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Conjugation and labelingThiol
Thiol dyes are a class of chemical reagents that react specifically with thiol groups (-SH) and are often used to modify and label thiol-containing biomolecules, such as proteins or peptides. By forming stable covalent bonds, they can impart fluorescence, colorimetric or other functionalities to target molecules. They are widely used in the fields of bioimaging, protein analysis and drug development.
Bromobimane
T1892971418-44-5
Bromobimane (Monobromobimane) is a non-fluorescent substance, but reacts with thiols to produce a fluorescent product.Bromobimane is used as a probe, often in clinical medicine, to test for sulfide levels in blood.
- $49
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Fluorescein-5-maleimide
T1899175350-46-8
Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent thiol-reactive dye (excitation: 494 nm, emission: 519 nm).
- $32
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TPE-MI
T742471245606-71-6
TPE-MI (Tetraphenylethene maleimide) is an aggregation-induced luminescent agent that stains living cells, can be used to capture cysteines in exposed unfolded proteins, and detects protein damage after dihydroartemisinin studies of malaria parasites.
- $52
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5-IAF
T1405263368-54-7
5-IAF is a fluorescein derivative of indoleacetamide, a fluorescent probe that can be used to label proteins and others containing free thiols (cysteine side chains). 5-IAF can label the catalytic (alpha) subunit of dog kidney Na,K-ATPase.
- $31
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NBD-Cl
T1903010199-89-0
NBD-Cl (NBD chloride) is a nonfluorescent compound that becomes highly fluorescent after reaction with amino or thiol groups.
- $29
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BODIPY-TS
T392341808174-52-8
BODIPY-TS (also known as Thiol-green 2) is a highly efficient thiol-specific turn-on probe with a fast response. It incorporates a thiosulfonate scaffold as its thiol recognition unit. BODIPY-TS displays excellent selectivity, low detection limit, and quantitative reactivity towards thiols. Moreover, it exhibits low toxicity. Notably, BODIPY-TS exhibits excitation at 490 nm and emission at 515 nm.
- $5,819
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NIR dye-1
T190371392488-07-1
NIR dye-1 is a near-infrared (NIR) fluorescent dye which has absorption and emission in the NIR region while retaining an optically tunable hydroxyl group.
- $1,520
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6-Iodoacetamidofluorescein
T4084773264-12-7
6-Iodoacetamidofluorescein is a sulphhydryl-specific fluorescent dye utilized for selective labeling of -SH groups present in nuclear matrix polypeptides and proteins.
- $1,520
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Acrylodan
T4097886636-92-2
Acrylodan, when subjected to thiol reactions, exhibits sensitivity to the dipolarity and dynamics of its surrounding binding pocket, specifically those surrounding Cys 34.
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SEluc-2
T400822421112-19-6
SEluc-2, a bioluminescent probe derived from firefly luciferin, is designed for the sensitive and selective detection of thiols in living cells.
- $913
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MTSEA-Fluorescein
T753681356019-48-1
MTSEA-Fluorescein is a fluorescent probe utilized in ion channel research [1]. Store protected from light.
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Tetramethylrhodamine-5-iodoacetamide
T17060114458-99-0
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye used to non-specifically label proteins through cysteine residues and to covalently label DNA fragments [1].
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