kp-1

KP-1 is a selective fluorescent probe for labeling human pluripotent stem cells.

KP-14 is a PROTAC specifically designed to target KRAS.

KP-1212( SN-1212) is a nucleoside designed for the treatment of HIV by viral mutagenesis.

AKP-11 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing human S1P1. It reduces S1P1 surface expression and enhances Akt and ERK phosphorylation in CHO cells with S1P1-HA at a 100 nM concentration. At doses of 1.3 and 3 mg kg, AKP-11 lowers IFN-γ and IL-17 protein levels in the spinal cord and mitigates disease severity in a rat experimental autoimmune encephalomyelitis (EAE) model. Additionally, it decreases peripheral total lymphocyte and specific T cell subsets (CD4+, CD8+, and CD26L+ T cells) counts in both EAE rats and healthy controls at a 1.3 mg kg dosage.

NKP-1339 (IT-139) induces G2 M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.

SA1-III(KP1) is a bioactive peptide recognized for its anti-aging properties and is utilized as a cosmetic ingredient [1].

γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM, specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain plasma ratio (Kp, brain = 0.72) in mice [1].

ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance unchanged clearance rate of 1.6 56 L h kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.

Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody targeting complement protein C5, combined with the domains 1-5 of complement factor H (FH1-5). It exhibits anti-inflammatory and immunomodulatory properties. The isotype control for Vensobafusp alfa can be referred to as human IgG4(S228P) kappa.

Malolactomycin C (compound 1) is a macrocyclic lactone antifungal antibiotic isolated from the Streptomyces strain KP-3144. It effectively inhibits Botrytis cinerea (gray mold), thereby controlling various plant diseases, including gray mold infections.