d 13

D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. |1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).

The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.

Colfosceril miristate-d13 (DMPC-d13) is the deuterated form of Colfosceril miristate. Colfosceril miristate (DMPC) is a synthetic phospholipid utilized in the study of liposomes and lipid bilayers. It is employed for research on lipid monolayers and bilayers.

Choline-d13 Bromide (N,N,N-trimethyl-d9; 1,1,2,2-d4) is a deuterated compound of Choline Bromide. Choline Bromide has a CAS number of 1927-06-6.

Mycophenolic acid-13C-d3 the 13C and deuterated compound of Mycophenolic acid. Mycophenolic acid has a CAS number of 24280-93-1. Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.

Lusutrombopag-d13 is a deuterated compound of Lusutrombopag. Lusutrombopag has a CAS number of 1110766-97-6. Lusutrombopag is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.

Homovanillic Acid-13C-d3 the 13C and deuterated compound of Homovanillic Acid. Homovanillic Acid has a CAS number of 306-08-1. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Levomefolic Acid-13C-d3 the 13C and deuterated compound of Levomefolic Acid. Levomefolic Acid has a CAS number of 31690-09-2. Levomefolinic acid is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency

Alachlo-d13 (2,6-diethylphenyl-d13) is a deuterated compound of Alachlo.

β-Apo-13-carotenone D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone is an antagonist of RXRα.

11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester is a natural product for research related to life sciences. The catalog number is TN6271 and the CAS number is 75911-16-9.

Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a cyclic peptide that functions as a melanocyte-stimulating hormone. It significantly prolongs melanocyte activity in the skin of frogs and lizards and acts as a potent agonist. Additionally, Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) demonstrates complete resistance to trypsin degradation.

13-cis Retinoyl β-D-glucuronide is a biochemical reagent employed in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It encompasses carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the roles of glycans in biological systems, closely linking to basic research, biomedicine, and biotechnology.

Apixaban 13C,d3 is a deuterium labeling of Apixaban for isotopic tracing. Apixaban 13C,d3 is a selective inhibitor of coagulation factor Xa and is used in thromboembolism studies

PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor.

13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid.

D-Glucose-13C6 (Dextrose-13C6) is an isotopic marker of D-Glucose, which can be used as a metabolic tracer for the study of metabolism-related diseases and metabolic processes of some substances in the body.

Tiopronin 13C D3 is deuterium labeled Tiopronin.

D-(+)-Trehalose-13C12 is an isotopic label of D-(+)-Trehalose, enriched with 13C. This compound is pervasively found and often employed as a food ingredient and a shape-forming agent for active molecules.

KRAS G13D-IN-1 (compound 41) is a selective and covalent reversible inhibitor of KRASG13D with an IC50 value of 0.41 nM, exhibiting 29-fold selectivity over wild-type KRAS. It acts as a GDP-state inhibitor and targets the SWII binding pocket of KRASG13D. KRAS G13D-IN-1 inhibits GDP binding to KRAS and modulates downstream signaling cascades.

D-Fructose-13C6 can be used as an internal standard for the quantification of D-fructose by GC- or LC-MS.

2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.4,5In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin or paclitaxel .6 1.Kang, H.T., and Hwang, E.S.2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimeticLife Sci.78(12)1392-1399(2006) 2.Aft, R.L., Zhang, F.W., and Gius, D.Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell deathBr. J. Cancer87(7)805-812(2002) 3.Ralser, M., Wamelink, M.M., Struys, E.A., et al.A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growthProc. Natl. Acad. Sci. USA105(46)17807-17811(2008) 4.Liu, H., Savaraj, N., Priebe, W., et al.Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: A strategy for solid tumor therapy (Model C)Biochem. Pharmacol.64(12)1745-1751(2002) 5.Zhang, X.D., Deslandes, E., Villedieu, M., et al.Effect of 2-deoxy-D-glucose on various malignant cell lines in vitroAnticancer Res.26(5A)3561-3566(2006) 6.Maschek, G., Savaraj, N., Priebe, W., et al.2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivoCancer Res.64(1)31-34(2004)

13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in ordered lipid domains (lipid rafts). Sphingomyelinases remove phosphorylcholine from C16 sphingomyelin to produce C16 ceramide. While ceramides commonly induce apoptosis, ceramides with different fatty acid chain lengths might direct distinct functions and, in some cases, reduce apoptosis.

Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2. 13,14-dihydro-15-keto Prostaglandin D1 (13,14-dihydro-15-keto PGD1) is the theoretical metabolite of PGD1 via the 15-hydroxy PG dehydrogenase metabolic pathway. No biological studies for this compound have been reported.