BODIPY Series

BODIPY 581/591 C11 is a fluorescent radioactive probe used to indicate lipid peroxidation and antioxidant efficacy in model membrane systems and living cells.

BODIPY 493/503 (Pyrromethene 546) is a lipophilic fluorescent probe with Ex/Em of 493/503 nm. BODIPY 493/503 localizes to polar lipids and can be used to label cellular neutral lipid contents and for live and fixed cell applications.

Py-BODIPY-NHS ester is a small molecular dye with strong UV absorption that can be used to label living cells and immobilise cells.

CycLuc1, a brain-penetrant luciferase substrate, may be a superior BLI substrate compared to D-luciferin for monitoring tumor growth in intracranial GBM (glioblastoma) xenografts.

BODIPY 505 515 is a lipophilic fluorescent probe that localises to intracellular liposomes and has been used to label lipid droplets.BODIPY 505 515 has been used in electron microscopy, epifluorescence microscopy, confocal microscopy, and flow cytometry applications for various algal species.

BODIPY 630/650X is a fluorescently labeled conjugate of the adenosine receptor ligand N-ethylcarboxamido-adenosine (NECA), which exhibits distinct excitation and emission maxima at approximately 630 nanometers and 650 nanometers, respectively, making it a valuable tool for fluorescence-based assays and imaging studies targeting adenosine receptor activity and distribution.

BODIPY-FL (BDP FL acid) is a broad-spectrum and effective fluorescent dye that can be used to label probes or primers and is a compound for the quantitative detection of specific DNA/RNA based on fluorescence bursts.BODIPY-FL-labelled monoterpenes can be used to detect Gram-positive and Gram-negative bacteria as characteristic and pathogenic fungi.

BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with binding affinities of Ki: 14.5 nM for α1a-AR and Ki: 43.3 nM for α1b-AR, used to study subcellular localization differences in α1-adrenoceptor subtypes.

8-Phenyl-BODIPY 505 515 are phenyl-substituted BODIPY derivatives, thereby altering the phosphorescent properties of BODIPY, triplet and monoclinic oxygen generation, and can be used as fluorescent probes.

8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY is a novel BODIPY fluorescent dye for the treatment of cytotoxicity.

8-Phenyl-2,6-dibromo-1,3,5,7-tetramethyl BODIPY can be used in photodynamic therapy.

BODIPY-Cholesterol (TF-Chol) is a cholesterol analog with a fluorescent BODIPY motif and cellular permeability, and is a novel BODIPY cholesterol probe.BODIPY-Cholesterol can be used to study intracellular sterol uptake and interorganelle sterol flux.

8-Chloro-1,3,5,7-tetramethyl BODIPY is a fluorescent dye featuring a boron-dipyrromethene core. This compound has methyl and chlorine atom substituents at specific positions on the pyrrole rings. It exhibits a high fluorescence quantum yield and distinct absorption and emission wavelengths. Ex Em(nm)=500 515.

BODIPY 558 568 carboxylic acid exhibits high quantum yield and extinction coefficient, resulting in bright yellow-red fluorescence. The excitation emission wavelengths are 558 568 nm.

BODIPY-TS (also known as Thiol-green 2) is a highly efficient thiol-specific turn-on probe with a fast response. It incorporates a thiosulfonate scaffold as its thiol recognition unit. BODIPY-TS displays excellent selectivity, low detection limit, and quantitative reactivity towards thiols. Moreover, it exhibits low toxicity. Notably, BODIPY-TS exhibits excitation at 490 nm and emission at 515 nm.

Compound 1, known as Caffeine Orange, serves as a highly selective aqueous-phase fluorescence turn-on sensor specifically for caffeine. When exposed to 532 nm green excitation light, this compound causes caffeinated coffee to turn orange. Caffeine Orange boasts impressive photophysical properties, including a high extinction coefficient, excellent light stability, and a narrow emission bandwidth, making it valuable in the development of caffeine detection devices [1].

BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of VHL ligands. BODIPY FL VH032 consists of a derivative of von Hippel-Lindau (VHL) ligand VH 032 and a fluorophore BODIPY FL(with excitation peak at 504 nm and emission peak at 520 nm), joined by a polyethylene glycol (PEG) 4 linker. The BODIPY FL VH032 VHL TR-FRET signal is stable through the 90 - 300 min incubation time, and theTR-FRET binding assay is sensitive, selective and resistant to assay interference. BODIPY FL VH032 also exhibits high VHL affinity in a fluorescence polarization (FP) assay. Excitation maximum ~ 504 nm; emission maximum ~ 520 nm.

BODIPY-FL staurosporine (Compound 8a) is a fluorescent probe based on staurosporine, exhibiting high specificity for tyrosine kinases (TK) and tyrosine kinase-like (TKL) families. This compound holds the potential to develop binding assays for kinases that are not recommended for use with kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3.

BODIPY 505 515-8-C3-COOH, a green fluorescing derivative, serves as a fluorescent dye, particularly useful in imaging lipid droplets in nannochloropsis. It is also applicable in flow cytometric high-throughput screening and cell sorting research [1].

Bodipy TR alkyne, a boron dipyrromethene fluorophore for the ROX (Texas Red) channel, is versatile for applications in microscopy, fluorescence polarization measurements, and other uses. This derivative serves as a terminal alkyne in copper-catalyzed click chemistry.

BDP 581 591 amine hydrochloride, a BODIPY dye linker, is a universal, photostable fluorophore. The amine group addition enables the compound to react with carboxylic acids, activated NHS esters, and other carbonyl groups [1].

BODIPY FL-X,SE, a green fluorescent dye designed for amine labeling, exhibits a high fluorescence quantum yield with minimal sensitivity to pH variations. It serves as a viable alternative to FAM, Cy2, or FITC. The dye's absorption and emission wavelengths are 504 nm (λ abs) and 510 nm (λ em), respectively.

ODIPY FL EDA free base, an amine-based green fluorescent probe, possesses an R-NH2 group able to undergo coupling with aldehydes or ketones, forming reversible Schiff base adducts. These intermediates can be subsequently converted into stable amine derivatives through reduction with agents like sodium borohydride or sodium cyanoborohydride. The compound is applicable in the detection of both modified and normal deoxynucleotides, as well as in illustrating DNA damage and genomic DNA methylation.

Pyrromethene 597, a BODIPY laser dye, exhibits a wide tuning range of lasing wavelengths along with high photostability, and can serve as a thermal probe [1] [2].