AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat No.	product name
T13371	YM-53601 free base	YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
T5552	Methyl cinnamate	Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
TN1731	Hernandezine	Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
T0800	Danthron	Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T1977	Dorsomorphin	Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T3220	Euphorbiasteroid	Euphorbiasteroid (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
T13265	Urolithin B	Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhance...
T16099	MK8722	MK8722 is an effective and systemic activator of pan-AMPK.
T13411	ZLN024	ZLN024 is an activator of AMPK allosteric(AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, ...
T2750	Ginkgolide C	Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
TN1670	Ganodermanondiol	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TL0014	Pinusolide	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T3889	Platycodin D	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal...
T7955	EB-3D	EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.
TN6751	1-HEXACOSANOL	Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T8740	COH-SR4	SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inh...
T9191	XMD-17-51 Trifluoroacetate	XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.
T0853L	Adenosine 5'-monophosphate monohydrate	Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleo...
T8929	BC1618	BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves...
TN1990	Norathyriol	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T6854	GSK621	GSK621 is a specific and potent AMPK activator.
T19500	Palmitelaidic Acid	Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
T2374	HTH-01-015	HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
T2133	Adenosine monophosphate	Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
T3405	[6]-Gingerol	6-Gingerol, an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bo...
TQ0028	EX229	EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
T1020	Doxorubicin hydrochloride	Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also inhibits topoisomerase II.
T16113	ML753286	ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (...
T11947	MARK4 inhibitor 1	MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (M...
T1453	Phenformin hydrochloride	Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T7362	O-304	O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
T6285	GSK-690693	GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
TN1100	Nepodin	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
T2854	Phillyrin	Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the express...
T20029	Buformin hydrochloride	Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointe...
T6129	GSK-1070916	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related ...
T7327	7-Methoxyisoflavone	7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).
T9219	WH-4-025	WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.
T3863	Chikusetsusaponin IVa	Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a...
TN1440	Beta-Hydroxyisovalerylshikonin	Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
T2468	A-769662	A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T5993	ARN-3236	ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively...
T2978	Mogroside V	Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
TN1836	Kudinoside D	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.
T2746	Sophocarpine monohydrate	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T3S0195	Nootkatone	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
T10312	Ampkinone	Ampkinone is an indirect AMPK activator.
TN1499	Cimiracemoside C	Cimiracemoside C is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.
T5187	MK-3903	MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).
T1477	AICAR	Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...