rar/rxr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23383	SR11237	SR 11237	Others , RAR/RXR
	SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.		Others , RAR/RXR
T7586	Trifarotene	CD5789	Retinoid Receptor , Autophagy
	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).		Retinoid Receptor , Autophagy
T1093	Adapalene	CD271	Apoptosis , Retinoid Receptor , Autophagy
	Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.		Apoptosis , Retinoid Receptor , Autophagy
T22843	HX 531		Retinoid Receptor
	RXR antagonist		Retinoid Receptor
T15811	LY2955303		Others , Retinoid Receptor
	LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).		Others , Retinoid Receptor
T17209	UVI 3003		Retinoid Receptor , Autophagy
	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively).		Retinoid Receptor , Autophagy
TQ0097	AGN 193109		Retinoid Receptor , Autophagy
	AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).		Retinoid Receptor , Autophagy
T3955	AR7		Retinoid Receptor
	AR7 is a retinoic acid receptor α (RARα) antagonist.		Retinoid Receptor
T5341	WYC-209	WYC209	Apoptosis , Retinoid Receptor , Autophagy
	WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).		Apoptosis , Retinoid Receptor , Autophagy
T7370	Talarozole	R115866	Others , P450 , Retinoid Receptor , Autophagy
	Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of...		Others , P450 , Retinoid Receptor , Autophagy
TQ0064	Peretinoin	NIK333	HCV Protease , Retinoid Receptor , S1P Receptor , Autophagy
	Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.		HCV Protease , Retinoid Receptor , S1P Receptor , Autophagy
T6696	Tazarotene	Tazorac,AGN 190168,Zorac	Retinoid Receptor , Autophagy
	Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati...		Retinoid Receptor , Autophagy
T6410	Bexarotene	Ro 26-4455,Targretin,LGD1069	Retinoid Receptor , Autophagy
	Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).		Retinoid Receptor , Autophagy
T4538	Palovarotene	Ro 3300074,R 667	Retinoid Receptor , Autophagy
	Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).		Retinoid Receptor , Autophagy
T1872	Fenretinide	4-HPR,MK-4016,4-hydroxy(phenyl)retinamide	Retinoid Receptor , Autophagy
	Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.		Retinoid Receptor , Autophagy
T11844	LG-100064		Retinoid Receptor , Autophagy
	LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)		Retinoid Receptor , Autophagy
T5843	Tarenflurbil	MPC7869,(R)-Flurbiprofen,R-flurbiprofen	Retinoid Receptor , Autophagy
	Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.		Retinoid Receptor , Autophagy
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T6694	Tamibarotene	NSC 608000,Am 80,Amnolake	Apoptosis , Retinoid Receptor , Autophagy
	Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity.		Apoptosis , Retinoid Receptor , Autophagy
T21714	BMS453	BMS 453,BMS-189453	Retinoid Receptor
	BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.		Retinoid Receptor
T11847L	Liarozole	R75251 dihydrochloride	P450 , Retinoid Receptor
	Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...		P450 , Retinoid Receptor
T5854	AM580	NSC608001,CD336,Ro 40-6055	Retinoid Receptor , Autophagy
	AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )		Retinoid Receptor , Autophagy
T4371	CD437	AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI	Retinoid Receptor , Autophagy
	CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.		Retinoid Receptor , Autophagy
T0499	Oxybenzone	KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567	Apoptosis , Retinoid Receptor , Autophagy
	Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.		Apoptosis , Retinoid Receptor , Autophagy
T1288	TTNPB	AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410	Apoptosis , Retinoid Receptor , Autophagy
	TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.		Apoptosis , Retinoid Receptor , Autophagy
T32107	HX-603	HX 603
	HX-603 is a selectivity agonist of RXR that inhibits the activation of RAR-RXR heterodimers as well as RXR homodimers.
T70976	AGN-190121
	AGN-190121 is a retinoic acid receptor (RAR) agonist. RAR and Retinoid X Receptor (RXR) ligands can act synergistically to induce hypertriglyceridemia through distinct mechanisms of action.
T14145	AGN194204	IRX4204,NRX194204,VTP 194204	Others
	AGN194204 (IRX4204) is inactive against RAR and is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194...		Others
T10262	AGN 205327		Others
	AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively without inhibition of RXR. IC50 value: 3766/734/32 nM for RARα/β/γ Target: RAR agonist		Others

