.-P.R., Haidasz, E.A., Griesser, M., et al. Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution. Chem. Sci. 7(10), 6347-6356 (2016). STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3 References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric approach to accurately determine the reactivity of radical-trapping antioxidants. J. Org. Chem. 81(3), 737-744 (2016).2. Shah, R., Shchepinov, M.S., and Pratt, D.A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4(3), 387-396 (2018).3. Chauvin, J.-P.R., Haidasz, E.A., Griesser, M., et al. Polysulfide-1-oxides react with peroxyl radicals as quickly as hindered phenolic antioxidants and do so by a surprising concerted homolytic substitution. Chem. Sci. 7(10), 6347-6356 (2016).

BODIPY 576 589 is a long-wavelength biological labeling dye.

meso-CF3-BODIPY 2, also known as CF3-substituted Tetramethyl BODIPY, is a fluorescent dye that has an absorption wavelength (λ abs ) of 553 nm and an emission wavelength (λ em ) of 622 nm. This compound is commonly utilized as a labeling reagent and in photodynamic therapy.

BODIPY FL Thapsigargin, a potent green fluorescent dye, effectively inhibits intracellular SERCA-type Ca 2+ pumps localized in the sarcoplasmic endoplasmic reticulum. It is utilized to investigate thapsigargin binding sites in live cells [1] [2]. For storage, it is crucial to protect this compound from light.

Bodipy TMR-X muscimol, a Bodipy-labeled muscimol (Ex=543 nm, Em=572 nm), acts as a GABAA agonist. This compound is utilized for visualizing the distribution of reversible brain inactivations [1].

PYBG-BODIPY, a fluorochrome dye, specifically and efficiently labels genetically encoded SNAP-tags in live cells, serving its role as a targeted marker.