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Search Results for " cbp/p300 "

20

Compounds

Cat No. Product Name Synonyms Targets
T12345 CBP/p300-IN-3 P300/CBP-IN-3 Histone Acetyltransferase
CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.
T39826 CBP/p300-IN-8 CBP/p300-IN-8
CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains . CBP/p300-IN-8 inhibits CBP ( IC 50 =0.01-0.1 μΜ) and BRD4 ( IC 50 =1-1000 μΜ) activity.
T40344 CBP/p300-IN-14 CBP/p300-IN-14
CBP/p300-IN-14, efficiently inhibits CBP/EP300 (lysine acetyltransferase) with an IC50 value of 3.3 nM.
T40144 CBP/p300 ligand 2
CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP.
T40143 PROTAC CBP/P300 Degrader-1 PROTAC CBP/P300 Degrader-1
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T40142 Thalidomide-NH-CBP/p300 ligand 2 Thalidomide-NH-CBP/p300 ligand 2
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).
T12346 CBP/p300-IN-5 P300/CBP-IN-5 Epigenetic Reader Domain
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
T10702 CBP/p300-IN-2 CBP/EP300-IN-2 Epigenetic Reader Domain , c-Myc
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).
T9370 DCBP-1 Epigenetic Reader Domain , Ligand for E3 Ligase
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.
T8778 TTK21 Epigenetic Reader Domain
TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
T63122 CBP/p300-IN-19
CBP/p300-IN-19 is a potent inhibitor of p300/CBP HAT, which can act on P300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 1.4 μm), 2.2 μM), PCAF (IC50>100 μM), and Myst3 (IC50>100 μM). CBP/p300-IN-19 has anti-tumor activity.
T63110 CBP/p300-IN-15
CBP/p300-IN-15 (compound 13a) is a potent inhibitor of p300 (IC50: 2.5 nM) and CBP (IC50: 28.0 nM). p300-IN-15 inhibits OVCAR-3 cells (EC50: 0.865 μM) and A2780 cells (EC50. 2.71 μM). 2.71 μM). CBP/p300-IN-15 can be used...
T62720 CBP/p300-IN-18
CBP/p300-IN-18 (compound 8) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.056 μM) and LK2 H3K27 (IC50: 0.46 μM).
T62415 CBP/p300-IN-17
CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).
T79395 CBP/p300-IN-21 Epigenetic Reader Domain
CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits the growth of 4T1 tumors in mice [1].
T62700 CBP/p300-IN-16
CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM).
T72815 CBP/p300-IN-10
CBP/p300-IN-10, a potent inhibitor targeting histone acetyltransferase enzymes EP300 and CREBBP, exhibits IC50 values of 26 nM and 39 nM, respectively. This compound shows potential for anticancer research applications.
T3635 IQ 1 IQ1,IQ-1 Wnt/beta-catenin
IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on.
T63565 CBP/p300-IN-19 hydrochloride
CBP/p300-IN-19 hydrochloride is a selective and potent inhibitor of p300/CBP HAT, capable of acting on p300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 2.2 μM), PCAF (IC50>100 μM), Myst3 (IC50>100 μM). CBP/p300-IN-19 hydrochlorid...
T8658 NEO2734 EP31670 Epigenetic Reader Domain , Histone Acetyltransferase
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
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