Compounds

SR11237

T23383

Synonym: SR 11237

Target: Others, RAR/RXR

trifarotene

T7586

Synonym: CD5789

Target: Retinoid Receptor, Autophagy

Adapalene

T1093

Synonym: CD271

Target: Apoptosis, Retinoid Receptor, Autophagy

HX 531

T22843

Synonym:

Target: Retinoid Receptor

LY2955303

T15811

Synonym:

Target: Others, Retinoid Receptor

UVI 3003

T17209

Synonym:

Target: Retinoid Receptor, Autophagy

AGN 193109

TQ0097

Synonym:

Target: Retinoid Receptor, Autophagy

AR7

T3955

Synonym:

Target: Retinoid Receptor

WYC-209

T5341

Synonym: WYC209

Target: Apoptosis, Retinoid Receptor, Autophagy

Talarozole

T7370

Synonym: R115866

Target: Others, P450, Retinoid Receptor, Autophagy

Peretinoin

TQ0064

Synonym: NIK333

Target: HCV Protease, Retinoid Receptor, S1P Receptor, Autophagy

Tazarotene

T6696

Synonym: Tazorac,AGN 190168,Zorac

Target: Retinoid Receptor, Autophagy

Bexarotene

T6410

Synonym: Ro 26-4455,Targretin,LGD1069

Target: Retinoid Receptor, Autophagy

palovarotene

T4538

Synonym: Ro 3300074,R 667

Target: Retinoid Receptor, Autophagy

Fenretinide

T1872

Synonym: 4-HPR,MK-4016,4-hydroxy(phenyl)retinamide

Target: Retinoid Receptor, Autophagy

LG-100064

T11844

Synonym:

Target: Retinoid Receptor, Autophagy

Tarenflurbil

T5843

Synonym: MPC7869,(R)-Flurbiprofen,R-flurbiprofen

Target: Retinoid Receptor, Autophagy

Amsilarotene

T21314

Synonym: TAC-101,TAC 101,TAC101

Target: CDK

Tamibarotene

T6694

Synonym: NSC 608000,Am 80,Amnolake

Target: Apoptosis, Retinoid Receptor, Autophagy

BMS453

T21714

Synonym: BMS 453,BMS-189453

Target: Retinoid Receptor

Liarozole

T11847L

Synonym: R75251 dihydrochloride

Target: P450, Retinoid Receptor

AM580

T5854

Synonym: NSC608001,CD336,Ro 40-6055

Target: Retinoid Receptor, Autophagy

CD437

T4371

Synonym: AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI

Target: Retinoid Receptor, Autophagy

Oxybenzone

T0499

Synonym: KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567

Target: Apoptosis, Retinoid Receptor, Autophagy

TTNPB

T1288

Synonym: AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410

Target: Apoptosis, Retinoid Receptor, Autophagy

Synonym: IRX4204,NRX194204,VTP 194204

Cat No.	Product Name	Synonyms	Targets
TN6735	Bigelovin		Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR
	Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
T1330	Acitretin	Ro 10-1670,Etretin	Apoptosis , Retinoid Receptor , Autophagy
	Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.		Apoptosis , Retinoid Receptor , Autophagy
T1611	Isotretinoin	13-cis-Retinoic acid	Retinoid Receptor , Endogenous Metabolite , Autophagy
	Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall...		Retinoid Receptor , Endogenous Metabolite , Autophagy
T1051	Retinoic acid	Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin	Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy
	Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat...
T3000	Magnolol	NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol	NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy
	Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.