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Results for "

cyclooxygenase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    302
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | Dye_Reagents
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    93
    TargetMol | Natural_Products
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    TargetMol | Inhibitors_Agonists
Vedaprofen
Quadrisol, PM 150, CERM 10202
T3668371109-09-6In house
Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM.
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Aspirin
ASA, Acetylsalicylic Acid, Acetylsalicylate
T000550-78-2
Aspirin (Acetylsalicylic Acid) is a COX inhibitor that inhibits COX1 and COX2 (IC50=5 210 μg mL) with selective, irreversible, and oral activity. Aspirin is also a histone deacetylase inhibitor that up-regulates the cell cycle blocking protein, p21. Aspirin has a variety of activities. Aspirin has anti-inflammatory, antipyretic and analgesic, and antiplatelet aggregation activities.
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TargetMol | Citations Cited
Acetaminophen
Paracetamol, APAP, 4'-Hydroxyacetanilide, 4-Acetamidophenol
T0065103-90-2
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7 25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.
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Valdecoxib
SC 65872
T0219181695-72-7
Valdecoxib (SC 65872) is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.
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Sodium salicylate
Salicylic acid sodium salt, 2-Hydroxybenzoic acid sodium salt
T033554-21-7
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
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Methyl salicylate
Wintergreen oil, Natural wintergreen oil, Methyl 2-hydroxybenzoate, Gaultheria oil, Betula oil, 2-Carbomethoxyphenol
T0399119-36-8
Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments.
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(S)-(+)-Ibuprofen
Dexibuprofen, (S)-Ibuprofen
T044851146-56-6
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
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7-10 days
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Indomethacin
Indomethacine, Indometacine, Indometacin, Indocin
T045853-86-1
Indomethacin (Indomethacin) is a COX1 and COX2 inhibitor (IC50=18 26 nM) with blood-brain barrier permeability and non-selectivity. Indomethacin is a non-steroidal anti-inflammatory agent with anti-tumor and anti-infective activity.
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TargetMol | Citations Cited
Celecoxib
SC 58635
T0466169590-42-5
Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.
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TargetMol | Citations Cited
Oxaprozin
Wy21743, Oxaprozinum
T070821256-18-8
Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.
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Fenbufen
Lederfen, CL-82204
T085936330-85-5
Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.
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Etodolac
Ultradol, Lodine, Etodolic acid, AY-24236
T100241340-25-4
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic acid and non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. It also inhibits platelet aggregation by blocking platelet cyclooxygenase and the subsequent formation of thromboxane A2.
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Rofecoxib
MK-0966, MK 966
T1185162011-90-7
Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2.
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Oxidopamine hydrobromide
6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide
T12352L636-00-0
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.
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TargetMol | Citations Cited
Nabumetone
BRL14777
T125842924-53-8
Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
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Guaiacol
O-methylcatechol, o-methoxyphenol, 2-Methoxyphenol, 2-hydroxyanisole
T130190-05-1
Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator in chemical reactions that produce oxygen. When oxygen binds to it, the complex turns yellowish brown and absorbs light maximally at about 470 nm.
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Phenylbutazone
Butazolidine
T143250-33-9
Phenylbutazone (Butazolidine) is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylitis, rheumatoid arthritis, and reactive arthritis.
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Lornoxicam
TS110, Ro 13-9297, Chlortenoxicam
T146870374-39-9
Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
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Diclofenac sodium
GP 45840
T155515307-79-6
Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
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Etoricoxib
Tauxib, Nucoxia, MK-663, L-791456, Desvenlafaxine, Arcoxia
T1574202409-33-4
Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
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Naproxen
(S)-Naproxen
T158222204-53-1
Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
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TargetMol | Citations Cited
Ketorolac
Toradol, Sprix, Macril, Acuvail, Acular
T2141274103-06-3
Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.
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Asaraldehyde
Asarylaldehyde, Asaronaldehyde, 2,4,5-trimethoxy-Benzaldehyde
T28264460-86-0
Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde), a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1.
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Rutaecarpine
Rutecarpine, Rutacarpine, Rhetine
T297284-26-4
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
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