Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Caspase
    (14)
  • Apoptosis
    (12)
  • Autophagy
    (4)
  • Bcl-2 Family
    (4)
  • HDAC
    (4)
  • DNA/RNA Synthesis
    (3)
  • PARP
    (3)
  • CRISPR/Cas9
    (2)
  • LPL Receptor
    (2)
  • Others
    (11)
Filter
Search Result
Results for "

caspase-3/7

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    51
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    6
    TargetMol | Peptide_Products
  • Dye Reagents
    2
    TargetMol | Dye_Reagents
  • PROTAC Products
    1
    TargetMol | PROTAC
  • Natural Products
    7
    TargetMol | Natural_Products
  • Recombinant Protein
    8
    TargetMol | Recombinant_Protein
Caspase-3/7 Inhibitor I
T2030481110670-49-9
Caspase-3 7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Ki values of 60 and 170 nM, respectively. It effectively inhibits apoptosis in Jurkat cells and chondrocytes treated with Camptothecin.
  • Inquiry Price
Size
QTY
Caspase-3/7 activator 2
T72315
Caspase-3 7 Activator 2 is a potent compound that selectively activates Caspase-3 7, demonstrating tumor specificity, anti-proliferative properties, and a high capacity for inducing apoptosis.
  • Inquiry Price
6-8 weeks
Size
QTY
Caspase-3/7 activator 3
T72316
Caspase-3 7 Activator 3 is a potent and tumor-selective compound that effectively activates Caspase-3 7, demonstrating significant anti-proliferative activity and a high capacity to induce apoptosis.
  • Inquiry Price
6-8 weeks
Size
QTY
Dehydrocorydaline
Dehydrocorydalin, 13-Methylpalmatine
T5S235830045-16-0
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax Bcl-2, activating caspases as well as cleaving PARP.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
OUP-186
OUP186
T282751480830-24-7In house
OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell dea
  • Inquiry Price
6-8 weeks
Size
QTY
Q-VD-OPH
Quinoline-Val-Asp-Difluorophenoxymethylketone
T02821135695-98-5
Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a pan-caspase inhibitor with potent antiapoptotic properties.
  • Inquiry Price
Size
QTY
Z-DEVD-FMK
Caspase-3 Inhibitor
T6005210344-95-9
Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
  • Inquiry Price
Size
QTY
PF-543
Sphingosine Kinase 1 Inhibitor II, PF 543
T60851415562-82-1
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 of 2.0 nM and Ki of 3.6 nM.
  • Inquiry Price
Size
QTY
PF-543 hydrochloride
PF-543 HCL
T88401706522-79-3
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
CIL62
T8468117593-36-9
CIL62 is a Necrostatin-1 dependent inducer of cell death through a caspase-3 7-independent mechanism [1].
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
ALPHA-PINENE
(-)-Alpha-Pinene
TL00032437-95-8
ALPHA-PINENE ((-)-Alpha-Pinene) is a bicyclic monoterpene found in pine trees and other plants, including Cannabis with diverse biological activities [1]. It reduces the growth of a panel of seven Gram-positive bacteria, seven Gram-negative bacteria, and eight yeast strains with MIC values of 0.75-1.29, 1.05-1.59, and 0.7-1.17%, respectively [2]. It has insecticidal activity against C. molestus larvae with LC50 values ranging from 47 to 49 mg L.3 ALPHA-PINENE (100 μg ml) induces apoptosis, increases anion superoxide production and DNA fragmentation, and activates caspase-3 in B16 F10 melanoma cells [4]. In a B16 F10 mouse xenograft model, ALPHA-PINENE(100 ml of a 10 mg ml solution) reduces the number of metastatic lung nodules by approximately 7-fold. ALPHA-PINENE(8.6 mg L, aerosol) also increases the time spent in the open arms of the elevated plus maze by approximately 2-fold in mice, indicating anxiolytic-like activity [5].
  • Inquiry Price
4-6 weeks
Size
QTY
TargetMol | Inhibitor Sale
Farudodstat
ASLAN003
T103841035688-66-4
Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity, showing potential as a first-in-class candidate in AML [Acute Myeloid Leukemia].
