DNA-PK

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase consisting of a catalytic subunit (DNA-PKcs) and a Ku heterodimer that is made up of the Ku70 and Ku80 subunits. DNA-PK was accidentally discovered after researchers studying translation found that double-stranded DNA (dsDNA) contaminated their preparations, leading to the phosphorylation of specific proteins.

Cat. No.	Product name	CAS No.	Purity
T12672	(Rac)-Nedisertib	1637542-34-7	98%
T12672	(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
T5166	Leniolisib	1354690-24-6	98%
T5166	Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
T2433	NU 7026	154447-35-5	98%
T2433	NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
T15789	LTURM34	1879887-96-3	98%
T15789	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
T6612	NU6027	220036-08-8	98%
T6612	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
T2616	PIK-93	593960-11-3	98%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T2685	KU-55933	587871-26-9	98%
T2685	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T6087	AZD 6482	1173900-33-8	98%
T6087	AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
T3586	Compound 401	168425-64-7	98%
T3586	Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
T2008	LY294002	154447-36-6	98%
T2008	LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
T6283	Wortmannin	19545-26-7	98%
T6283	Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
T11381	Pictilisib dimethanesulfonate	957054-33-0	98%
T11381	Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
T6883	Samotolisib	1386874-06-1	98%
T6883	LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
T13448	(R)-(-)-Rolipram	85416-75-7	98%
T13448	(R)-(-)-Rolipram is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
T2084	ETP-46464	1345675-02-6	98%
T2084	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T6100	Torin 2	1223001-51-1	98%
T6100	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic propert...
TQ0031	Nedisertib	1637542-33-6	98%
TQ0031	Nedisertib (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM).
T2377	Pilaralisib analogue	956958-53-5	98%
T2377	XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T4339	YU238259	1943733-16-1	98%
T4339	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
T3351	Onatasertib	1228013-30-6	98%
T3351	CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...