polymerases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8647	BCH001		DNA/RNA Synthesis
	BCH001 is a specific small-molecule inhibitor of PAPD5.		DNA/RNA Synthesis
T5539	GS-443902		Nucleoside Antimetabolite/Analog , HCV Protease , SARS-CoV , DNA/RNA Synthesis , RSV , Drug Metabolite
	GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks
T4377	Pimodivir	VX-787	Influenza Virus
	Pimodivir (VX-787), an influenza A virus polymerases inhibitor via oral, interacts with the viral PB2 subunit.		Influenza Virus
T7004	Tubercidin	Sparsomycin A,7-Deazaadenosine	Influenza Virus , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Tubercidin (Sparsomycin A), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhib...
T5288	Cytidine-5'-triphosphate disodium	CTP,Cytidine 5'-triphosphate (disodium salt)	Others , Endogenous Metabolite
	Cytidine-5'-triphosphate disodium (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. Cytidine-5'-triphosphate disodium is used in the synthesis of RNA by RNA polymerases...		Others , Endogenous Metabolite
T9618	HeE1-2Tyr		SARS-CoV
	HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.		SARS-CoV
T7042	1,5-Isoquinolinediol		PARP
	1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...		PARP
T4010	Juglone	5-Hydroxy-1,4-naphthoquinone,Regianin	DNA/RNA Synthesis , Antibacterial
	Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin fam...		DNA/RNA Synthesis , Antibacterial
T29431	4'-Azidothymidine 5'-triphosphate	Adrt TP,Adrt-TP,AdrtTP
	4'-Azidothymidine 5'-triphosphate exerts selectively action on both reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta.
T70961	Dmb-rifampicin
	Dmb-rifampicin is an inhibitor of nucleic acid polymerases.
T69384	AF-013
	AF-013 is a rifamycin derivative -- specifically an O-n-octyloxime of 3-formylrifamycin SV -- which acts as an inhibitor of nucleic acid polymerases.
T37910	Tenofovir diphosphate triethylamine
	Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive inhibitor of DNA polymerases for dATP, functioning as a substrate for HIV type 1 reverse transcriptase (HIV-1 RT)[1].
T75344	NCT-TFP
	NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].
T1454L	Acyclovir sodium	Aciclovir sodium
	Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.
T37909	Tenofovir diphosphate
	Tenofovir diphosphate (TFV-DP) is a competitive inhibitor of DNA polymerases, specifically targeting dATP, and it serves as a substrate for the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1)[1]...
T70284	Epolactaene
	Epolactaene is a neuritogenic compound in human neuroblastoma cells which selectively inhibit the activities of mammalian DNA polymerases and human DNA topoisomerase II.
T13852	PSI-7409 tetrasodium		Others
	PSI-7409 tetrasodium, the active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), exhibits specific inhibitory activity against NS5B polymerases of various genotypes, with IC50s being 1.6 μM for GT 1b_Con1, 2.8 μM fo...		Others
T38761	GS-443902 trisodium	GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
	GS-443902 trisodium (GS-441524 triphosphate trisodium), the active triphosphate metabolite of Remdesivir (GS-5734), serves as a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), displaying inhibitory concen...
T32050	HCV-371	HCV 371
	HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ a...
T16945	Streptolydigin	Portamycin	Antibacterial
	Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki...		Antibacterial