fibrous

LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8 0.8 5.3 16.7 nM for ALK1 2 3 6).

8-Nitroguanine is a product of DNA nitration damage caused by reactive nitrogen species and may be a potential biomarker for the progression of malignant fibrous histiocytoma.

9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg mL.

ATX inhibitor 9 is a thickened heteroaryl derivative compound and a potent inhibitor of ATX. Among them Autotaxin (ATX), also known as ENPP2, is a secreted enzyme highly expressed mainly in lung cancer cells, bronchial epithelial cells and alveolar macrophages.ATX inhibitor 9 has research potential for cancer or fibrous degenerative diseases.

Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cancer activity and can be used to study ossifying fibrous dysplasia (FOP) and cancer.

14-Pentadecenoic acid, a 15-carbon long-chain fatty acid with an alkene functional group on the terminal carbon of its aliphatic tail, has been observed to undergo oxidation due to the growth of M. cerificans at the expense of the parent alkene. This compound is utilized in the creation of fibrous scaffold biomaterials for tissue engineering purposes and in constructing metallomesogenic side-chain polymers for coating capillary columns in gas chromatography applications.

Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is a gelatin methacryloyl compound infused with green fluorescent molecules. This modification allows Green Fluorescent GelMA to function as a scaffold, facilitating the design of tissue models ranging from vascular systems to cartilage and bone, and promoting cell proliferation and dispersion. With 30% methacrylation and Green Fluorescent properties, it requires photo-initiator LAP to self-assemble into fibrous hydrogels, targeting bioactive adhesive sites to provide structural support and enable biodegradation. Its applications include cell culture, bio 3D printing, tissue engineering, among others.

GelMA (Gelatin Methacryloyl), with 60% methacrylation and Green Fluorescent properties, is a type of methylated gelatin incorporating fluorescent molecules. This compound functions as a scaffold for creating tissue analogs, such as those resembling the vascular system, cartilage, and bone, promoting cell proliferation and diffusion. To form fibrous hydrogels, GelMA requires the action of a photoinitiator LAP, allowing it to target bioactive adhesion sites to support and degrade in tissue cells. It is applicable in fields like cell culture, bio 3D printing, and tissue engineering.

GelMA (Gelatin Methacryloyl), with 90% methacrylation and green fluorescence, is a modification of gelatin achieved by grafting fluorescent molecules onto the polymer. Green Fluorescent Gelatin Methacryloyl acts as a scaffold beneficial for creating tissue analogs ranging from the vascular system to cartilage and bone, promoting cell proliferation and diffusion. In the presence of the photoinitiator LAP, GelMA self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing essential support and biodegradability for tissue cells. Applications encompass cell culture, bio 3D printing, tissue engineering, among others.

Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is a variant of methacryloylated gelatin with red fluorescence, achieved by grafting fluorescent molecules onto GelMA. It acts as a scaffold and is suitable for designing tissue analogs from the vascular system to cartilage and bones, facilitating cell proliferation and dissemination. With 30% methacrylation, Red Fluorescent GelMA requires light initiator LAP to self-assemble into fibrous hydrogels, targeting bioactive adhesion sites while providing inherent support and biodegradability. Applications include cell culture, biological 3D printing, tissue engineering, and more.

Gelatin Methacryloyl, 30% methacrylation, blue fluorescent (GelMA, 30% methacrylation, blue fluorescent) is a type of GelMA that incorporates blue fluorescent molecules through its structure. It acts as a scaffold for creating tissue analogs, such as those of the vascular, cartilage, and skeletal systems, promoting cell proliferation and diffusion. Upon exposure to the photoinitiator LAP, it self-assembles into fibrous hydrogels, targeting bioactive adhesion sites to inherently support tissue cells and facilitate biodegradation. Applications include cell culture, bioprinting, and tissue engineering.

Chondroitin Sulfate Methacryloyl (CSMA) is a methacryloyl-modified form of chondroitin sulfate known for its biocompatibility. It exhibits a higher degree of methacrylic substitution compared to HAMA (HY-158220), which is closely linked to customizable mechanical properties, swelling behavior, and enzymatic degradability. CSMA serves as a versatile biomaterial suitable for biomimetic hydrogel scaffolds and is an ideal hydrogel ink for 3D printing. Under the influence of photoinitiator LAP, it self-assembles into a fibrous hydrogel targeting bioactive adhesion sites, supporting tissue cell interaction and biodegradation. It is applicable in areas such as cell culture, biological 3D printing, and tissue engineering.

Dextran Methacryloyl (MW 200000) is a methacrylated glucan that can transform into a cell matrix gel. The gel formed from Dextran Methacryloyl (MW 200000) shows no cytotoxicity towards fibroblasts, although cells exhibit only limited adhesion in prolonged experiments. In the presence of the photoinitiator LAP, it self-assembles into a fibrous hydrogel that targets bioactive adhesion sites, providing inherent support and biodegradability for tissue cells. It is applicable in areas such as cell culture, bio 3D printing, and tissue engineering.

Dextran Methacryloyl (DexMA) (MW 500000) is a methacrylated dextran that can transform into a cell matrix gel. The gel formed by Dextran Methacryloyl (MW 500000) is non-cytotoxic to fibroblasts; however, cell adhesion in long-term experiments is only marginally effective. Under the influence of the photoinitiator LAP, Dextran Methacryloyl (MW 500000) self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing inherent support and biodegradation activity for tissue cells. Application areas include cell culture, bio 3D printing, and tissue engineering.