  • Inquiry Price
Size
QTY
Frondoside A
T11325127367-76-4
possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,
  • Inquiry Price
Size
QTY
SCR7 pyrazine
T172414892-97-8
SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
Ac-DEVD-AMC
AC-ASP-MET-GLN-ASP-AMC, AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN
T18909169332-61-0
Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .
  • Inquiry Price
Size
QTY
Bfl-1-IN-5
T201041
Bfl-1-IN-5 (Compound (R,R,S)-26) is a selective inhibitor of Bfl-1, demonstrating an IC50 of 0.022 μM. This compound enhances the activity of caspase-3 7, with an EC50 of 0.37 μM, and also inhibits the viability of SU-DHL-1 cells, showing an EC50 of 1.3 μM.
  • Inquiry Price
Size
QTY
MAPK-IN-3
T2034022848599-79-9
MAPK-IN-3 (Compound 4a) is an antiproliferative agent demonstrating significant inhibitory effects on KYSE 30, HCT 116, and HGC 27 cell lines, with IC50 values of 0.57 μM, 3.27 μM, and 2.28 μM, respectively. This compound arrests the cell cycle via a p53-dependent mechanism and induces apoptosis through a p53-independent pathway. It reduces the expression of cell cycle-related proteins, such as Cyclin D1 and Cyclin B1, while increasing pro-apoptotic proteins like cleaved PARP, cleaved caspase-7, and cleaved caspase-9. MAPK-IN-3 also decreases anti-apoptotic proteins such as Bcl-2, elevates ROS levels in KYSE 30 cells, and enhances the expression of ROS-related MAPK pathway members, including p-ERK, p-p38, and p-JNK.
  • Inquiry Price
Size
QTY
CB2 receptor agonist 8
T203567
CB2 receptor agonist 8 (Compound 17) is an agonist of the cannabinoid receptor 2 (CB2 receptor). It shows cytotoxicity in U87, RPMI 8226, HL-60, and L929 cells with IC50 values of 91.03, 16.29, 23.51, and 564.6 μM, respectively. CB2 receptor agonist 8 activates caspase 3 7, increases the expression of pro-apoptotic genes BAX, BAD, BIM, and the tumor suppressor gene p53, and induces apoptosis in U87 cells. Additionally, it inhibits the migration of U87 cells.
  • Inquiry Price
Size
QTY
HDAC-IN-83
T203648
HDAC-IN-83 (compound 9D) is an inhibitor of histone deacetylase (HDAC), demonstrating an IC50 of 0.01 μM for HDAC1 and 0.44 μM for HDAC6. It exhibits anticancer and antiproliferative activities and promotes caspase-3 7 activation. The compound inhibits Cal27, HepG2, and MRC-5 cells with IC50 values of 0.693 μM, 0.427 μM, and 3.19 μM, respectively.
  • Inquiry Price
Size
QTY
Antitumor agent-196
T2050492705841-17-2
Antitumor agent-196 (Compound 6a (β, β, β)) is an artemisinin-based oligomer with anticancer properties, exhibiting an IC50 of 90 nM against MCF-7 breast cancer cells. This compound induces apoptosis by modulating the Bax-caspase 3 signaling pathway and triggers ferroptosis by regulating key signaling molecules (including GPX4). Antitumor agent-196 shows potential for cancer research applications.
  • Inquiry Price
Size
QTY
MX1013
MX 1013,MX-1013
T21293582316-00-5
MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.
  • Inquiry Price
7-10 days
Size
QTY
mmpsi
Caspase-3 7 Inhibitor I
T21871220509-74-0
MMPSI (Caspase-3 7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.MMPSI can be used to study cardioprotection and myocardial injury.
  • Inquiry Price
6-8 weeks
Size
QTY
7BIO
T22012916440-85-2
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.
  • Inquiry Price
Size
QTY
Dehydrocorydaline nitrate
T2S236213005-09-9
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially attributed to DHC. 2. Dehydrocorydal
  • Inquiry Price
7-10 days
Size
QTY