mcf-7 cell lines

Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.

1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti-oxidant and anti-inflammatory effects.

1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP LIP CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562 ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K Akt NF-κB pathway, and probably served as a most promising agent for CML treatment.

Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.

Cedrelone is a citrulline analog and a phenazine biosynthesis-like domain protein (PBLD) activator.Cedrelone induces apoptosis in cancer cells.Cedrelone is a very potent inducer of apoptosis, causing cell cycle arrest.Cedrelone has insecticidal activity, inhibiting the growth of arrowhead venom of P. saucia and inhibiting moulting of the milkweed bug (Oncopeltus fasciatus). Cedrelone has insecticidal activity, inhibiting the growth of P. saucia and inhibiting moulting of the milkweed bug (Oncopeltus fasciatus).Cedrelone has antitumor effects and exhibits significant cytotoxicity against cancer cell lines such as -60, SMMC-7721, A-549, MCF-7, and SW480.Cedrelone is a very potent inducer of apoptosis, causing cell cycle arrest.Cedrelone is a very potent inducer of apoptosis, leading to cell cycle arrest.

Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).

27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide known for inducing apoptosis, exhibits antiproliferative effects on HeLa, A-549, and MCF-7 human cancer cell lines, as well as on normal Vero cells [1].

Sartorypyrone B, a 2β-acetoxyl analogue of chevalone C, is derived from the ethyl acetate extract of the culture of Neosartorya tsunodae (KUFC 9213), a fungus associated with marine sponges. This compound demonstrates potent growth inhibitory activity against MCF-7, NCI-H460, and A375-C5 cancer cell lines with GI50 values of 17.8, 20.5, and 25.0 μM, respectively, indicating its potential in the study of breast adenocarcinoma, non-small cell lung cancer, and melanoma [1].

Protoapigenone, an antineoplastic agent extracted from ferns, demonstrates notable inhibitory activity against various cancer cell lines, including Hep G2, Hep 3B, MCF-7, A549, and MDAMB-231. The respective IC50 values are 1.60, 0.23, 0.78, 3.88, and 0.27 μg mL [1].

Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester), a flavonoid derived from the aerial parts of Calligoum polygonoides, exhibits cytotoxic properties with IC50 values of 60.46 μg mL for HepG2 and 61.4 μg mL for MCF-7 cell lines [1].

Neotriptonoterpene, isolated from T. regelii, exhibits weak cytotoxicity against A2780, HepG2, and MCF-7 cell lines, with respective IC50 values of 65.80 µM, 35.45 µM, and 64.80 µM [1].

Changnanic acid (schisandrin), a triterpene compound, has demonstrated potential anti-tumor properties, exhibiting moderate cytotoxicity against human tumor cell lines Bel-7402 and MCF-7 with IC50s of 100 μM, and against HL-60 with an IC50 of 50.51 μM [1].

3,5-Dimethoxy-2,7-phenanthrenediol (compound 2), extracted from Combretum laxum roots, exhibits cytotoxicity against various human cancer cell lines, including 786-0, MCF-7, and NCI ADR-RES, with IC50 values of 73.26 μM, 118.40 μM, and 83.99 μM, respectively. Additionally, this phenanthrene compound demonstrates free radical scavenging activity, presenting an IC50 of 20.4 μM [1].

Compound 2, or 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide, is an ent-kaurene diterpenoid extracted from Rubescens rubescens. This compound exhibits cytotoxic activity against various cell lines, including EC-1, U87, A549, MCF-7, and HeLa, with IC50 values of 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, and 462.13 μM, respectively, as well as 180.09 μM against another unspecified line [1].

(19R,23E)-5b,19-Epoxy-19-ethoxycucurbita-6,23-diene-3b,25-diol, a cucurbitane-type triterpenoid, exhibited no activity against five cancer cell lines—MCF-7, HepG2, Du145, Colon205, and HL-60—when evaluated using the MTT assay [1].

6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg ml

Asiaticoside B, a triterpene glycoside isolated from Actaea asiatica, exhibits notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.

Anhydrosecoisolariciresinol can significantly decrease the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines at 50 and 100 microM.

Momordicoside F1 may have antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines.

Periplocoside M possesses observably antitumor activity against SMMC-7721( IC 50=12.9 ng L),Hela( IC 50=8.63 ng L) and MCF-7( IC 50=18.5 ng L) cancer cell lines.

Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60.

2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.

2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows significant antiviral (H1N1 and H3N2) activities, it also displays significant antimycobacterial activity (IC50=7.6 uM).

25-Anhydrocimigenol 3-O-beta-D-xyloside has notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.