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Results for "

cdk5-p25

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    36
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    2
    TargetMol | Peptide_Products
  • PROTAC Products
    3
    TargetMol | PROTAC
  • Recombinant Protein
    4
    TargetMol | Recombinant_Protein
pha-793887
PHA793887, PHA 793887
T2113718630-59-2
PHA-793887 has been used in trials studying the treatment of Advanced Metastatic Solid Tumors.
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lerociclib
G1T-38, G1T38, G1T 38
T113451628256-23-4
Lerociclib (G1T38) is a selective and highly potent CDK4 6 inhibitor with anticancer and antitumor activity, inhibits CDK4 CyclinD1 and CDK6 CyclinD3, and inhibits tumor growth in an animal model of endocrine-resistant breast cancer. Due to the poor solubility, for animal studies, the salt form T11345L is recommended.
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8-10 weeks
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Lerociclib dihydrochloride
G1T38 dihydrochloride
T11345L2097938-59-3
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective CDK4 CDK6 inhibitor, with IC50 values of 2 nM for CDK6 CyclinD3 and 1 nM for CDK4 CyclinD1.
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TargetMol | Inhibitor Sale
MeBIO
T21966667463-95-8
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1 CyclinB, respectively. MeBIO does not affect GSK-3β.
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TargetMol | Inhibitor Sale
Indirubin-3'-monoxime
Indirubin-3'-oxime
T5200160807-49-8
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100 180 250 nM for Cdk5 p35, Cdk1 cyclin B, Cdk2 cyclin E).
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5-Iodo-indirubin-3'-monoxime
T10172331467-03-9In house
5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5 P25, and CDK1 cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM).
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6-8 weeks
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DSS30
T61439883027-32-5In house
DSS30 is a P25 CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and treatment of neurodegenerative diseases such as Alzheimer's disease.
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6-8weeks
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NVP-LCQ195
AT9311, LCQ-195
TQ0068902156-99-4In house
NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
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Abemaciclib
LY2835219, CDK4 6 dual inhibitor
T23811231929-97-7
Abemaciclib (LY2835219) is a dual inhibitor of CDK4 6 (IC50=2 10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.
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Abemaciclib methanesulfonate
LY2835219 mesylate, LY2835219 (methanesulfonate), LY2835219, abemaciclib mesylate
T31111231930-82-7
Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
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KenPaullone
NSC-664704, 9-Bromopaullone
T2247142273-20-9
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp3 gene by enhancing TGFβ-Smad3 signaling pathway.
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(R)-CR8 trihydrochloride
CR8, (R)-Isomer trihydrochloride
T126171786438-30-9
(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1 2 5 7 9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.
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7-10 days
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(R)​-​CR8
CR8, (R)-Isomer
T12617L294646-77-8
(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.
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TargetMol | Inhibitor Sale
CGP60474
T14943164658-13-3
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.
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4-6 weeks
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NU6140
T16359444723-13-1
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
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AZD2858
T1957486424-20-8
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.
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TMX-2138
T2043432488892-07-3
TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1 cyclinB, 10.9 nM for CDK2 cyclinA, 7.0 nM for CDK5 p25, and 25.7 nM for CDK9 cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.
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Aloisine A
T21377496864-16-5
Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GSK-3α (IC50: 500nM), GSK-3β (IC50: 6
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6-8 weeks
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NSC 693868
T2309340254-90-8
CDKs and GSK-3 inhibitor
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6-8 weeks
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(r)-drf053 dihydrochloride
T232241241675-76-2
cdk CK1 inhibitor,potent and ATP-competitive
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6-8 weeks
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rp-106
RP 106
T24734496864-15-4
RP-106 is an ATP-competitive inhibitor of CDK5 p25, CDK1 cyclin B, and GSK-3.
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6-8 weeks
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AZD-5438
AZD5438
T2506602306-29-6
AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).
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TargetMol | Inhibitor Sale
LDN-193665
LDN 193665,LDN193665
T256501289638-16-9
LDN-193665 is a potent inhibitor of tau kinase. It acts by targeting CDK5/p25 and GSK3β.
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6-8 weeks
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pnu-292137
PNU 292137
T28434326823-27-2
PNU-292137 is an inhibitor of CDK2 cyclin A with the activity of antitumor.
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6-8 weeks
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