rarα — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79772	RARα antagonist 1
	Compound 21, an orally active and selective RARα antagonist, exhibits a potent inhibition of the retinoic acid receptor α with an IC50 of 4.6 nM [1].
T1093	Adapalene	CD271	Apoptosis , Retinoid Receptor , Autophagy
	Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.		Apoptosis , Retinoid Receptor , Autophagy
T21714	BMS453	BMS 453,BMS-189453	Retinoid Receptor
	BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.		Retinoid Receptor
T22049	BMS 753		Retinoid Receptor
	BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM).		Retinoid Receptor
T22920	LE135	LE 135	Retinoid Receptor
	LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent ...		Retinoid Receptor
TQ0097	AGN 193109		Retinoid Receptor , Autophagy
	AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).		Retinoid Receptor , Autophagy
T1288	TTNPB	AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410	Apoptosis , Retinoid Receptor , Autophagy
	TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.		Apoptosis , Retinoid Receptor , Autophagy
T10261	AGN 196996		Others , Retinoid Receptor , Autophagy
	AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM).AGN 196996 has very low affinity for RARβ and RARγ, with a Ki of 1087 nM and 8523 nM, respectively.		Others , Retinoid Receptor , Autophagy
T22192	BMS 195614	BMS614	Retinoid Receptor
	BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.		Retinoid Receptor
T7586	Trifarotene	CD5789	Retinoid Receptor , Autophagy
	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).		Retinoid Receptor , Autophagy
T1051	Retinoic acid	Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin	Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy
	Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat...
T3955	AR7		Retinoid Receptor
	AR7 is a retinoic acid receptor α (RARα) antagonist.		Retinoid Receptor
T5854	AM580	NSC608001,CD336,Ro 40-6055	Retinoid Receptor , Autophagy
	AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )		Retinoid Receptor , Autophagy
T22767	ER 50891		Retinoid Receptor
	ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.		Retinoid Receptor
T61588	AGN 192870		Apoptosis , Retinoid Receptor
	AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.		Apoptosis , Retinoid Receptor
T10265	AGN 194078		Others
	AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).		Others
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T14144	AGN-195183		Others
	AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ. IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.) Target: RARα agonist Compoun...		Others
T14143	AGN 194310	VTP-194310	Retinoid Receptor
	AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].		Retinoid Receptor
T28589	Ro 41-5253	Ro-41-5253,Ro 415253	Apoptosis , Retinoid Receptor
	Ro 41-5253 is an orally active RARα antagonist, ligand and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation and induces apoptosis in MCF-7 and...		Apoptosis , Retinoid Receptor