Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).

Rupintrivir
T16809223537-30-2
Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.
  • $118
In Stock
Size
QTY
Ebselen
T082560940-34-3
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+ K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.
  • $42
In Stock
Size
QTY
TargetMol | Citations Cited
Vorinostat
T1583149647-78-9
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1 2 3 6 7 11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.
  • $44
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Dynasore
T1848304448-55-3
Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1 2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
Plerixafor
T1776110078-46-1
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
  • $42
In Stock
Size
QTY
TargetMol | Citations Cited
Brequinar
T501396187-53-0
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
  • $41
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Aspirin
T000550-78-2
Aspirin (Acetylsalicylic Acid) is a COX inhibitor that inhibits COX1 and COX2 (IC50=5 210 μg mL) with selective, irreversible, and oral activity. Aspirin is also a histone deacetylase inhibitor that up-regulates the cell cycle blocking protein, p21. Aspirin has a variety of activities. Aspirin has anti-inflammatory, antipyretic and analgesic, and antiplatelet aggregation activities.
  • $31
In Stock
Size
QTY
TargetMol | Citations Cited
Tubacin
T6327537049-40-4
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
  • $77
In Stock
Size
QTY
TargetMol | Citations Cited
LY2334737
T4061892128-60-8
LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
  • $64
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
DB772
T239661451058-50-6
DB772 is a broad-spectrum antiviral activity that inhibits Bovine Viral Diarrhea Virus (BVDV), prion activity, Border Disease Virus (BDV), HoBi Virus, Forked Horn Virus and Bungowannah Virus.
  • $117
In Stock
Size
QTY
Plerixafor octahydrochloride
T1776L155148-31-5
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. Plerixafor is a bicyclam with hematopoietic stem cell-mobilizing activity.
  • $42
In Stock
Size
QTY
TargetMol | Citations Cited
4-Phenylbutyric acid
T58861821-12-1
4-Phenylbutyric acid (Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. 4-Phenylbutyric acid can be used to treat urea cycle disorders.
  • $41
In Stock
Size
QTY
TargetMol | Citations Cited
LHF-535
T11138L1450929-77-7
LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
  • $39
In Stock
Size
QTY
AZ960
T6309905586-69-8
AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
  • $67
In Stock
Size
QTY
TargetMol | Citations Cited
Tin-protoporphyrin IX dichloride
T1316114325-05-4
Tin-protoporphyrin IX dichloride (SnPPIX dichloride) is an HO-1) inhibitor with antiviral activity that inhibits dengue and yellow fever viruses.
  • $45
In Stock
Size
QTY
A2ti-1
T36432570390-00-0
A2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK). A2ti-1 can be used to study human papillomavirus type 16 (HPV16) infection.
  • $90
In Stock
Size
QTY
(+)-JNJ-A07
T640922135640-93-4In house
(+)-JNJ-A07 is a pan-serotypic dengue virus inhibitor that targets NS3-NS4B interaction with high potency. (+)-JNJ-A07 has antiviral activity and can be used to study dengue virus infections.
  • $165 TargetMol
In Stock
Size
QTY
DENV-IN-5
T631432375781-06-7In house
Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
  • $470
In Stock
Size
QTY
NGI-1
T7366790702-57-7
NGI-1 (ML414) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) that can effectively reduce virus infectivity without affecting cell viability.
  • $36
In Stock
Size
QTY
EIDD-1931
T84983258-02-4
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity that inhibits the replication of severe acute respiratory syndrome coronavirus [SARS-CoV] in Vero 76 cells, Middle East respiratory syndrome coronavirus [MERS-CoV] in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s = 0.1, 0.15, and 0.3 μM, respectively).
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
A2ti-2
T36433482646-13-9
A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2 S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.
  • $98
In Stock
Size
QTY
Phenytoin sodium
T0008630-93-3
Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .
  • $45
In Stock
Size
QTY
Schizandrin A
T292661281-38-7
Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM.
