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disease

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  • Inhibitors & Agonists
    2428
    TargetMol | Inhibitors_Agonists
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    43
    TargetMol | Compound_Libraries
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    177
    TargetMol | Peptide_Products
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    TargetMol | Disease_Modeling_Products
Finerenone
BAY94-8862, BAY-94-8862, BAY-948862, BAY948862, BAY 94-8862, BAY 948862
T213951050477-31-0
Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes.
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Selisistat
SEN0014196, EX-527
T611149843-98-3
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50 = 38 nM) and can be utilized in the study of neurological disorders such as Huntington's chorea.
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voxelotor
GBT 440
T75811446321-46-5
Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).
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MPTP hydrochloride
MPTP-hydrochloride
T408123007-85-4
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.
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gsk2292767
T68501254036-66-2In house
GSK2292767 is a potent and selective inhibitor of PI3Kδ.
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Imiquimod
S-26308, R 837, IMQ
T013499011-02-6
Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.
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Norharmane
β-Carboline, 2-Azacarbazole, 2,9-Diazafluorene
T4024244-63-3
Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
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Inosine
NSC 20262, INO 495
T043758-63-9
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
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Ropinirole hydrochloride
SKF-101468A, SKF 101468 hydrochloride, Ropinirole HCl
T259291374-20-8
Ropinirole hydrochloride (SKF-101468A) is a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole hydrochloride (SKF-101468A) is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with antiparkinsonian property.
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Atenolol
Tenormin, Normiten, Blokium, (RS)-Atenolol
T000729122-68-7
Atenolol (Tenormin) is a selective β1 receptor antagonist.
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β-Nicotinamide mononucleotide
β-NM, NMN
T47211094-61-7
β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
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Cilomilast
SB-207499, Ariflo
T6445153259-65-5
Cilomilast (SB-207499) is a potent PDE4 inhibitor with an IC50 of approximately 110 nM, demonstrating anti-inflammatory activity and minimal central nervous system effects. Phase 3.
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Perospirone
Lullan
T4576150915-41-6
Perospirone (Lullan) is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
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Bisindolylmaleimide IV
T7659119139-23-0
Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)
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pd-161570
PD 161570
T23127192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. It also inhibits the PDGFR, EGFR, and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
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t.cruzi-in-1
T.cruzi Inhibitor, MDK1088
T41981350920-22-7
T.cruzi-IN-1 (MDK1088) is a Trypanosoma cruzi inhibitor.
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7-10 days
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bl-918
T83222101517-69-3
BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.
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Sevelamer Carbonate
T6666845273-93-0
Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
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7-10 days
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KDM4-IN-4
T603542230475-63-3In house
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It inhibits H3K4Me3 binding to the Tudor domain in cellular contexts with an EC50 value of 105 μM, holding potential for anticancer research applications [1].
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8-10 weeks
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SEW​2871
SEW2871
T2171256414-75-2
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.
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Elamipretide
SS-31, RX-31, MTP-131
TP1095736992-21-5
Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier permeability. It is a potential therapeutic agent in the rare disease of Barnes syndrome.
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Tocilizumab
T9911375823-41-9
Tocilizumab (Anti-Human IL6R) is a neutralizing antibody against human interleukin-6 receptor (IL-6R) that blocks the binding of IL-6 to IL-6R, thereby inhibiting both classical and trans signaling. It can be used to study rheumatoid arthritis and has been suggested as a possible drug for the treatment of severe COVID-19.
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Tezepelumab
Tezepelumab-ekko, MEDI 19929, AMG 157
T773591572943-04-4
Tezepelumab (AMG 157) is a humanized monoclonal antibody (IgG2λ) targeting TSLP that prevents TSLP from interacting with its heterodimer receptor. Tezepelumab can be used to study advanced asthma disease.
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Mitiperstat
AZD4831
T610281933460-19-5
Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease.
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8-10 weeks
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