T13371 |
YM-53601 free base
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YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
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T5552 |
Methyl cinnamate
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Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
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TN1731 |
Hernandezine
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Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
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T0800 |
Danthron
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Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
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T1977 |
Dorsomorphin
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Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
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T3220 |
Euphorbiasteroid
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Euphorbiasteroid (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
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T13265 |
Urolithin B
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Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhance...
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T16099 |
MK8722
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MK8722 is an effective and systemic activator of pan-AMPK.
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T13411 |
ZLN024
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ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, ...
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T2750 |
Ginkgolide C
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Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
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TN1670 |
Ganodermanondiol
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Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
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TL0014 |
Pinusolide
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Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
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T3889 |
Platycodin D
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Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
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T7955 |
EB-3D
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EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
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TN6751 |
1-HEXACOSANOL
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Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
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T8740 |
COH-SR4
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SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inh...
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T9191 |
XMD-17-51 Trifluoroacetate
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XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.
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T0853L |
Adenosine 5'-monophosphate monohydrate
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Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
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T8929 |
BC1618
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BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
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TN1990 |
Norathyriol
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Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
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T6854 |
GSK621
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GSK621 is a specific and potent AMPK activator.
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T19500 |
Palmitelaidic Acid
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Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
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T2374 |
HTH-01-015
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HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
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T2133 |
Adenosine monophosphate
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Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
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T3405 |
[6]-Gingerol
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6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
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TQ0028 |
EX229
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EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
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T1020 |
Doxorubicin hydrochloride
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Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
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T16113 |
ML753286
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ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
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T11947 |
MARK4 inhibitor 1
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MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
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T1453 |
Phenformin hydrochloride
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Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
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T7362 |
O-304
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O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
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T6285 |
GSK-690693
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GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
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TN1100 |
Nepodin
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Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
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T2854 |
Phillyrin
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Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the express...
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T20029 |
Buformin hydrochloride
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Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointe...
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T6129 |
GSK-1070916
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GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
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T7327 |
7-Methoxyisoflavone
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7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
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T9219 |
WH-4-025
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WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
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T3863 |
Chikusetsusaponin IVa
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Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a...
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TN1440 |
Beta-Hydroxyisovalerylshikonin
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Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
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T2468 |
A-769662
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A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
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T5993 |
ARN-3236
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ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
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T2978 |
Mogroside V
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Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
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TN1836 |
Kudinoside D
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Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
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T2746 |
Sophocarpine monohydrate
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Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
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T3S0195 |
Nootkatone
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1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
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T10312 |
Ampkinone
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Ampkinone is an indirect AMPK activator.
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TN1499 |
Cimiracemoside C
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Cimiracemoside C is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.
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T5187 |
MK-3903
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MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
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T1477 |
AICAR
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Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...
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