convulsant

Bicuculline is an alkaloid extracted from Corydalis decumbens, acting as a competitive antagonist of the neurotransmitter GABAA receptor (IC50 = 2 μM). It also blocks Ca2+-activated potassium (SK) channels and inhibits slow afterhyperpolarization (slow AHP). Bicuculline has anticonvulsant effects and is commonly used to establish mouse seizure models.

Bicuculline methochloride is a convulsant alkaloid and a selective GABAA receptor antagonist (IC50 = 3 μM) that can block Ca²⁺-activated potassium channels. It induces clonic-tonic seizures in mammals and is commonly used to establish animal models of epilepsy.