acth , human

Adrenocorticotropic Hormone (ACTH) (4-10), human is a potent agonist of the melanocortin receptor (MC4R).

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat), the fragment spanning amino acids 3-24 of adrenocorticotropic hormone (ACTH), serves as a research tool in studying illnesses such as cancer, immune diseases, and cardiovascular disease [1].

(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an adrenocorticotropic hormone (ACTH) analogue synthesized by the anterior pituitary gland to regulate cortisol and androgen production. This polypeptide tropic hormone variant differs from ACTH by the absence of glutamic acid at the fifth position.

(Des-His^6)-ACTH (1-24) (human, bovine, rat) is an adrenocorticotropic hormone (ACTH) analog. Produced by the anterior pituitary gland, ACTH is a polypeptide tropic hormone that regulates the production of cortisol and androgens [1].

Acetyl-ACTH (2-24) (human, bovine, rat), a proopiomelanocortin (POMC) peptide fragment, includes adrenocorticotrophin (ACTH) precursor of α-MSH and serves as an agonist at the MC-1 receptor [1].

Acetyl-ACTH (3-24) (human, bovine, rat), a segment derived from the proopiomelanocortin (POMC) peptide, functions as an agonist at the MC-1 receptor [1]. Encompassing adrenocorticotrophin (ACTH), a precursor to α-MSH, it illustrates its role within the spectrum of POMC peptides.

Acetyl-ACTH (4-24) (human, bovine, rat), a proopiomelanocortin (POMC) peptide fragment, functions as an agonist at the MC-1 receptor [1]. This compound encompasses a sequence present in adrenocorticotrophin (ACTH), the precursor for α-MSH, illustrating its significant role in the POMC peptide family.

Acetyl-ACTH (7-24) (human, bovine, rat) effectively inhibits corticosterone and aldosterone secretion triggered by ACTH stimulation [1].

ACTH (7-38) (human) is a fragment (7-38) of the full human adrenocorticotropic hormone (ACTH (1-39)), also known as corticotropin inhibitory peptide (CIP). It functions as an antagonist to the ACTH receptor and lacks corticosteroid activity [1].

Adrenocorticotropic hormone (6-24) (ACTH (6-24) (human)) is a fragment of ACTH that acts as a competitive inhibitor of steroidogenesis prompted by full-length ACTH (1-39) and the shortened ACTH (5-24), with dissociation constants (Kd) of 13.4 nM and 3.4 nM, respectively. It also impedes the production of corticosterone and the accumulation of cyclic AMP (cAMP) triggered by human parathyroid hormone (hPTH 1-34) [1] [2].

Adrenocorticotropic Hormone (ACTH) (18-39), also known as the Corticotropin-like Intermediate Lobe Peptide, stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to secretin and carbamylcholine.

Adrenocorticotropic Hormone (ACTH) (1-10), human, is a fragment of adrenocorticotropin hormone. It demonstrates weak α-melanocyte stimulating hormone (α-MSH) potency, which is only apparent at high doses (100 and 1000 nM).

ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).

Neuropeptide SF (human) acetate is a neuropeptide that augmented paraventricular CRH release and increased ACTH and corticosterone levels in the plasma.

Lys-γ3-MSH(human) TFA, a melanocortin peptide originating from the C-terminal fragment of pro-opiomelanocortin (POMC), enhances the steroidogenic response of rat adrenal glands to adrenocorticotrophin (ACTH). It is a potent stimulator of lipolysis, demonstrating an apparent EC50 of 3.56 nM, by activating hormone-sensitive lipase (HSL) and Perilipin A, leading to lipolysis [1] [2].

ACTH (1-17) TFA, an analogue of adrenocorticotropin, is a potent agonist for the human melanocortin 1 (MC1) receptor with a dissociation constant (K i) of 0.21 nM.

[DPro5] Corticotropin Releasing Factor, human, rat, a selective R2 agonist of corticotropin-releasing factor/hormone (CRF), is a hypothalamic hormone that prompts the release of adrenocorticotropic hormone (ACTH) and β-endorphin. Unlike typical agents, it does not induce anxiogenic effects but instead influences learning and memory processes in rats [1].

Defensin NP-3A (NP-3A; Corticostatin 1), a human granulocyte peptide, exhibits anti-ACTH activity and belongs to the defensins, a group of peptides known for their antimicrobial and cytotoxic activities [1] [2].

Adrenocorticotropic Hormone (ACTH) (1-39), human, is an agonist of the melanocortin receptor.

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

Asedebart is a humanized antibody expressed in CHO cells, targeting adrenocorticotropic hormone (ACTH). It acts by antagonizing and blocking the binding of ACTH to its receptor. Asedebart features a huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. For isotype controls, human IgG1 kappa can be referred to as a comparator. Asedebart is utilized in research focused on inflammatory diseases such as psoriasis and ulcerative colitis.

ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM.

ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland.

Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that releases ACTH from the anterior pituitary, stimulates the sympathetic nervous system and adrenal medulla, reduces hyperpolarizations, and acts as a functional antagonist of inflammatory mediators.