T12672 |
(Rac)-Nedisertib
|
1637542-34-7
|
98%
|
|
(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
|
T5166 |
Leniolisib
|
1354690-24-6
|
98%
|
|
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
|
T2433 |
NU 7026
|
154447-35-5
|
98%
|
|
NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
|
T15789 |
LTURM34
|
1879887-96-3
|
98%
|
|
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
|
T6612 |
NU6027
|
220036-08-8
|
98%
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
|
T2616 |
PIK-93
|
593960-11-3
|
98%
|
|
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
|
T2685 |
KU-55933
|
587871-26-9
|
98%
|
|
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
|
T6087 |
AZD 6482
|
1173900-33-8
|
98%
|
|
AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
|
T3586 |
Compound 401
|
168425-64-7
|
98%
|
|
Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
|
T2008 |
LY294002
|
154447-36-6
|
98%
|
|
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
|
T6283 |
Wortmannin
|
19545-26-7
|
98%
|
|
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
|
T11381 |
Pictilisib dimethanesulfonate
|
957054-33-0
|
98%
|
|
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
|
T6883 |
Samotolisib
|
1386874-06-1
|
98%
|
|
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
|
T13448 |
(R)-(-)-Rolipram
|
85416-75-7
|
98%
|
|
(R)-(-)-Rolipram is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
|
T2084 |
ETP-46464
|
1345675-02-6
|
98%
|
|
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
|
T6100 |
Torin 2
|
1223001-51-1
|
98%
|
|
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
|
TQ0031 |
Nedisertib
|
1637542-33-6
|
98%
|
|
Nedisertib (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM).
|
T2377 |
Pilaralisib analogue
|
956958-53-5
|
98%
|
|
XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
|
T4339 |
YU238259
|
1943733-16-1
|
98%
|
|
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
|
T3351 |
Onatasertib
|
1228013-30-6
|
98%
|
|
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
|