GelMA (Gelatin Methacryloyl), with 60% methacrylation and red fluorescence, is a modified version of GelMA created by grafting fluorescent molecules onto it. It serves as a scaffold, facilitating the design of tissue analogs ranging from the vascular system to cartilage and bone, thus promoting cell proliferation and diffusion. In contrast, GelMA, 60% methacrylation with green fluorescence, requires LAP as a photoinitiator to self-assemble into fibrous hydrogels and target bioactive adhesion sites, providing inherent support to tissue cells and promoting biodegradability. This compound finds applications in cell culture, 3D bioprinting, and tissue engineering.

Gelatin Methacryloyl (GelMA) with 90% methacrylation and blue fluorescence is a modified form of gelatin achieved through the attachment of fluorescent molecules to GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold, facilitating the design of tissue analogs from vascular systems to cartilage and bone, promoting cell proliferation and migration. For GelMA with 90% methacrylation and green fluorescence, it requires the presence of a photoinitiator, specifically LAP, to self-assemble into fibrous hydrogels. These hydrogels target bioactive adhesion sites, providing inherent support for tissue cells and contributing to biodegradability. Applications include cell culture, bio 3D printing, and tissue engineering.

Alginate Methacryloyl (AlgMA) (MW 300000) is a methacryloyl-modified alginate known for its potential use in tissue engineering scaffolds and 3D printing inks. This compound exhibits biocompatibility, non-immunogenicity, and low toxicity, and can physically crosslink with divalent cations such as calcium. Under the influence of photoinitiator LAP, AlgMA self-assembles into fibrous hydrogels, targeting bioactive adhesion sites to provide inherent support to tissue cells and facilitate biodegradation. It is applicable in fields such as cell culture, biological 3D printing, and tissue engineering.

Poly-L-lysine Methacryloyl (PLMA) is a methacryloylated form of poly-L-lysine. When crosslinked on polyether ether ketone (PEEK) using ultraviolet initiation, PLMA enhances PEEK's hydrophilicity while maintaining its inherent non-degradable bio-inert properties. In the presence of the photoinitiator LAP (HY-44076), PLMA self-assembles into fibrous hydrogels, targets bioactive adhesion sites, and provides inherent support and biodegradability for tissue cells. Applications include cell culture, bio 3D printing, and tissue engineering.

GelMA (Gelatin Methacryloyl), with a methacrylation degree of 90%, is a derivative obtained from the reaction of gelatin with chitin anhydride (methacrylic anhydride, MA). The hydrogel formed by Gelatin Methacryloyl exhibits excellent biocompatibility and biodegradability, along with light cross-linking capability and adjustable physical properties. Under the influence of the photoinitiator LAP (HY-44076), GelMA, 90% methacrylation, self-assembles into fibrous hydrogels targeting bioactive adhesion sites, providing inherent support and biodegradation activity to tissue cells. Its applications include cell culture, biological 3D printing, tissue engineering, drug delivery, and biosensor development.

Alginate Methacryloyl (MW 50000) is a methacryloyl-modified alginate that shows promise for use as a scaffold in tissue engineering and as a 3D printing ink. It is characterized by its biocompatibility, non-immunogenicity, and low toxicity, and can physically cross-link with divalent cations (e.g., calcium). With the aid of a photoinitiator LAP (HY-44076), it assembles into fibrous hydrogels targeting bioactive adhesion sites, supporting tissue cells inherently and exhibiting biodegradability. Applications include cell culture, bio 3D printing, and tissue engineering.

Heparin Methacrylate (HepMA) is a heparin derivative, modified with methacrylate, making it suitable as a material for tissue engineering scaffolds and as a bioink for 3D printing. Under the influence of the photoinitiator LAP (HY-44076), HepMA self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing inherent support to tissue cells and promoting biodegradation. Its applications include cell culture, bioprinting, and tissue engineering.

Carboxymethyl chitosan Methacryloyl (CMCSMA) is a methacryloylated form of carboxymethyl chitosan with properties suitable for 3D printing inks. Composite hydrogels made from this compound can effectively accelerate bone healing in infectious environments, as demonstrated in a rat model with femoral defects infected by Staphylococcus aureus. Carboxymethyl chitosan Methacryloyl requires the presence of a photoinitiator LAP (HY-44076) to self-assemble into fibrous hydrogels, targeting bioactive adhesion sites and providing inherent support for tissue cells along with biodegradability. Its applications include cell culture, bio 3D printing, and tissue engineering.

Elastin Methacrylated (ElaMA) is a protein that can recruit and modulate innate immune cells, enhancing vascular formation at wound sites and thereby improving tissue regeneration. This compound attracts large numbers of neutrophils and key M2 macrophages to wounds, inducing their infiltration into hydrogels. It exhibits excellent immunomodulatory properties, promoting superior angiogenesis, collagen deposition, and dermal regeneration. When used in combination with the photoinitiator LAP (HY-44076), ElaMA self-assembles into fibrous hydrogels, targeting bioactive adhesion sites and providing intrinsic support and biodegradation for tissue cells. It is applicable in fields such as cell culture, bio 3D printing, and tissue engineering.

Polyether F127 Diacrylate (F127DA) is a triblock copolymer derived from the acrylation of polyethylene glycol-polypropylene glycol-polyethylene glycol. It rapidly crosslinks and cures into a gel under UV and visible light with a photoinitiator. Polyether F127 Diacrylate displays excellent thermoresponsive gelation (temperature-induced gelation) properties and good biocompatibility. When used with the photoinitiator LAP, it self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing inherent support and biodegradability for tissue cells. Application areas include the biomedical field, serving as a drug carrier, wound dressing, cell carrier, shear protector, bio 3D printing material, and for tissue engineering.