squalene

Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All higher organisms produce squalene, including humans. Squalene is an intermediate product in the synthesis of cholesterol and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity.

(E Z)-Squalene ((E Z)-AddaVax) regulates intracellular reactive oxidant species (ROS) production, induces apoptosis and necrosis in a concentration- and time-dependent manner, accumulates in the liver, and lowers hepatic cholesterol and triglycerides.

Squalene-2,3-diol is a natural product for research related to life sciences. The catalog number is TN5051 and the CAS number is 14031-37-9.

Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg mL, while showing only modest cytotoxicity.

Squalane is a lipid found in some fish oils (especially shark liver oil) and some vegetable oils. It has anticancer and antioxidant properties and is used as a skin moisturizer and emollient.

Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.

Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.

Terbinafine (TDT 067) is a synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important component of fungal cell membranes. As a result, this agent disrupts fungal cell membrane synthesis and inhibits fungal growth.

Turbinaric acid is a moderately cytotoxic squalene carboxylic acid isolated from brown algae (Turbinaria ornata).

Zaragozic acid A trisodium, a metabolite produced by fungi, serves as a reversible competitive inhibitor of squalene synthase.

Diplopterol is biosynthetic of squalene for use in acetobacter pasteurii in a cell-free system. It is a hopanoid and can be used as a substitute for sterols.

12-Hydroxy Stearic Acid is a low molecular weight organogel that prevents benzo(a)pyrene and squalene peroxide-induced hyperpigmentation in the skin.