p120γ

Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).

E 3040 is a dual inhibitor of 5-lipoxygenase and thromboxane synthase with oral activity. E 3040 exhibits anti-inflammatory activity .

YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.

gp120-α4β7 binding inhibitor 11 is an anti-HIV agent. gp120-α4β7 binding inhibitor 11 interferes the binding of HIV associated glycoprotein gp12G with the integrin α4β7 (IC50=1.64nM).

Morantel tartrate (CP-12009-18 tartrate) is an antinematodal agent used mainly for livestock.

Hexaminolevulinate hydrochloride (P-1206) has approved for cystoscopic detection of papillary bladder cancer and it also is a fluorescent agent.

Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17α,20-dimethyl-δ2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.

NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.

MP1202 is a dual agonist for MOR and KOR, with EC50 values of 0.32 μM for mMOR-1 and 0.13 μM for mKOR-1. It exhibits functional selectivity by reducing β-arrestin1/2 recruitment in hMOR and hKOR while significantly activating G protein and Gα subtypes. In opioid receptor subtype knockout mouse models, MP1202 demonstrates potent antinociceptive effects without typical opioid side effects, albeit it induces conditioned place preference and aversion behaviors, indicating potential for analgesic research.

Anti-Mouse CD4 Antibody (2G5.D) is an anti-mouse CD4 antibody widely used in research and experiments in the field of life sciences.

gp120-IN-2 (compound 4i) is a potent inhibitor of HIV-1 gp120, demonstrating anti-HIV-1 activity with an IC50 of 7.5 μM and a CC50 of 112.93 μM. It shows dose-dependent cytotoxicity in SUP-T1 cells [1].

gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with a CC50 of 100.90 μM and IC50 of 2.2 μM, inhibiting gp120-mediated virus entry into cells and exhibiting anti-HIV-1 activity with dose-dependent cytotoxicity in SUP-T1 cells [1].

SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.

ZP 120C, a potent and partial ORL1 receptor agonist, effectively inhibits electrically induced contraction. It is utilized in the research of hyponatremia/hypokalemia [1] [3].

DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.

GP120, HIV-1 MN, a peptide, is utilized in researching HIV infection [1] [2].

Zinlirvimab (10-1074) is a humanized IgG1-λ2 monoclonal neutralizing antibody that targets the gp120/CD4 interface on the HIV-1 envelope glycoprotein receptor to effectively prevent viral attachment. Zinlirvimab (10-1074) inhibits the complex process of viral entry into host CD4+ T cells by recognizing and binding to specific conserved epitopes, thereby effectively preventing the Human Immunodeficiency Virus from establishing a productive and systemic infection. Zinlirvimab (10-1074) exhibits a remarkably optimized pharmacological profile with a significantly extended half-life through specialized Fc-region modifications, facilitating its role as a persistent agent for sustained viral suppression.

Zanolimumab is a humanised monoclonal antibody targeting CD4, exhibiting cytotoxic and antiproliferative properties. By binding to the CD4 molecule and blocking T cell receptor (TCR) signalling, it is used in the treatment of autoimmune diseases such as rheumatoid arthritis, psoriasis, and T-cell lymphoma.

Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20), a dodecapeptide fragment of retinoid-binding protein 3, plays a crucial role in pigment regeneration by facilitating the transport of retinol and retinal between photoreceptor cells and the retinal pigment epithelium. It has been utilized to provoke autoimmune uveoretinitis in C57BL/6 mice, possessing the H-2b haplotype. Furthermore, IRBP1-20 at a concentration of 3 µM enhances the secretion of IL-4, IL-5, and IL-6 from primary mouse spleen lymphocytes. Immunization and subsequent rechallenge with IRBP1-20 lead to increased ear swelling, inflammation of ocular blood vessels, infiltration by immune cells, damage to the photoreceptor layer, and retinal detachment in IFN-γ-deficient mice.

Anti-HIV gp120 Antibody (55-36) is a chimeric mouse IgG1 κ antibody designed to target HIV gp120. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.

Lotivibart is a human-origin IgG1κ monoclonal antibody targeting the gp120 envelope glycoprotein. The corresponding isotype control for this compound is designated as HumanIgG1kappa, Isotype Control.

Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory and antitumor activity.

3,5,6,7,8,3',4'-Heptemthoxyflavone exhibits neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging, and photoprotective effects; it inhibits collagenase activity, induces type I procollagen synthesis in HDFn cells, and combats nitric oxide (NO) carcinogenesis.

(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).