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GPCR/G Protein

Melanin-concentrating Hormone Receptor (MCHR)

(10)

Melanocortin Receptor

Neuropeptide Y Receptor

Prostaglandin Receptor

(181)

Protease-activated Receptor

TSH Receptor

The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the Gs protein.

Filter Signaling PathwaysGPCR/G ProteinTSH Receptor

VA-K-14 hydrochloride
T290871171341-19-7In house
VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
- $54
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ML-109
T120731186649-91-1
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
- $31
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Cited
D3-βArr
T5383662164-09-2
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
- $40
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TSHR antagonist S37
T132161217616-61-9
TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
- $62
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Org41841
T16403301847-37-0
Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism.
- $199
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ML224
T161061338824-21-7
ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.
- $52
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Teprotumumab
T767271036734-93-6
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab reduces TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used in the study of thyroid-associated eye diseases.
- $198
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NCGC00229600
T121921338824-20-6
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies.
- $100
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