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PI3K/Akt/mTOR signaling AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
Cat No. product name
T0740 Metformin hydrochlorideHOT Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells includi...
T0800 Antrapurol Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T1453 Phenformin hydrochloride Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T1477 AICAR (Acadesine) Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating oth...
T1977 Dorsomorphin Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T2133 Adenosine 5'-monophosphate Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
T2374 HTH-01-015 HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
T2468 A 769662 A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T3676 Sesamol Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upr...
T3863 Chikusetsusaponin IVa Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed int...
T6146 Dorsomorphin dihydrochlorideHOT Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
T6291 WZ4003 WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 oth...
T4427 PF-06409577 PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
T3S0195 Nootkatone 1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent...
T2S0410 Euphorbia factor L1
T2854 Forsythin Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expres...
T2978 Mogroside V Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edem...
T5187 MK-3903 MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
T5497 AMAROGENTIN Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell...
T5576 YKL-06-061 YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
T5993 ARN-3236 ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectivel...
T7362 O-304 O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
T7327 7-Methoxyisoflavone 7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
TQ0028 EX229 EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
T4599 HG-9-91-01 HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respecti...
TN1140 Onjisaponin B Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±...
TN1440 Beta-Hydroxyisovalerylshikonin Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in...
TN1499 Cimiracemoside C The Cimicifuga racemosa extract Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and cimiracemoside C) can reduce significantly body weight, ...
TN1731 Hernandezine Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
TN1868 Ligupurpuroside A Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
TN1870 Ligupurpuroside C Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
TN1911 Marein Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation ...
TN1100 Nepodin Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
TN1189 13-Methylberberine 13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug
TN1836 Kudinoside D Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
TN1990 Norathyriol Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
TN1670 Ganodermanondiol Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
TN2097 Pomolic acid Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-media...
T10105 3α-Hydroxymogrol 3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
T14149 AICAR phosphate AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
T10312 Ampkinone Ampkinone is an indirect AMPK activator.
T8476 RSVA 405 RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T11570 HL271  HL271 attenuates aging-associated cognitive impairment. HL271, a chemical derivative of metformin , is a potent AMPK activator that increases AMPK phosphoryl...
T10789 Chitosan oligosaccharide Chitosan oligosaccharide, an oligomer of β-(1→4)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways.
T8432 ASP4132 ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
T13371 YM-53601 free base YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
T16113 ML753286 ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP ...
T16166 N-[(4-Aminophenyl)methyl]adenosine N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase).
T16240 N,N'-Diacetyl-L-cystine N,N'-diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effec...
T3904 Gomisin J Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic ...
Metformin hydrochloride HOT
T0740CAS 1115-70-4
Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells includi...
Antrapurol
T0800CAS 117-10-2
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
Phenformin hydrochloride
T1453CAS 834-28-6
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
AICAR (Acadesine)
T1477CAS 2627-69-2
Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating oth...
Dorsomorphin
T1977CAS 866405-64-3
Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
Adenosine 5'-monophosphate
T2133CAS 61-19-8
Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
HTH-01-015
T2374CAS 1613724-42-7
HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
A 769662
T2468CAS 844499-71-4
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
Sesamol
T3676CAS 533-31-3
Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upr...
Chikusetsusaponin IVa
T3863CAS 51415-02-2
Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed int...
Dorsomorphin dihydrochloride HOT
T6146CAS 1219168-18-9
Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
WZ4003
T6291CAS 1214265-58-3
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 oth...
PF-06409577
T4427CAS 1467057-23-3
PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
Nootkatone
T3S0195CAS 4674-50-4
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent...
Euphorbia factor L1
T2S0410CAS 76376-43-7
Forsythin
T2854CAS 487-41-2
Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expres...
Mogroside V
T2978CAS 88901-36-4
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edem...
MK-3903
T5187CAS 1219737-12-8
MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
AMAROGENTIN
T5497CAS 21018-84-8
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell...
YKL-06-061
T5576CAS 2172617-15-9
YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
ARN-3236
T5993CAS 1613710-01-2
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectivel...
O-304
T7362CAS 1261289-04-6
O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
7-Methoxyisoflavone
T7327CAS 1621-56-3
7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
EX229
TQ0028CAS 1219739-36-2
EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
HG-9-91-01
T4599CAS 1456858-58-4
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respecti...
Onjisaponin B
TN1140CAS 35906-36-6
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±...
Beta-Hydroxyisovalerylshikonin
TN1440CAS 7415-78-3
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in...
Cimiracemoside C
TN1499CAS 256925-92-5
The Cimicifuga racemosa extract Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and cimiracemoside C) can reduce significantly body weight, ...
Hernandezine
TN1731CAS 6681-13-6
Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
Ligupurpuroside A
TN1868CAS 147396-01-8
Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
Ligupurpuroside C
TN1870CAS 1194056-33-1
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
Marein
TN1911CAS 535-96-6
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation ...
Nepodin
TN1100CAS 3785-24-8
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, w...
13-Methylberberine
TN1189CAS 54260-72-9
13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug
Kudinoside D
TN1836CAS 173792-61-5
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
Norathyriol
TN1990CAS 3542-72-1
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
Ganodermanondiol
TN1670CAS 107900-76-5
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
Pomolic acid
TN2097CAS 13849-91-7
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-media...
3α-Hydroxymogrol
T10105CAS 1343402-73-2
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation.
AICAR phosphate
T14149CAS 681006-28-0
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proin...
Ampkinone
T10312CAS 1233082-79-5
Ampkinone is an indirect AMPK activator.
RSVA 405
T8476CAS 140405-36-3
RSVA 405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
HL271
T11570CAS 1422365-52-3
 HL271 attenuates aging-associated cognitive impairment. HL271, a chemical derivative of metformin , is a potent AMPK activator that increases AMPK phosphoryl...
Chitosan oligosaccharide
T10789CAS 148411-57-8
Chitosan oligosaccharide, an oligomer of β-(1→4)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways.
ASP4132
T8432CAS 1640294-30-9
ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
YM-53601 free base
T13371CAS 182959-28-0
YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
ML753286
T16113CAS 1699720-89-2
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP ...
N-[(4-Aminophenyl)methyl]adenosine
T16166CAS 95523-13-0
N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase).
N,N'-Diacetyl-L-cystine
T16240CAS 5545-17-5
N,N'-diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effec...
Gomisin J
T3904CAS 66280-25-9
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic ...