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DNA-PK

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase consisting of a catalytic subunit (DNA-PKcs) and a Ku heterodimer that is made up of the Ku70 and Ku80 subunits. DNA-PK was accidentally discovered after researchers studying translation found that double-stranded DNA (dsDNA) contaminated their preparations, leading to the phosphorylation of specific proteins.
Cat. No. Product name CAS No. Purity Chemical Structure
T12672 (Rac)-Nedisertib 1637542-34-7 98%
(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
T5166 Leniolisib 1354690-24-6 98%
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
T2433 NU 7026 154447-35-5 98%
NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
T15789 LTURM34 1879887-96-3 98%
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
T6612 NU6027 220036-08-8 98%
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
T2616 PIK-93 593960-11-3 98%
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T2685 KU-55933 587871-26-9 98%
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T6087 AZD 6482 1173900-33-8 98%
AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
T3586 Compound 401 168425-64-7 98%
Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
T2008 LY294002 154447-36-6 98%
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
T6283 Wortmannin 19545-26-7 98%
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
T11381 Pictilisib dimethanesulfonate 957054-33-0 98%
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
T6883 Samotolisib 1386874-06-1 98%
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
T13448 (R)-(-)-Rolipram 85416-75-7 98%
(R)-(-)-Rolipram is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
T2084 ETP-46464 1345675-02-6 98%
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T6100 Torin 2 1223001-51-1 98%
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
TQ0031 Nedisertib 1637542-33-6 98%
Nedisertib (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM).
T2377 Pilaralisib analogue 956958-53-5 98%
XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T4339 YU238259 1943733-16-1 98%
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
T3351 Onatasertib 1228013-30-6 98%
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
(Rac)-Nedisertib
T12672
(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
Leniolisib
T5166
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
NU 7026
T2433
NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
LTURM34
T15789
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
NU6027
T6612
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
PIK-93
T2616
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
KU-55933
T2685
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
AZD 6482
T6087
AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
Compound 401
T3586
Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
LY294002
T2008
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
Wortmannin
T6283
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
Pictilisib dimethanesulfonate
T11381
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
Samotolisib
T6883
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
(R)-(-)-Rolipram
T13448
(R)-(-)-Rolipram is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
ETP-46464
T2084
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
Torin 2
T6100
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
Nedisertib
TQ0031
Nedisertib (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM).
Pilaralisib analogue
T2377
XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
YU238259
T4339
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
Onatasertib
T3351
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
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