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TargetMol | Tags Tyrosine Kinase/Adaptors

Tie-2

Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor.

FilterSignaling PathwaysTyrosine Kinase/AdaptorsTie-2
  • TIE-2/VEGFR-2 kinase-IN-5
    T798601014407-83-0In house
    TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis.
    • $195
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    TargetMol | Inhibitor Sale
  • Foretinib
    T3113849217-64-7
    Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.
    • $33
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    TargetMol | Citations Cited
  • BAY-826
    T389301448316-08-2
    BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.
    • $69
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  • EOC317
    T4318939805-30-8
    EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6 2 4 nM, for FGFR1 VEGFR2 Tie-2).
    • $93
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  • Tie2 kinase inhibitor 1
    T6335948557-43-5
    Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 μM, which is 200-fold more effective than p38.
    • $62
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  • CE-245677
    T14921717899-97-3
    CE-245677 is a potent reversible inhibitor of Tie2 and TrkA B kinases. With a cellular IC50s of 4.7 and 1 nM.
    • $56
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    TargetMol | Inhibitor Sale
  • Pexmetinib
    T6934945614-12-0
    Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK Tie-2 inhibitor with IC50 of 4 nM 18 nM in a HEK-293 cell line. Phase 1.
    • $54
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  • GSK-1070916
    T6129942918-07-2
    GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B C with IC50 of 3.5 nM 6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.
    • $41
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  • Altiratinib
    T20541345847-93-9
    Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro.
    • $48
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