staphylococcal

Antistaphylococcal agent 2 is an anti-staphylococcal therapeutic agent.

Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent designed to combat Staphylococcus infections.

Antistaphylococcal agent 1 is an antistaphylococcal therapeutic agent [antistaphylococcal agent 1].

EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP)-triggered protein synthesis.

Lincomycin hydrochloride monohydrate (Lincomycin hydrochloride hydrate) is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentrations (sub-MICs). It acts by suppressing Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1), and alpha-haemolysin (Hla) production. Resistance to this compound emerges through enzymatic methylation at the antibiotic's 50S ribosomal subunit binding site (23S rRNA).

Cefaloridine is a first-generation semisynthetic derivative of cephalosporin C. It is unique among cephalosporins in that it exists as a zwitterion. Cephaloridine was very effective to cure pneumococcal pneumonia. It has a high clinical and bacteriologica

Albocycline is a Macrolide antibiotic from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains.

Ristocetin is an antibiotic isolated from Amycolatopsis lurida that is previously used to the treatment of staphylococcal infections. It is no longer used clinically because it caused thrombocytopenia and platelet agglutination.

HT-61, a pyrroloquinolone antibiotic, is used potentially for the treatment of staphylococcal infections.

Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1]. Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These two assays could be used to diagnosis the von Willebrand disease and other bleeding disorders [2, 3]. The structural features of Ristocetin A are similar to vancomycin.

FtsZ-IN-2 is an inhibitor of the bacterial cytokinin FtsZ and has an inhibitory effect on GTPase activity. ftsZ-IN-2 exhibited anti-staphylococcal effects with MIC values of 2 μg ml for both MSSA and MRSA.

Thymidine 3',5'-diphosphate tetrasodium (Deoxythymidine 3′,5′-diphosphate tetrasodium) acts as a selective inhibitor targeting staphylococcal nuclease, tudor domain-containing 1 (SND1, a MicroRNA regulatory complex RISC subunit), and [3,5-2H2] tyrosyl nuclease. It possesses anti-tumor properties and serves as a catalyst in various biochemical reactions [1] [2].

Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771), a broad-spectrum anti-staphylococcal agent, exhibits antibacterial activity against both Methicillin-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, effectively reducing these bacteria when phagocytosed by THP-1 monocytes [1].

Nafcillin sodium, an antibiotic, acts as a reversible inhibitor of β-lactamase, making it effective for research into staphylococcal infections [1] [2].

PSM-β, an active peptide isolated from Staphylococcus epidermidis, acts as an analog of staphylococcal toxins and is also known as a phenol-soluble modulin (PSM). PSM-β exhibits bacteriostatic properties and possesses minimal hemolytic activity [1] [2].

Pagibaximab, a chimeric IgG1 antibody, targets the lipoteichoic acid on the surfaces of S. aureus and S. epidermidis, and is utilized for the prevention of staphylococcal sepsis [1].

Omodenbamab, a humanized monoclonal antibody targeting Staphylococcal protein A (SpA), exhibits a dissociation constant (K D) of 0.0467 nM, effectively countering a crucial S. aureus evasion strategy by focusing on the cell wall component Protein A (SpA). It is applicable in the study of S. aureus bloodstream infections [1].

Kanamycin sulfate, a broad-spectrum antibiotic, is effective for treating severe staphylococcal or Gram-negative bacillary infections. This compound has been linked to ototoxicity [1] [2].

Antibacterial Agent 154 (Compound 7), a Fluoroquinolone derivative, exhibits broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria when administered orally. It has been shown to be effective in vivo using a mouse model of staphylococcal sepsis [1].

Bevifimod (PRTX-100), a highly purified variant of Staphylococcal protein A (SpA), is utilized in research on idiopathic thrombocytopenic purpura (ITP) [1] [2].

Levonadifloxacin arginine ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. It exhibits antibacterial activity against both methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus. Additionally, it reduces monocyte THP-1 phagocytosis of MRSA and MSSA strains.

Lincomycin-d3 is a deuterated compound of Lincomycin. Lincomycin has a CAS number of 7179-49-9. Lincomycin hydrochloride is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.