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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
Cat No. product name
T13371 YM-53601 free base YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
T5552 Methyl cinnamate Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
TN1731 Hernandezine Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
T0800 Danthron Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T1977 Dorsomorphin Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T3220 Euphorbiasteroid Euphorbiasteroid (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
T13265 Urolithin B Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhance...
T16099 MK8722 MK8722 is an effective and systemic activator of pan-AMPK.
T13411 ZLN024 ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, ...
T2750 Ginkgolide C Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
TN1670 Ganodermanondiol Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T3889 Platycodin D Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
T7955 EB-3D EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
TN6751 1-HEXACOSANOL Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T8740 COH-SR4 SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inh...
T9191 XMD-17-51 Trifluoroacetate XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.
T0853L Adenosine 5'-monophosphate monohydrate Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
T8929 BC1618 BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
TN1990 Norathyriol Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T6854 GSK621 GSK621 is a specific and potent AMPK activator.
T19500 Palmitelaidic Acid Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
T2374 HTH-01-015 HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
T2133 Adenosine monophosphate Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
T3405 [6]-Gingerol 6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
TQ0028 EX229 EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
T1020 Doxorubicin hydrochloride Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
T16113 ML753286 ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
T11947 MARK4 inhibitor 1 MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
T1453 Phenformin hydrochloride Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T7362 O-304 O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
T6285 GSK-690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
TN1100 Nepodin Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
T2854 Phillyrin Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the express...
T20029 Buformin hydrochloride Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointe...
T6129 GSK-1070916 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
T7327 7-Methoxyisoflavone 7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
T9219 WH-4-025 WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
T3863 Chikusetsusaponin IVa Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a...
TN1440 Beta-Hydroxyisovalerylshikonin Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
T2468 A-769662 A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T5993 ARN-3236 ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
T2978 Mogroside V Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
TN1836 Kudinoside D Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
T2746 Sophocarpine monohydrate Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T3S0195 Nootkatone 1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
T10312 Ampkinone Ampkinone is an indirect AMPK activator.
TN1499 Cimiracemoside C Cimiracemoside C is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.
T5187 MK-3903 MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
T1477 AICAR Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...
YM-53601 free base
T13371
YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
Methyl cinnamate
T5552
Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
Hernandezine
TN1731
Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
Danthron
T0800
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
Dorsomorphin
T1977
Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
Euphorbiasteroid
T3220
Euphorbiasteroid (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
Urolithin B
T13265
Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enha...
MK8722
T16099
MK8722 is an effective and systemic activator of pan-AMPK.
ZLN024
T13411
ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µ...
Ginkgolide C
T2750
Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
Ganodermanondiol
TN1670
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
Platycodin D
T3889
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat periton...
EB-3D
T7955
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
1-HEXACOSANOL
TN6751
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
COH-SR4
T8740
SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inh...
XMD-17-51 Trifluoroacetate
T9191
XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.
Adenosine 5'-monophosphate monohydrate
T0853L
Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
BC1618
T8929
BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
Norathyriol
TN1990
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
GSK621
T6854
GSK621 is a specific and potent AMPK activator.
Palmitelaidic Acid
T19500
Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
HTH-01-015
T2374
HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
Adenosine monophosphate
T2133
Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
[6]-Gingerol
T3405
6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
EX229
TQ0028
EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
Doxorubicin hydrochloride
T1020
Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
ML753286
T16113
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
MARK4 inhibitor 1
T11947
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (...
Phenformin hydrochloride
T1453
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
O-304
T7362
O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
GSK-690693
T6285
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
Nepodin
TN1100
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
Phillyrin
T2854
Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the express...
Buformin hydrochloride
T20029
Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointe...
GSK-1070916
T6129
GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
7-Methoxyisoflavone
T7327
7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
WH-4-025
T9219
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
Chikusetsusaponin IVa
T3863
Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into ...
Beta-Hydroxyisovalerylshikonin
TN1440
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
A-769662
T2468
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
ARN-3236
T5993
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
Mogroside V
T2978
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
Kudinoside D
TN1836
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
Sophocarpine monohydrate
T2746
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
Nootkatone
T3S0195
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
Ampkinone
T10312
Ampkinone is an indirect AMPK activator.
Cimiracemoside C
TN1499
Cimiracemoside C is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.
MK-3903
T5187
MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
AICAR
T1477
Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...
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