AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat No.	product name
T0740	Metformin hydrochlorideHOT	Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including ...
T6146	Dorsomorphin dihydrochlorideHOT	Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
T5576	YKL-06-061	YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
T4599	HG-9-91-01	HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respecti...
T3S0195	Nootkatone	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
T2746	Sophocarpine monohydrate	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T5162	MRT67307 HCl (1190378-57-4(free base))	MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T5187	MK3903	MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
T5993	ARN-3236	ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
T5497	AMAROGENTIN	Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell ...
T6129	GSK1070916	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
T7362	O-304	O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
T7327	7-Methoxyisoflavone	7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
T7535	3-Guanidinopropionic Acid	3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and...
TQ0028	EX229	EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
TN1100	Nepodin	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
T4427	PF06409577	PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
T1977	Dorsomorphin	Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T2978	Mogroside V	Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
T3405	6-Gingerol	6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
T0800	Antrapurol	Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T6291	WZ4003	WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 othe...
T6854	GSK621	GSK621 is a specific and potent AMPK activator.
T2750	Ginkgolide C	Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
T2374	HTH-01-015	HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
T0853L	Adenosine 5'-monophosphate monohydrate	Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
T1477	AICAR (Acadesine)	Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...
TN1189	13-Methylberberine	13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug
T2854	Forsythin	Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the express...
T3863	Chikusetsusaponin IVa	Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into ...
T3676	Sesamol	Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upreg...
T2133	Adenosine 5'-monophosphate	Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
T1453	Phenformin hydrochloride	Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T2468	A 769662	A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
TN1140	Onjisaponin B	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-...
T9191	XMD-17-51 Trifluoroacetate (1628614-50-5 free base)	XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.
TN6751	1-HEXACOSANOL	Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T22460	XMD-17-51	XMD-17-51 is a potent and highly selective NUAK1 inhibitor.
T16113	ML753286	ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
T16156	MT 63-78	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathwa...
T16166	N-[(4-Aminophenyl)methyl]adenosine	N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase).
T16240	N,N'-Diacetyl-L-cystine	N,N'-diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effect...
T3904	Gomisin J	Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic e...
T8526	Metformin	Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorptio...
T2S0820	Karanjin	Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. ...
T13371	YM-53601 free base	YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
TL0014	Pinusolide	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN3042	4-Hydroxycinnamamide	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN4382	Kazinol A	Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag...
TN5013	Shizukaol D	Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be...
T20029	Buformin hydrochloride	Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointe...
T8929	BC1618	BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
T16099	MK8722	MK8722 is an effective and systemic activator of pan-AMPK.
T8432	ASP4132	ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
TN1499	Cimiracemoside C	Cimiracemoside C is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.
TN1911	Marein	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
TN1670	Ganodermanondiol	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TN1731	Hernandezine	Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
TN1828	Kahweol	Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
TN1836	Kudinoside D	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
TN1868	Ligupurpuroside A	Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
TN1870	Ligupurpuroside C	Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
TN1990	Norathyriol	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T10789	Chitosan oligosaccharide	Chitosan oligosaccharide, an oligomer of β-(1→4)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways.
TN2097	Pomolic acid	Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
T10105	3α-Hydroxymogrol	3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
T14149	AICAR phosphate	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinf...
T10312	Ampkinone	Ampkinone is an indirect AMPK activator.
T8476	RSVA 405	RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T11570	HL271	HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
T13265	Urolithin B	Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enha...
TN1440	Beta-Hydroxyisovalerylshikonin	Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...