t 247

HDAC3-IN-T247 (HDAC3 inhibitor T247) is a selective and potent histone deacetylase 3 (HDAC3) inhibitor with anticancer and antiviral activities.HDAC3-IN-T247 induces NF-κB acetylation in human colon cancer HCT116 cells in a dose-dependent manner.HDAC3-IN-T247 inhibits cancer cell proliferation. HDAC3-IN-T247 inhibits cancer cell proliferation.

Antibacterialagent 247 (compound 30b) is a bacterium (bacterial) antagonist that significantly inhibits the formation of biofilms by Pseudomonas aeruginosa (IC50=5.8 μM) and various virulence phenotypes. It also enhances the antibacterial activity of combined treatments with tobramycin and polymyxin B.

SAMT-247 is an HIV inhibitor that acts by modifying the nucleocapsid NCp7 region of Gag in infected cells and blocking Gag processing and reducing infectivity.

ST247 is a potent PPARβ/δ inverse agonist with a high affinity for PPARβ/δ and is able to inversely regulate the expression of the activation marker CCL2. ST247 inhibits agonist-induced transcriptional activity of PPARβ/δ. ST247 efficiently induces interaction with co-repressors.

GAD65(247-266) epitope TFA, a T cell epitope derived from islet antigens, exhibits competitive binding to the type I diabetes-associated molecule I-A g7, albeit with low affinity. This epitope corresponds to a sequence within Glutamic Acid Decarboxylase 65, an enzyme implicated in the transformation of glutamate into gamma-aminobutyric acid (GABA) [1].