blood coagulation

Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM.

Dextran (Dextran 40) inhibits platelet aggregation and coagulation factors, can partially replace whole blood during transfusion, and is commonly used as a plasma volume expander; it can also be used in paw edema models.

Dextran sulfate sodium salt (MW 4500-5500) is a polymer of dehydrated glucose and an inhibitor of complement and coagulation pathways. Dextran sulfate sodium salt (MW 4500-5500) can be used as an anticoagulant, antiviral agent and antilipidemic agent. Dextran sulfate sodium salt (MW 4500-5500) can prevent the HIV-1 virus from adsorbing onto host cells. Dextran sulfate sodium salt (MW 4500-5500) can inhibit NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) can inhibit the immediate blood-mediated inflammatory response (IBMIR).

Vitamin K4 (Menadiol Diacetate) is a vitamin medicine for the treatment of blood coagulation disorders that caused by the lack of VK4.

DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) is a cysteine derivative that binds to and induces conformational changes in various plasma proteins, slowing coagulation and inducing oxidative stress. It decreases left ventricular systolic blood pressure and cardiac force and induces seizures in vivo.

Fibrin, the primary constituent of blood clots, is an insoluble protein essential for coagulation. Isolated from bovine blood, this protein is notably synthesized in response to bleeding.

Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.

MurineAntithrombin III is an enzyme that inhibits blood coagulation, characterized by high catalytic efficiency, high specificity, and mild operating conditions. It is applicable across various sectors, including the pharmaceutical industry, industrial production, food manufacturing, and animal husbandry.

Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage.

Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percutaneous coronary intervention (PCI)

Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to

Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation.

Darexaban maleate is a derivative used in the preparation of inhibitors of activated blood coagulation factor X.

Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg kg, Milvexian exhibited an overall exposure of 1215 nM h, low clearance of 10.3 mL min kg, and oral bioavailability of 32%.

Anpocogin, a variant of the Ancyclostoma canium nematode anticoagulant protein c2 with an added C-terminal P85, is synthesized in Pichia pastoris and functions as an anticoagulant agent [1].Recombinant nematode anticoagulant protein c2 (rNAPc2) is a potent inhibitor of serine protease factor VIIa and its cell-associated cofactor tissue factor FVIIa TF, a key physiological initiator of blood coagulation, with potential efficacy in the treatment of disseminated intravascular coagulopathy and venous and arterial thrombosis.

Omfiloctocog alfa (SCT-800), a recombinant factor VIII (FVIII), is an essential protein for blood coagulation and a critical element of the fluid phase blood coagulation system. It is utilized in the research of Hemophilia A [1] [2].

S-(1,2-Dicarboxyethyl)glutathione is a peptide recognized for its inhibitory effects on blood coagulation and platelet aggregation [1].

Ap4C tetrasodium is a dinucleotide polyphosphate that includes both purine and pyrimidine bases. This compound functions as a signaling molecule by interacting with specific P2Y receptors. It activates P2Y2 and P2Y4 receptors in platelets, inducing platelet aggregation and other cellular responses. Ap4C tetrasodium is utilized in studies related to inflammation and blood coagulation.

The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg

E-76 is a peptide with anticoagulant activity that inhibits blood coagulation by specifically binding to the exogenous coagulation factor VIIa (FVIIa). It is utilized in the study of blood coagulation-related diseases.

Fibronectin (from bovine plasma) plays pivotal roles in various cellular processes including tissue repair, embryogenesis, blood coagulation, and cell migration/adhesion.

Bemiltenase alfa is a hemostatic agent that targets coagulation factor X (FX). It activates FX to facilitate the conversion of prothrombin into thrombin, which subsequently transforms fibrinogen into fibrin, thereby forming a stable blood clot and exerting its hemostatic effect. Bemiltenase alfa shows potential for research in bleeding symptoms associated with hemophilia.

Nonacog gamma is a coagulation factor IX (FIX) supplement that activates factor X (FX), facilitating the generation of thrombin, which then converts fibrinogen into fibrin to form a stable blood clot and exert hemostatic effects. Nonacog gamma holds potential for research in the treatment of hemophilia B.