  • $36
In Stock
Size
QTY
TargetMol | Citations Cited
PD 169316
T2432152121-53-4
PD 169316 is a potent, cell-permeable, and selective inhibitor of p38 MAP kinase.
  • $48
In Stock
Size
QTY
TargetMol | Citations Cited
Retro-2 cycl
T127111429192-00-6
Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 160 μM, respectively),with antiviral agent.
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Fluticasone (propionate)
T018880474-14-2
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist.
  • $43
In Stock
Size
QTY
TargetMol | Inhibitor Sale
116-9e
T25770831217-43-7
116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibiting simian virus 40 (SV40) replication, tumour antigen (TAg) endogenous ATPase activity, and TAg-mediated activation of Hsp70. 116-9e can be used to study cancer drug resistance.
  • $113
In Stock
Size
QTY
ESI-09
T2244263707-16-0
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
  • $35
In Stock
Size
QTY
TargetMol | Citations Cited
Carmofur
T130761422-45-5
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Pleconaril
T4536153168-05-9
Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Phenytoin
T093957-41-0
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. It potentially acts by promoting sodium efflux from neurons in the motor cortex, reducing post-tetanic potentiation at synapses. This prevents cortical seizure foci from spreading to adjacent areas and stabilizes the threshold against hyperexcitability. Additionally, it appears to reduce muscle spindle sensitivity to stretch, causing muscle relaxation.
  • $50
In Stock
Size
QTY
SRPIN340
T1954218156-96-8
SRPIN340 (SRPK inhibitor), a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).
  • $39
In Stock
Size
QTY
TargetMol | Inhibitor Sale
NH125
T6605278603-08-0
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
  • $34
In Stock
Size
QTY
ML188
T83711417700-13-0
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
  • $50
In Stock
Size
QTY
TargetMol | Inhibitor Sale
STING agonist-1
T8328702662-50-8
STING agonist-1 (G10) is a human-specific agent that elicits antiviral activity against emerging Alphaviruses.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
LabMol-319
T72051381188-63-2In house
LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.
  • $84
In Stock
Size
QTY
Pirodavir
T1750124436-59-5
Pirodavir (R77975) (R 77975), the prototype of broad-spectrum anti-picornavirus compounds, is a potent human rhinovirus (HRV) capsid-binding inhibitor.
  • $61
In Stock
Size
QTY
TargetMol | Inhibitor Sale
FGI-106 tetrahydrochloride
T11281L1149348-10-6
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.
  • $79
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Foscarnet sodium
T022063585-09-1
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
  • $40
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Retro-2
T89031201652-50-7
Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.
  • $38
In Stock
Size
QTY
TargetMol | Inhibitor Sale
PIK-93
T2616593960-11-3
PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3Kα with an IC50 of 39 nM.
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ZINC03129319
T133971777807-64-3In house
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.
  • $30
In Stock
Size
QTY
Golgicide A
T65161139889-93-2
Golgicide A is a potent and rapidly reversible GBF1 inhibitor.
  • $36
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Aminothiazole
T049596-50-4
Aminothiazole (2-Aminothiazole), a thyroid inhibitor, displays antibacterial activity.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Flaviviruses-IN-2
T720411009762-84-8In house
Flaviviruses-IN-2 is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces West Nile virus (WNV) protease activity and inhibits WNV by 56%.
  • $350
In Stock
Size
QTY
LASV inhibitor 3.3
T9957554438-52-7
LASV inhibitor 3.3 is an inhibitor of Lassa fever virus (LASV) targeting lysosome-associated membrane protein 1 (LAMP1), a host factor that binds to the LASV glycoprotein (GP) during infection.
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Sale
N-Desmethylclozapine
T51586104-71-8
N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ST-193
T13006489416-12-8
ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).
  • $48
In Stock
Size
QTY
TargetMol | Inhibitor Sale