mycobacteria

Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.

Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes, uncouples oxidative phosphorylation, and inhibits ATPase of rat liver mitochondria. The substance is primarily used as a biochemical tool to study the role of divalent cations in various biological systems.

1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.

Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG

Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.

Methyl caffeate (Methyl caffeate acid) acid

Linaroside exhibited 30% inhibition for antimycobacterial activity against Mycobacterium tuberculosis, strain H(37)Rv at 6.25 microg mL(-1) concentration.

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

Ostruthin (Ostruthine) is a natural coumarin with antimicrobial activity that can effectively inhibit the growth of a wide range of mycobacteria with a minimum inhibitory concentration of MIC= 3.4-107.4 μM.

Senfolomycin B exhibits activity against Gram-positive bacteria and mycobacteria, as well as effectiveness against penicillin-resistant, streptomycin-resistant, neomycin-resistant, and macrolide-antibiotic-resistant Staphylococcus aureus. Additionally, Senfolomycin A demonstrates weaker activity against Gram-negative bacteria.

Roseorubicin B exhibits activity against Gram-positive bacteria and mycobacteria. It also demonstrates inhibitory effects on leukemia cells L1210, with an IC50 of 0.06 μg/mL.

Napyradiomycin A2 is an antibiotic that exhibits activity against Gram-positive bacteria and mycobacteria.

Liposidomycin C exhibits antibacterial properties, though its activity is relatively weak. It shows significant inhibitory effects on mycobacteria with a minimum inhibitory concentration (MIC) of 0.16 μg/mL. Additionally, Liposidomycin C inhibits glycopeptide biosynthesis, effectively suppressing Escherichia coli glycopeptide biosynthesis with an IC50 of 0.03 μg/mL.

Nemotinic acid exhibits activity against Gram-positive bacteria, mycobacteria, and fungi, while also displaying weaker activity against Gram-negative bacteria.

Liposidomycin B exhibits antibacterial properties, although its activity is relatively weak. It shows a significant inhibitory effect on mycobacteria with an MIC of 0.16 μg/mL. Additionally, Liposidomycin B hinders glycopeptide biosynthesis, effectively inhibiting glycopeptide biosynthesis in Escherichia coli with an IC50 of 0.03 μg/mL.

Mannosyl glucosaminide is an aminoglycoside antibiotic with activity against bacteria, mycobacteria, and Saccharomyces cerevisiae (brewer's yeast).

Paromomycin II is an aminoglycoside antibiotic that exhibits activity against both Gram-positive and Gram-negative bacteria, mycobacteria, and protozoa. It is particularly effective in treating amoebic dysentery and certain bacterial dysentery cases.

Granaticin A inhibits the initial stages of RNA biosynthesis and exhibits activity against Gram-positive bacteria, mycobacteria (weak), and Trichomonas vaginalis, as well as tumor cells.

Hedamycin is an anthraquinone antibiotic exhibiting activity against Gram-positive bacteria, Gram-negative bacteria, mycobacteria, and yeasts (MIC of 0.031-3.2 μg/mL). It also inhibits rat duodenal adenocarcinoma, Walker 256 tumors in rats, HeLa cells, and the lysogenic Escherichia coli W1709 (λ) phage.

Mycoplanecin A is a cyclic peptide antibiotic with potent activity against mycobacteria, xanthomonads, and Staphylococcus aureus. Additionally, Mycoplanecin A exhibits moderate antibacterial effects on Xanthomonas oryzae. It also demonstrates antimicrobial activity against certain strains of actinobacteria.

Phleomycin E is a peptide-based antibiotic that is effective against Gram-positive and Gram-negative bacteria as well as mycobacteria. It extends the survival time of mice with transplanted Ehrlich ascites carcinoma and shows inhibitory effects on murine pulmonary solid tumors, with an IC50 of 0.31 μg/mL.

Cycloheptamycin exhibits activity against Gram-positive bacteria and mycobacteria.

Sakyomicin C is a benzoquinone antibiotic. It exhibits activity against Gram-positive bacteria and mycobacteria.

Carriomycin is an antibiotic isolated from Streptomyces hygroscopicus. It is effective against Gram-positive bacteria, mycobacteria, yeast, and fungi, and also serves as a potent anticoccidial agent.