turnover — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7469	Alendronic Acid	alendronate	Others
	Alendronic Acid (alendronate) is a nonhormonal medication used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.		Others
T8112	β-Gentiobiose		Others
	β-Gentiobiose is a natural oligosaccharide that promotes fruit ripening days.		Others
T1850	Balicatib	AAE581	Cysteine Protease
	Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.		Cysteine Protease
T20319	Pentabromophenol	NSC 5717,NSC5717,NSC-5717	TGF-beta/Smad
	Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.		TGF-beta/Smad
T0308	Etidronic acid	HEDPA,Etidronate,HEDP	Apoptosis , Phosphatase , Others , HBV
	Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.		Apoptosis , Phosphatase , Others , HBV
T2820	Glycitin	Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside	Others , Influenza Virus , Antibacterial
	Glycitin (Glycitein 7-O-β-glucoside), a natural isoflavone isolated from legumes, can promote the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.		Others , Influenza Virus , Antibacterial
T19649	PF-06273340	PF 6273340,PF 06273340,PF6273340,PF-6273340	Trk receptor
	PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflu...		Trk receptor
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T77581	KM02894		GluR
	KM02894 is a glutamate release inhibitor. Cancer cells release high levels of glutamate that can disrupt normal bone turnover, which can lead to cancer-induced bone pain.KM02894 may be used in the study of tumor-related ...		GluR
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T4746	Purine	7H-Imidazo(4,5-d)pyrimidine	Others , Endogenous Metabolite
	Purine (7H-Imidazo(4,5-d)pyrimidine) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Two of the bases in nucleic acids, adenine and guanine, are purines. Purines f...		Others , Endogenous Metabolite
T1631	Sulbactam	CP45899	Antibacterial , Antibiotic
	Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol...		Antibacterial , Antibiotic
T6S2140	β-Anhydroicaritin	Anhydroicaritin,Beta-Anhydroicaritin	MMP , Others , TNF , Interleukin
	1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ...		MMP , Others , TNF , Interleukin
T36971	5-Ethynyluridine		Nucleoside Antimetabolite/Analog
	5-Ethynyluridine is a clickable form of uridine.1It is incorporated into cellular RNA, but not DNA, and has been used to detect transcriptionin vitroandin vivo. 1.Jao, C.Y., and Salic, A.Exploring RNA transcription and t...		Nucleoside Antimetabolite/Analog
T36949	Niaprazine		5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2]. Niaprazine exhibits a low aff...		5-HT Receptor , Adrenergic Receptor , Histamine Receptor
T31940	Glucosylgalactosylhydroxylysine	Hydroxylysine-glucose-galactose
	Glucosylgalactosylhydroxylysine is a bone formation and bone resorption marker that is related to bone turnover processes during growth and development as well as metabolic bone diseases.
T24612	Pentachloropseudilin	PClP
	Pentachloropseudilin is a selective inhibitor of Myosin-1. In target cells, It acts by suppressing transforming growth factor-β activity by accelerating cell-surface type II TGF-β receptor turnover.
T70983	Zoledronate disodium
	Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma.
T11798	L-692429	MK-0751	GHSR , GPCR19
	L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by glucocorticoids.L-692429 has a high affinity for the G prot...		GHSR , GPCR19
T76113	Creatine kinase (OcCK)
	Creatine kinase (OcCK) catalyzes the reversible reaction of creatine and ATP to form phosphocreatine and ADP. Creatine kinase (OcCK) is a key enzyme for maintaining a constant ATP/ADP ratio during rapid energy turnover [...