ipf — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9592	OATD-01		Others
	OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).		Others
T9688	CC-90001		JNK
	CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.		JNK
T4016	BMS-986020	AM152,BMS986020	LPA Receptor , LPL Receptor
	BMS-986020 (AM152) is a selective antagonist of LPA1.		LPA Receptor , LPL Receptor
T36605	(±)5-iPF2α-VI	(±)5-iPF2α-VI
	Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can...
T19378	Ipfencarbazone		Akt
	Ipfencarbazone herbicide agent, is a substance being developed for the control of weeds such as watergrass in rice.		Akt
T68426	Dipfluzine
	Dipfluzine is a diphenylpiperazine calcium channel blocker with poor solubility.
T75004	TGFβ1-IN-2		Others
	TGFβ1-IN-2, a derivative of diarylacylhydrazones, effectively inhibits fibroblast activation and proliferation and holds potential for idiopathic pulmonary fibrosis (IPF) research [1].		Others
T75005	TGFβ1-IN-3		Others
	TGFβ1-IN-3 is a diarylhydrazone derivative with inhibitory effects on fibroblast activation and proliferation.TGFβ1-IN-3 is a candidate compound for the treatment of idiopathic pulmonary fibrosis (IPF).		Others
T76856	Andecaliximab	GS-5745	MMP , Virus Protease
	Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used ...		MMP , Virus Protease
T73035	STAT3-IN-15
	STAT3-IN-15, a potent and orally active inhibitor targeting STAT3, effectively combats idiopathic pulmonary fibrosis (IPF) by hindering STAT3 phosphorylation. Additionally, it impedes TGF-β1-induced migration and deforma...
T63486	DPPY
	DPPY is a potent inhibitor of PTK that acts on EGFR (IC50<10 nM), BTK (IC50<10 nM), and JAK3 (IC50<10 nM). DPPY inhibits the proliferation of B-cell lymphoma cells and has potential for investigation in idiopathic pulmon...
T69517	Bexotegrast HCl
	Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activati...
T72380	PI3K/mTOR Inhibitor-13
	PI3K/mTOR Inhibitor-13, an orally active dual inhibitor targeting phosphoinositol 3-kinase (PI3K) and mTOR kinase, holds potential for treating sexual diseases, solid tumors, and idiopathic pulmonary fibrosis (IPF).
T76804	FG-3019
	Pamrevlumab (FG-3019) is a recombinant human antibody targeting connective tissue growth factor (CTGF), with potential applications in idiopathic pulmonary fibrosis (IPF) research [1] [2].
T74402	FAP-PI3KI1
	FAP-PI3KI1, a fibroblast-activated protein (FAP)-targeted PI3K inhibitor, selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells. It effectively inhibits collagen synthesis and reduces collage...
T63776	PDE1-IN-4
	PDE1-IN-4 is a potent and selective inhibitor of PDE1 (phosphodiesterase-1), acting on PDE1C (IC50: 10 nM), PDE1A (IC50: 145 nM) and PDE1B (IC50: 354 nM). PDE1-IN-4 regulates cAMP (3′,5′-cyclic adenosine monophosphate) a...
T63439	BMS-986020 sodium
	BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist that inhibits bile acids and phospholipid transport proteins, and inhibits BSEP (IC50: 4.8 μM), MRP4 (IC50: 6.2 μM) and MDR3 (IC50: ...
T39933	Bexotegrast	PLN-74809	Integrin
	Bexotegrast (PLN-74809) is an orally active and potent inhibitor of αvβ6 and αvβ1 integrins with antifibrotic effects, inhibits αvβ6 and αvβ1-induced activation of TGF-β, and can be used for the study of idiopathic pulmo...		Integrin
T11935	Macitentan (n-butyl analogue)		Others
	Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibros...		Others
T64008	Thi-DPPY
	Thi-DPPY is a potent, orally active JAK3 inhibitor that acts on BTK (IC50: 62.4 nM), JAK (IC50: 1.38 nM). Thi-DPPY is anti-proliferative against HBE cells. Thi-DPPY has anti-inflammatory effects in vivo. Thi-DPPY has sho...
T74632	TP0556351		MMP
	TP0556351, a potent and selective inhibitor of matrix metalloproteinase-2 (MMP2), exhibits significant efficacy with an IC50 of 0.2 nM and demonstrates the capability to decrease collagen accumulation in a Bleomycin-indu...		MMP
T77031	Ifabotuzumab
	Ifabotuzumab (KB004), an IgG1κ antibody, specifically binds to EphA3 (K D =610 pM), inducing tumor cell apoptosis, activating antibody-dependent cell-mediated cytotoxicity (ADCC), and damaging tumor vasculature. Addition...
T63584	ATX inhibitor 12
	ATX inhibitor 12 is an orally active ATX inhibitor (IC50: 1.72 nM). In C57Bl/6J mice, oral administration of ATX inhibitor 12 at a dose of 60 mg/kg was effective in inhibiting structural lung damage and reducing fibrotic...

Compounds

OATD-01

T9592

Synonym: AM152,BMS986020

Target: LPA Receptor, LPL Receptor

(±)5-iPF2α-VI

T36605

Synonym: (±)5-iPF2α-VI

Target: MMP, Virus Protease

PI3K/mTOR Inhibitor-13

Macitentan (n-butyl analogue)

Cat No.	Product Name	Species	Expression System
TMPY-04079	LIPF Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	LIPF Protein, Human, Recombinant (His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 44.6 kDa. Accession number: AAI12273.1
TMPY-00371	STC1 Protein, Human, Recombinant (His)	Human	HEK293
	Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has...

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Targets

Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T3795	Corilagin		Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy
	Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B...