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Results for "

TAM Receptor

" in TargetMol Product Catalog
  • Inhibitor Products
    26
    TargetMol | Activity
  • Recombinant Protein
    6
    TargetMol | inventory
  • Inhibitory Antibodies
    2
    TargetMol | natural
Cabozantinib
T2586849217-68-1
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity.
  • $39
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TargetMol | Citations Cited
Gilteritinib
T44091254053-43-4
Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong antileukemic and antitumor effects. Gilteritinib is currently in several Phase 3 Clinicalal trials for acute myeloid leukemia.
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Cabozantinib hydrochloride
T51641817759-42-4
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
  • $37
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Endoxifen hydrochloride
T6827L1197194-41-4In house
Endoxifen hydrochloride, a principal active metabolite of Tamoxifen (TAM), exhibits heightened affinity and specificity towards the estrogen receptor and possesses aromatase inhibitory capability. It holds promise for breast cancer research.
  • $41
In Stock
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Bemcentinib
T62691037624-75-1
Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
  • $34
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TargetMol | Citations Cited
2-D08
T7379144707-18-6
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
  • $52
In Stock
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TargetMol | Citations Cited
Ningetinib
TQ00211394820-69-9
Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
  • $42
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TargetMol | Citations Cited
Ningetinib Tosylate
TQ00411394820-77-9
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
  • $42
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Emactuzumab
T767761448221-67-7
Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating factor 1 receptor (CSF1R) Emactuzumab has a high affinity for CSF-1R with a Ki value of 0.2 nM. Emactuzumab blocks CSF-1R dimerization and can be used to study cancers such as diffuse tenosynovial giant cell tumor (dt-GCT).
  • $328
In Stock
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Dubermatinib
T20051341200-45-0
Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.
  • $30
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RU-302
T168061182129-77-6
RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks the activation of Gas6-inducible AXL and suppresses lung cancer tumor growth.
  • $60
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SGI-7079
T69821239875-86-5
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.
  • $35
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XL092
T90522367004-54-2
XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.
  • $30
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LDC1267
T23111361030-48-9
LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).
  • $30
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CEP-40783
T44261437321-24-8
CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).
  • $31
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TAM-IN-2
T130742135642-56-5
TAM-IN-2 is an inhibitor of TAM.
  • $51
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Mipasetamab
T770852361055-48-1
Mipasetamab, an IgG1κ antibody, targets AXL, a tyrosine kinase receptor and TAM Receptor. It plays a crucial role in synthesizing ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC), known for its anti-tumor activity [1].
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UNC569
T213021350547-65-7
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.
  • $38
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UNC2541
T172051612782-86-1
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).
  • $42
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BMS 777607
T26991025720-94-8
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3 (IC50: 3.9/1.1/1.8/4.3 nM). BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.
  • $32
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ONO-7475
T83271646839-59-9
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
  • $57
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TargetMol | Inhibitor Sale
UNC2881
T26291493764-08-1
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
  • $30
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UNC2250
T19681493694-70-4
UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).
  • $38
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NPS-1034
T69071221713-92-3
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
  • $32
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DS-1205
T91231855860-24-0
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1].
  • $108
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RU-301
T74251110873-99-8
RU-301 is a novel pan-tam inhibitor
  • $118
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