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Metabolism PKM

PKM

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.
Cat No. product name
T12499 PKR-IN-2 PKR-IN-2 is a activator of pyruvate kinase (PKR).
T8363 DL-Serine DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
T7214 ML265 ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in ...
T4170 PKM2 inhibitor PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T1125 (+)-Shikonin Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pat...
T4223 Mitapivat Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T6816 DASA58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
PKR-IN-2
T12499CAS 1628428-01-2
PKR-IN-2 is a activator of pyruvate kinase (PKR).
DL-Serine
T8363CAS 302-84-1
DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
ML265
T7214CAS 1221186-53-3
ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in ...
PKM2 inhibitor
T4170CAS 94164-88-2
PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
(+)-Shikonin
T1125CAS 517-89-5
Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pat...
Mitapivat
T4223CAS 1260075-17-9
Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
DASA58
T6816CAS 1203494-49-8
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.