splice — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22215	1-Naphthyl phosphate potassium salt		Phosphatase
	1-Naphthyl phosphate potassium salt inhibits non-specific phosphatase.		Phosphatase
T6797	Telaglenastat	CB 839,CB839,CB-839	transporter , Glutaminase , Autophagy
	Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.		transporter , Glutaminase , Autophagy
T1901	(E/Z)-TG003	TG003	BCL , CDK
	(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.		BCL , CDK
T69308	Spliceostatin A		Apoptosis
	Spliceostatin A is an anticancer agent and splicing inhibitor that inhibits the splicing mechanism of the spliceosome and inhibits mitotic clonal expansion and adipogenesis.Spliceostatin A induces cell cycle arrest in th...		Apoptosis
TQ0209	Ailanthone	Δ13-Dehydrochaparrinone	Androgen Receptor
	Ailanthone (Δ13-Dehydrochaparrinone) is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 309 nM).		Androgen Receptor
T64387	2-Nitrobenzoic acid	o-Nitrobenzoic acid	Others
	2-Nitrobenzoic acid (o-Nitrobenzoic acid) is a antiproliferation agent. 2-Nitrobenzoic acid shows IC50 of 8.3 μM to jurkat cell line expressing T type calcium channel alpha 1H or its splice variant delta 25.		Others
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T35856	BMS-986176		AAK1 (AP2 associated kinase 1)
	AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A...		AAK1 (AP2 associated kinase 1)
T61820	Ar-V7-IN-1
	Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indication...
T79612	Tyrosine kinase-IN-6		c-Met/HGFR
	Tyrosine kinase-IN-6 is a potent inhibitor of RON splice variants, demonstrating significant anticancer and antineoplastic effects [1].		c-Met/HGFR
T39071	Thailanstatin D
	Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point...
T81912	LSP-GR3		iGluR
	LSP-GR3, a novel splice modulating oligomer (SMO) consisting of chemically-modified RNA oligonucleotides, potently and specifically directs the alternative splicing of GluR to promote GluR3-flip expression across the cen...		iGluR
T71113	Minnelide free acid
	Minnelide is an effective therapy against pancreatic cancer. Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variant...
T39309	Telaglenastat hydrochloride	CB-839 hydrochloride
	Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1). It selectively inhibits the splice variants of GLS1, specifically KGA (kidney-type glutaminase) a...
T63811	EPI-7170
	EPI-7170 is a ralaniten analogue and a potent antagonist of the androgen receptor N-terminal structural domain, blocking the transcriptional activity of the full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170...
T41016	Vercirnon sodium	GSK-1605786 sodium,CCX282-Bsodium,Traficet-ENsodium
	Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent CCR9 antagonist. It effectively inhibits CCR9-mediated calcium mobilization and chemotaxis in Molt-4 cells, exhibiting IC50 values of 5.4 nM...
T78810	BWA-522		Androgen Receptor
	BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL) and the AR-V7 splice variant. It specifically antagonizes the...		Androgen Receptor