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disease

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  • Inhibitors & Agonists
    2443
    TargetMol | Inhibitors_Agonists
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    TargetMol | Compound_Libraries
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    TargetMol | Inhibitors_Agonists
Finerenone
BAY94-8862, BAY-94-8862, BAY-948862, BAY948862, BAY 94-8862, BAY 948862
T213951050477-31-0
Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes.
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MPTP hydrochloride
MPTP-hydrochloride
T408123007-85-4
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.
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Selisistat
SEN0014196, EX-527
T611149843-98-3
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50 = 38 nM) and can be utilized in the study of neurological disorders such as Huntington's chorea.
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voxelotor
GBT 440
T75811446321-46-5
Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).
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gsk2292767
T68501254036-66-2In house
GSK2292767 is a potent and selective inhibitor of PI3Kδ.
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Atenolol
Tenormin, Normiten, Blokium, (RS)-Atenolol
T000729122-68-7
Atenolol (Tenormin) is a selective β1 receptor antagonist.
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Imiquimod
S-26308, R 837, IMQ
T013499011-02-6
Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.
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Inosine
NSC 20262, INO 495
T043758-63-9
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
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Carbidopa monohydrate
S(-)-Carbidopa, Carbidopa Hydrate
T214838821-49-7
Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
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Ropinirole hydrochloride
SKF-101468A, SKF 101468 hydrochloride, Ropinirole HCl
T259291374-20-8
Ropinirole hydrochloride (SKF-101468A) is a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole hydrochloride (SKF-101468A) is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with antiparkinsonian property.
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Nootkatone
T3S01954674-50-4
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.
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Norharmane
β-Carboline, 2-Azacarbazole, 2,9-Diazafluorene
T4024244-63-3
Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
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β-Nicotinamide mononucleotide
β-NM, NMN
T47211094-61-7
β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
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Heptadecanoic acid
T4903506-12-7
Heptadecanoic acid is a fatty acid of exogenous (primarily ruminant) origin. Many odd length long chain amino acids are derived from the consumption of dairy fats (milk and meat). Heptadecanoic acid constitutes 0.61% of milk fat and 0.83% of ruminant me
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Methyl tridecanoate
TN69191731-88-0
Methyl tridecanoate is a natural product.
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Perospirone
Lullan
T4576150915-41-6
Perospirone (Lullan) is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
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Cinacalcet metabolite M4
Rarechem AL BW 1078
T10814104774-87-0
Cinacalcet metabolite M4 (Rarechem AL BW 1078) is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor.
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pd-161570
PD 161570
T23127192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. It also inhibits the PDGFR, EGFR, and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
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Etilevodopa hydrochloride
Levodopa ethyl ester, Etilevodopa HCl,  L-DOPA ethyl ester
T2404739740-30-2
Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
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(-)-Huperzine A
Huperzine A, HupA
T3026102518-79-6
(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
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Betahistine
Vasomotal, Serc base, PT 9 base
T41955638-76-6
Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahistine dihydrochloride is an anti-vertigo drug. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.
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t.cruzi-in-1
T.cruzi Inhibitor, MDK1088
T41981350920-22-7
T.cruzi-IN-1 (MDK1088) is a Trypanosoma cruzi inhibitor.
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7-10 days
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Cilomilast
SB-207499, Ariflo
T6445153259-65-5
Cilomilast (SB-207499) is a potent PDE4 inhibitor with an IC50 of approximately 110 nM, demonstrating anti-inflammatory activity and minimal central nervous system effects. Phase 3.
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Sevelamer Carbonate
T6666845273-93-0
Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.
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7-10 days
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