homology-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2269	Tetramethylcurcumin		Apoptosis , STAT
	Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e...		Apoptosis , STAT
T5049	NVP-BSK805	NVP-BSK805 2HCl,BSK 805	Tyrosine Kinases , JAK
	NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.		Tyrosine Kinases , JAK
T23372	SMIFH2		Others
	SMIFH2 is formin homology 2 (FH2) domains inhibitor.		Others
T7541	PTP inhibitor 1	PTP Inhibitor II	Phosphatase
	PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM.		Phosphatase
T13176	TNO155	Batoprotafib	Phosphatase
	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity.		Phosphatase
T7084	2-Bromo-4'-hydroxyacetophenone	SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide	Phosphatase
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SH...		Phosphatase
T14775	Bragsin2	6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2	Others
	Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase acti...		Others
T38965	EPQpYEEIPIYL
	EPQpYEEIPIYL, a phosphopeptide, is a ligand for the Src homology 2 (SH2) domain. It activates members of the Src family, such as Lck, Hck, and Fyn, through the binding interaction with SH2 domains.
T35489	1-O-Octadecyl-2-O-methyl-sn-glycerol
	1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). PIAs are known to target the pleckstrin homology domain of the serine/threonine kinase Akt and to induce apoptosis ...
T79186	STAT6-IN-3		STAT
	STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain. It is utilized in research studies focused on inflammatory disorders, includi...		STAT
T27013	CHS-111	CHS 111
	CHS-111 is a benzyl indazole compound. CHS-111 inhibits superoxide anion (O(2)(-)) generation. CHS-111 reduces the fMLP-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosy...
T76356	Neuropeptide Y (2-36) (porcine)
	Neuropeptide Y (2-36) (porcine) is a pig-sourced peptide closely resembling its rat and human counterparts with 97.14% homology. It acts as an agonist for rat neuropeptide receptors Y5, Y2, and Y1, demonstrating EC50 val...
T76263	Beinaglutide
	Beinaglutide, a recombinant human GLP-1 (rhGLP-1) polypeptide, exhibits nearly complete homology with human GLP-1 (7–36). It demonstrates dose-dependent effects in improving glycemic control, reducing food intake, delayi...
T36939	PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)	PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, als...
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II...