human neutrophil elastase

NeutrophilElastase(NEG) serves as a biomaterial or organic compound applicable in life sciences research.

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

Lodelaben (Declaben, SC-39026) is a reversible, non-competitive inhibitor of human neutrophil elastase (HNE), characterized by specificity and potency (IC50=0.5 μM, Ki=1.5 μM).

GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase, displaying higher affinity for human elastase (Ki = 0.0168 nM) compared to rat (Ki = 3 nM), mouse (Ki = 1.8 nM), and rabbit (Ki = 58 nM) elastases [2]. It reduces myocardial infarct size following ischemia-reperfusion injury [1] and has potential for treating chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis, and various inflammatory diseases.

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).

Ono EI-601 is the main metabolite of ONO-5046, the human neutrophil elastase inhibitor .

CHF-6333 CATION is a compound that inhibits human neutrophil elastase.

FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef

BAY-85-8501 is a selective, reversible, and potent inhibitor of Human Neutrophil Elastase (HNE) with an IC50 of 65 pM.

Lonodelestat TFA (POL6014 TFA) is a potent and selective peptide inhibitor of human neutrophil elastase (hNE) with demonstrated oral activity, showing promise for cystic fibrosis (CF) research [1] [2] [3].

MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].

Tiprelestat, a potent inhibitor of human neutrophil elastase, exhibits antimicrobial and anti-inflammatory properties. It is utilized in the study of inflammation and immune diseases [1].

AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease (COPD).

5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) inhibits human neutrophil oxidative metabolism and elastase activity. 5,7-Dihydroxy-4-methylcoumarin has in vitro platelet antiaggregatory property. 5,7-Dihydroxy-4-methylcoumarin shows inhibition of the cyclooxygenase pathway.

ICI 200355 is an inhibitor of human neutrophil elastase.

2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.

JO146 is a protease inhibitor for Chlamydia trachomatis high temperature requirement A (CtHtrA) and human neutrophil elastase (HNE), with IC50 values of 21.86 μM for CtHtrA and 1.15 μM for HNE, respectively. It is effective in inhibiting bacterial infections.

BAY-678 racemate is a racemate of BAY-678, an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE; IC50: 20 nM).

MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.

Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K AKT mTOR signaling pathway. It can be used in acute lung injury acute respiratory distress syndrome research.

GW-475151 inhibits human neutrophil elastase (HNE).

Elafin, also referred to as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a protein that serves as a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3, particularly in the lung. Additionally, Elafin exhibits antibacterial properties against Pseudomonas aeruginosa and Staphylococcus aureus [1] [2] [3].