AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat. No.	Product name	CAS No.	Purity
T16113	ML753286	1699720-89-2	98%
T16113	ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
T10312	Ampkinone	1233082-79-5	98%
T10312	Ampkinone is an indirect AMPK activator.
T13371	YM-53601 free base	182959-28-0	98%
T13371	YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
TN1670	Ganodermanondiol	107900-76-5	98%
TN1670	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TN5013	Shizukaol D	142279-42-3	98%
TN5013	Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be...
TL0014	Pinusolide	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T10105	3α-Hydroxymogrol	1343402-73-2	98%
T10105	3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
TN1868	Ligupurpuroside A	147396-01-8	98%
TN1868	Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
T16166	N-[(4-Aminophenyl)methyl]adenosine	95523-13-0	98%
T16166	N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase).
TN3042	4-Hydroxycinnamamide	194940-15-3	98%
TN3042	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN4382	Kazinol A	99624-28-9	98%
TN4382	Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
TN1140	Onjisaponin B	35906-36-6	98%
TN1140	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-sy...
TN1870	Ligupurpuroside C	1194056-33-1	98%
TN1870	Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
T22460	XMD-17-51	1628614-50-5	98%
T22460	XMD-17-51 is a potent and highly selective NUAK1 inhibitor.
T11570	HL271	1422365-52-3	98%
T11570	HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
T14149	AICAR phosphate	681006-28-0	98%
T14149	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinf...
TN2179	Saponarin	20310-89-8	98%
TN2179	Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T41162	ZLN 024 hydrochloride	1883548-91-1	98%
T41162	ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
T6129	GSK-1070916	942918-07-2	98%
T6129	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
T13173	TMPA	1258275-73-8	98%
T13173	TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.